AutismKB 2.0

Annotation Detail for PSMD6


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Basic Information Top
Gene Symbol:PSMD6 ( KIAA0107,Rpn7,S10,SGA-113M,p44S10 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
Band: 3p14.1
Quick LinksEntrez ID:9861; OMIM: NA; Uniprot ID:PSMD6_HUMAN; ENSEMBL ID: ENSG00000163636; HGNC ID: 9564
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03050Proteasome
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Apoptosis
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
HIV Infection
Cell Cycle Checkpoints
Regulation of activated PAK-2p34 by proteasome mediated degradation
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500401Autodegradation of Cdh1 by Cdh1:APC/C
500372SCF(Skp2)-mediated degradation of p27/p21
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PSMD6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PSMD6 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of PSMD6 mRNAdecreases expression 16514628
D002104 Cadmium Cadmium results in increased expression of PSMD6 mRNAincreases expression 17327699
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of PSMD6 mRNAincreases expression 17327699
D004958 Estradiol Estradiol results in increased expression of PSMD6 mRNAincreases expression 16514628
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PSMD6 mRNAaffects expression 17555576
C070081 fulvestrant fulvestrant results in decreased expression of PSMD6 mRNAdecreases expression 16514628
D015741 Metribolone Metribolone results in increased expression of PSMD6 mRNAincreases expression 17010196
D009151 Mustard Gas Mustard Gas results in increased expression of PSMD6 mRNAincreases expression 12884408
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of PSMD6 mRNAincreases expression 17616710
D010615 Phenacetin Phenacetin results in increased expression of PSMD6 mRNAincreases expression 17082564
C030299 phenylhydrazine phenylhydrazine results in increased expression of PSMD6 mRNAincreases expression 17082564
C031280 pyrazole pyrazole results in increased expression of PSMD6 mRNAincreases expression 17945193
D020849 Raloxifene Raloxifene results in decreased expression of PSMD6 mRNAdecreases expression 16514628
D012643 Selenium Selenium results in increased expression of PSMD6 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Estradiol 4.2211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2214692618
MESH:D000419 Albuminuria Raloxifene 4.6017308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000740 Anemia Phenacetin 9.902444515
MESH:D000740 Anemia phenylhydrazine 9.902444515
MESH:D000743 Anemia, Hemolytic Phenacetin 11.071949026 17082564 17698508
MESH:D000743 Anemia, Hemolytic phenylhydrazine 11.0717698508 17082564 17084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001249 Asthma Mustard Gas 2.7110378619
MESH:D050197 Atherosclerosis Cadmium 3.6415687053
MESH:D001284 Atrophy fulvestrant 4.8611514358
MESH:D001768 Blister Mustard Gas 5.1819167455
MESH:D001930 Brain Injuries Raloxifene 4.4916580743
MESH:D001943 Breast Neoplasms Estradiol 2.0612948864 17289903 17018787 18497071 16675129 17261762 14630087 19861407
MESH:D001943 Breast Neoplasms fulvestrant 2.0618984771
MESH:D001943 Breast Neoplasms Raloxifene 2.0617893378 16837676 15775269 16912660 17049068 17595753 17242785 15758505 17440819 15572757 17261762 17952589
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0117687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.5616705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5616924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.0817572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4515775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.316135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 11.3117332340
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.3118566989
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8816105132 17110522 11677210 17333356 16919318 15861022 17681005
MESH:D003072 Cognition Disorders Raloxifene 4.6315800139
MESH:D003092 Colitis Selenium 3.7917936198
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1617474826
MESH:D003928 Diabetic Nephropathies Estradiol 9.0219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.0217308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.0518551238 21346803
MESH:D056486 Drug-Induced Liver Injury pyrazole 9.0512499123
MESH:D056486 Drug-Induced Liver Injury Selenium 9.0515131321
MESH:D004487 Edema Mustard Gas 7.219260866 11428647 11402378 11428631
MESH:D004487 Edema Raloxifene 7.2115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.1512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.1515845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.7919148513
MESH:D016889 Endometrial Neoplasms Estradiol 7.7919148513 11473722 18566989
MESH:D004890 Erythema Mustard Gas 5.189357497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7815878914 15547721 15264214 16510608 15150132 16805852 15547733 16704527 15623463
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8815345470
MESH:D005234 Fatty Liver Raloxifene 7.8817473493
MESH:D006331 Heart Diseases Raloxifene 3.5411110106
MESH:D006333 Heart Failure Selenium 3.0717162251
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006973 Hypertension Raloxifene 2.8717577099 15787275
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9317937319
MESH:D007248 Infertility, Male fulvestrant 6.9311514358
MESH:D007249 Inflammation Mustard Gas 2.7916001271 11428620 9357497 17524151 8975870 9260866 11428631 11428647 11402378
MESH:D007251 Influenza, Human Selenium 4.2316624496
MESH:D007333 Insulin Resistance Estradiol 2.9716393666 16627594
MESH:D007674 Kidney Diseases Cadmium 10.3116322080 16226777 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 10.3116962696
MESH:D007674 Kidney Diseases Estradiol 10.3115618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.8916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.4116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.4116705839
MESH:D007680 Kidney Neoplasms Estradiol 12.4115610895
MESH:D007889 Leiomyoma Raloxifene 4.5016973256
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6714716833 14659978
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.157678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.542876784 6135515 2876786
MESH:D008171 Lung Diseases Mustard Gas 3.4518161513 18702808
MESH:D008175 Lung Neoplasms Mustard Gas 2.178781369 3148597
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0211807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0215318939
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008654 Mesothelioma Selenium 2.7915107826
MESH:D008708 Methemoglobinemia Phenacetin 4.961949026 3537620 16296465 4834387
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4416497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2816810080
MESH:D009232 Myxoma Raloxifene 5.5816343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.4118551238 7678174
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009421 Nervous System Malformations Estradiol 3.6611399458 16427766
MESH:D009503 Neutropenia Mustard Gas 3.9816761898 7688884
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9012819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9016049721
MESH:D010024 Osteoporosis Raloxifene 3.3917882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2317823083 15758505 15579764 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.2219401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.4015687053
MESH:D010954 Plasmacytoma Selenium 4.9215087411
MESH:D011041 Poisoning Mustard Gas 3.8015727166
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Cadmium 2.7117075824
MESH:D011471 Prostatic Neoplasms Estradiol 2.7116740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7115731164 16220300 16536755
MESH:D011537 Pruritus Ethinyl Estradiol 9.5915861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.5918058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9317266442 17620002 10334151 17894541 17720292
MESH:D011693 Purpura Raloxifene 5.5815770314
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8718551238
MESH:D012871 Skin Diseases Mustard Gas 2.7112880345 15451306 16961503
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3217575124 12958204
MESH:D020521 Stroke Raloxifene 3.8216837676
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.59978859
MESH:D013733 Testicular Diseases pyrazole 4.846499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013978 Tibial Fractures Estradiol 13.8219048282
MESH:D013978 Tibial Fractures Raloxifene 13.8219048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.0216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0216049721
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 12.0211144890
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 12.0217572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.2416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5816343187
Pathway ID Pathway Name
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:13 Metabolism of amino acids and derivatives
REACT:21257 Metabolism of RNA
KEGG:03050 Proteasome
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:11045 Signaling by Wnt
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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