AutismKB 2.0

Annotation Detail for MED24


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Basic Information Top
Gene Symbol:MED24 ( ARC100,CRSP100,CRSP4,DRIP100,KIAA0130,MGC8748,THRAP4,TRAP100,hTRAP100 )
Gene Full Name: mediator complex subunit 24
Band: 17q21.1
Quick LinksEntrez ID:9862; OMIM: 607000; Uniprot ID:MED24_HUMAN; ENSEMBL ID: ENSG00000008838; HGNC ID: 22963
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Gene Expression
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Pathway IDPathway Name
500652Generic Transcription Pathway
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MED24 mRNAincreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MED24 mRNAincreases expression 18648102
D016572 Cyclosporine Cyclosporine results in decreased expression of MED24 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of MED24 mRNAdecreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of MED24 mRNAdecreases expression 15171707
C041786 palm oil palm oil results in decreased expression of MED24 mRNAdecreases expression 18042831
D012643 Selenium Selenium results in increased expression of MED24 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MED24 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7615469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.8920435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.8917129689 15324884
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.237296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.2316924424 15948411
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.107505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.479022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.4719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15668235 15340226 16354765 12621046
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8416002989 12952375
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.108156756 2524372 14531868 11298694 12868966 8970840 18759878 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.556482804 18692083 9022650 7440962 9328219 18289764 6679447 11289319 8291058 1440618 18648102 9653073 16192314
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.6115700306 16804899
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 8.5519224547
MESH:D005234 Fatty Liver Dietary Fats 8.5517967931 18296743 19004024 19551842
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7916611131 16534752 16513791 16002989 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Cyclosporine 16.5912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 16.5918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.5920067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2016120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 16959395 15340226 18606429 8697196
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 11.8815034207
MESH:D006965 Hyperplasia Diethylstilbestrol 11.8812960047 14722030
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 4.8916002989
MESH:D007246 Infertility Diethylstilbestrol 4.6415036965
MESH:D007249 Inflammation Dietary Fats 5.2920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2912200463 12878042
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007333 Insulin Resistance Dietary Fats 3.2511836018 18457598
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.646582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.6412371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 13.6415003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3717184923
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.8115890375 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.20598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8916002989
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms Diethylstilbestrol 2.8715313581
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.6011399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.6014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009765 Obesity Dietary Fats 2.3316723640 20518802 17217161 18674790 21332399 19632207 18457598 20132043 11836018
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.5514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9816977796 15687265
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.7217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.7211896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5317136230 15046698 15846301
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Diethylstilbestrol 5.0916002989 16709447
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.061399818 6582329 7505956 6587162 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.468074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.4617306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.2616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.5514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.3515809267 16690809
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7416002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:27166 Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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