AutismKB 2.0

Annotation Detail for PJA2


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Basic Information Top
Gene Symbol:PJA2 ( KIAA0438,Neurodap1,RNF131 )
Gene Full Name: praja ring finger 2
Band: 5q21.3
Quick LinksEntrez ID:9867; OMIM: NA; Uniprot ID:PJA2_HUMAN; ENSEMBL ID: ENSG00000198961; HGNC ID: 17481
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of PJA2 mRNAdecreases expression 17327690
D000082 Acetaminophen Acetaminophen affects the expression of PJA2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PJA2 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PJA2 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of PJA2 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PJA2 mRNAdecreases expression 15576828
C056507 gemcitabine gemcitabine results in increased expression of PJA2 mRNAincreases expression 17039268
D007213 Indomethacin Indomethacin results in decreased expression of PJA2 mRNAdecreases expression 16984733
D007657 Ketone Bodies Ketone Bodies results in increased expression of PJA2 mRNAincreases expression 16807920
D001556 Lindane Lindane results in increased expression of PJA2 mRNAincreases expression 17785943
C008493 methylselenic acid methylselenic acid results in increased expression of PJA2 mRNAincreases expression 18548127
D011794 Quercetin Quercetin results in increased expression of PJA2 mRNAincreases expression 17103110
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of PJA2 mRNAincreases expression 18087596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5314692618
MESH:D000230 Adenocarcinoma Indomethacin 4.5316537180
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.6615814487
MESH:D000236 Adenoma Indomethacin 3.4911497255
MESH:D000382 Agricultural Workers' Diseases Lindane 4.4912661182
MESH:D016301 Alveolar Bone Loss Indomethacin 5.5117225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7217627676 15579461
MESH:D000743 Anemia, Hemolytic Quercetin 4.3217084956
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.9410231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.9810388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D018771 Arthralgia Indomethacin 5.302160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 5.1611248219
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 5.1619898480
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0915336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Quercetin 4.5119761891
MESH:D001477 Bartter Syndrome Indomethacin 5.0910684365
MESH:D001929 Brain Edema Indomethacin 5.1611481608
MESH:D002545 Brain Ischemia Indomethacin 4.5312524144
MESH:D001943 Breast Neoplasms gemcitabine 2.1217039268 18382427
MESH:D001943 Breast Neoplasms Indomethacin 2.1217401462
MESH:D001943 Breast Neoplasms Lindane 2.1214688026
MESH:D001943 Breast Neoplasms Quercetin 2.1218628248
MESH:D002056 Burns Indomethacin 4.8110459503
MESH:D002100 Cachexia Indomethacin 5.1215141370 16537180 11239499 15625704
MESH:D002105 Cadmium Poisoning Quercetin 5.6816962696
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 4.7416391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.7412508355 19519916
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.8411053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.4718791128 14736730 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4511212258
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0617234771
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4117341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 5.2715482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.2711212258
MESH:D006332 Cardiomegaly Quercetin 3.3619794523
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7412371664
MESH:D002764 Cholecystitis Indomethacin 5.3011181007
MESH:D002779 Cholestasis Cyclosporine 7.9819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9817681005 17110522 16919318 15861022 16105132 17333356 11677210
MESH:D003110 Colonic Neoplasms Indomethacin 4.0815625704 15936596 15786552 11260862 15963497 15637740
MESH:D003110 Colonic Neoplasms Quercetin 4.0816640504 15741050 11134977 19056647 19440933 17191121 17148506
MESH:D015179 Colorectal Neoplasms Indomethacin 2.8112606626 18059344 17054584 11197048
MESH:D015179 Colorectal Neoplasms Quercetin 2.8118852136 18095365
MESH:D018352 Coronavirus Infections Indomethacin 5.8517302372
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8019496084
MESH:D003967 Diarrhea Indomethacin 3.897907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6116081117 19923254 11287661 12392966 19739265 10774834 10915739 11529661 16109766 15619225 11739529 17562736 18713872 10663392 11461765 16177239 11743745 16485898 14725611 14550746 18071297 12594235 11421492 12540782 17906064 12958197 17522070 19420014 19416960 16393943 12705907 14986274 16781746 19370779 15968718 16227642 11834606 12153990 2444490 19085960 19164858
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.2716133044 16326151 18043480 18446180 17190690 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 4.2311991626 17045617 11595431 17329845 17202747 17151854 10671773 17351913 11535926 11595415 16699067
MESH:D004487 Edema Indomethacin 3.5816100529 7990266 8985016 8273558 7907874 19703484 10653021
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis Indomethacin 4.2215652904
MESH:D019446 Endotoxemia Indomethacin 4.6218509659
MESH:D004751 Enteritis Indomethacin 4.8810567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.0917980183
MESH:D004802 Eosinophilia Indomethacin 4.1611298111
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7120426865
MESH:D004938 Esophageal Neoplasms Indomethacin 4.7111005569
MESH:D005234 Fatty Liver Cyclosporine 7.8519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8515345470
MESH:D005334 Fever Indomethacin 4.1911852909 10431976 17627676
MESH:D005354 Fibrosarcoma Indomethacin 5.0110962813
MESH:D005355 Fibrosis Cyclosporine 15.5512639820 12168785
MESH:D005355 Fibrosis Indomethacin 15.5517994277
MESH:D005355 Fibrosis Quercetin 15.5519474275
MESH:D005499 Folliculitis Indomethacin 5.3011298111
MESH:D005756 Gastritis Acetaminophen 11.6016983495
MESH:D005756 Gastritis Indomethacin 11.6015046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Indomethacin 7.6312870263
MESH:D005909 Glioblastoma Quercetin 7.6319804834
MESH:D005910 Glioma Indomethacin 6.4218371953 16487511
MESH:D005910 Glioma Quercetin 6.4217643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.3511849393
MESH:D006073 Gout Indomethacin 5.4711248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.8015482327
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.6515633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.7815135802
MESH:D006930 Hyperalgesia Acetaminophen 8.0516870215
MESH:D006930 Hyperalgesia Indomethacin 8.0512727271
MESH:D034321 Hyperamylasemia Indomethacin 5.8517883296
MESH:D006940 Hyperemia Indomethacin 5.1212524144
MESH:D006943 Hyperglycemia Quercetin 4.1118262572 11834736
MESH:D006949 Hyperlipidemias Indomethacin 4.2517546600
MESH:D006973 Hypertension Cyclosporine 5.3910903974
MESH:D006973 Hypertension Quercetin 5.3918356687
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 5.1618306037 10574470
MESH:D007079 Ileitis Indomethacin 5.4710651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.5116133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Indomethacin 5.7912568917 7812673 3291741
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.7918590791
MESH:D007251 Influenza, Human Quercetin 4.6416624496
MESH:D007410 Intestinal Diseases Indomethacin 4.4311713966 11855677 15831440 15610444 17994277 11686837 17329856 18236018 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 5.5115241188
MESH:D007579 Jejunal Diseases Indomethacin 5.1618306037 10574470 16133968
MESH:D007627 Keloid Quercetin 5.0617086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 14.8412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.848314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 14.8417190690
MESH:D007674 Kidney Diseases Quercetin 14.8416962696
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8012371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.9712228301 11703811 10320625
MESH:D007938 Leukemia Quercetin 3.1917468513
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.9815631656 16572323 10785260
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6518360721
MESH:D007964 Leukocytosis Indomethacin 5.5116537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.8517980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.8511479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.8818194892
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.8812741479
MESH:D008107 Liver Diseases Acetaminophen 4.3412969438 16610002 16611625 19014921 19460945 12587719 11587558 19784758
MESH:D008107 Liver Diseases Lindane 4.341715830
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Quercetin 2.6918980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.1019519916
MESH:D008175 Lung Neoplasms Indomethacin 3.7611053908 16537180 11497255
MESH:D008175 Lung Neoplasms Quercetin 3.7616280456
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 3.763440675 16288123 12111688 11091918
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D008881 Migraine Disorders Indomethacin 3.7311903285
MESH:D009062 Mouth Neoplasms Indomethacin 9.3012636206
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.3015006635
MESH:D009203 Myocardial Infarction Quercetin 3.0219595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.8519207477
MESH:D009362 Neoplasm Metastasis Indomethacin 3.1916537180 11053908 11239499
MESH:D009369 Neoplasms Lindane 5.7016818664 12807735
MESH:D009369 Neoplasms Quercetin 5.7015185748
MESH:D009374 Neoplasms, Experimental Indomethacin 4.2410663608 15625704
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6318514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 8.6312349958
MESH:D020078 Neurogenic Inflammation Quercetin 4.4517929310
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.306374098
MESH:D010003 Osteoarthritis Indomethacin 3.717009135
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3119495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7519005980
MESH:D010146 Pain Acetaminophen 7.0216870215
MESH:D010146 Pain Indomethacin 7.0213679232 17627676 3291741 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.8118702446 12538197
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.8917440100 18383843 16929163 11504793 18992248
MESH:D010190 Pancreatic Neoplasms Quercetin 5.8916965848
MESH:D010195 Pancreatitis Indomethacin 4.0115028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.8516537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.1912349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.8511903285
MESH:D010437 Peptic Ulcer Indomethacin 5.2711148446
MESH:D010518 Periodontitis Indomethacin 5.0517225004
MESH:D011230 Precancerous Conditions Cyclosporine 9.3412371664
MESH:D011230 Precancerous Conditions Quercetin 9.3419056647
MESH:D047928 Premature Birth Indomethacin 5.2317000239
MESH:D011471 Prostatic Neoplasms Lindane 2.8214688026 12661182
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.8216205645
MESH:D011471 Prostatic Neoplasms Quercetin 2.8214715546 17292933
MESH:D011507 Proteinuria Indomethacin 4.2511849393
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.7318410779
MESH:D012554 Schistosomiasis japonica Quercetin 5.6816862918
MESH:D012640 Seizures Lindane 3.6715475178 7539098 12842176
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 3.5618590791
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013272 Stomach Diseases Indomethacin 4.5310192188 10486359 18209964 15472012 17638125 17160473 16184426 10215738 16113693 15038085 16280098 17207306 18545984
MESH:D013274 Stomach Neoplasms Indomethacin 2.3615609394
MESH:D013276 Stomach Ulcer Indomethacin 3.6610878458 18543354 18237397 15138204 18193104 11729361 11523592 10750652 16934674 12467913 15255614 18431645 1323529 17918041 10423059 17135157 17654042 16150113 18726076 18299717 11595415 14567935 16252198 17895592 17657623 17977527 12500499 16755016 11595431 11145282 18209962 18087811 16169175 12498302 18181030 12077510 12787963 16631530 11906479 15104355 17627676 16397915
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms Indomethacin 3.6414736730 18791128 11352223
MESH:D014456 Ulcer Indomethacin 5.0110574470 17380554
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.6816720314
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 5.6812846360
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D014839 Vomiting Indomethacin 4.8811897121
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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