AutismKB 2.0

Annotation Detail for TOMM70A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TOMM70A ( FLJ90470 )
Gene Full Name: translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
Band: 3q12.2
Quick LinksEntrez ID:9868; OMIM: 606081; Uniprot ID:TOM70_HUMAN; ENSEMBL ID: ENSG00000154174; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TOMM70A mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TOMM70A mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TOMM70A mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TOMM70A mRNAdecreases expression 19150397
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TOMM70A mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOMM70A mRNAaffects cotreatment|increases expression 17942748
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TOMM70A mRNAincreases expression 17616710
D010634 Phenobarbital Phenobarbital results in decreased expression of TOMM70A mRNAdecreases expression 19363144
C006253 pirinixic acid pirinixic acid results in increased expression of TOMM70A mRNAincreases expression 18301758
17426115
C009159 rapeseed oil rapeseed oil affects the expression of TOMM70A mRNAaffects expression 16177195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOMM70A mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TOMM70A mRNAincreases expression 17942748
D014212 Tretinoin Tretinoin results in decreased expression of TOMM70A mRNAdecreases expression 16169686
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.956195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9515322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.4717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4716835633
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4815885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.1119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.1112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.1116197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9716166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.083084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.0820935162 1701930 6705139 17173139 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.081917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.4810977129
MESH:D002386 Cataract Tretinoin 7.4817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0916919318 17333356 16105132 17110522 15861022 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9415340226 16354765 15668235 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.949407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.489211117 9125849 9224671 8800419 9142499 17551590 16925845 9664655 14991402 10589399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2616109766 17906064 19085960 18071297 16177239 12540782 2444490 11287661 11421492 19739265 17522070 11529661 19164858 12705907 12958197 16393943 16081117 10663392 16227642 10915739 19923254 11743745 12594235 14725611 14986274 18713872 15968718 16485898 11834606 19420014 10774834 11461765 15619225 14550746 19370779 16781746 19416960 11739529 12153990 12392966 17562736
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.6816714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7420426865
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7415547733 15878914 16805852 16510608 15150132 15264214 16704527 15547721 15623463
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1811564622
MESH:D005124 Eye Abnormalities Tretinoin 9.189664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0115345470
MESH:D005234 Fatty Liver pirinixic acid 8.0120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005355 Fibrosis Tretinoin 9.2117994277
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.769664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Phenobarbital 15.4416109766
MESH:D006529 Hepatomegaly pirinixic acid 15.4416221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.4415340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 15340226 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia Tretinoin 8.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.4017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2417339181 17301526 15748426 17506722 19035177 19225113 16331271 16935935 17217047 17294898 16766008 19075265 17712046 17649720 9834237 19029980 19642359 16823087 17368321 16891316 17107899 16788101 16140955 17361223 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4716248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 4.0412969438 19014921 16611625 19784758 12587719 16610002 11587558 19460945
MESH:D008107 Liver Diseases Phenobarbital 4.0419363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.077678174
MESH:D008113 Liver Neoplasms Phenobarbital 11.078742319 15975961 19812893 21047994 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 11.0720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.292876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.2918308698 1399818 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2912151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009369 Neoplasms pirinixic acid 5.1217405874
MESH:D009369 Neoplasms Tretinoin 5.1216594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 10.069125849
MESH:D009436 Neural Tube Defects Tretinoin 3.149142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3816936753
MESH:D010146 Pain Acetaminophen 6.9816870215
MESH:D010146 Pain Tretinoin 6.9816870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.752563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811399792 11896295 11222880 11118676
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3618551238
MESH:D012640 Seizures Phenobarbital 10.363137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6612958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 2.6617261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.551399818
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved