AutismKB 2.0

Annotation Detail for LRBA


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Basic Information Top
Gene Symbol:LRBA ( BGL,CDC4L,DKFZp686A09128,DKFZp686K03100,DKFZp686P2258,FLJ16600,FLJ25686,LAB300,LBA,MGC72098 )
Gene Full Name: LPS-responsive vesicle trafficking, beach and anchor containing
Band: 4q31.3
Quick LinksEntrez ID:987; OMIM: 606453; Uniprot ID:LRBA_HUMAN; ENSEMBL ID: ENSG00000198589; HGNC ID: 1742
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of LRBA mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of LRBA mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of LRBA mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LRBA proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LRBA mRNAdecreases expression 20064835
20106945
C053541 bicalutamide bicalutamide results in increased expression of LRBA mRNAincreases expression 15790403
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LRBA mRNAincreases expression 14729362
D016572 Cyclosporine Cyclosporine results in decreased expression of LRBA mRNAdecreases expression 20106945
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of LRBA mRNA]affects reaction|decreases expression 15016801
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of LRBA mRNAincreases expression 14729362
D009151 Mustard Gas Mustard Gas affects the expression of LRBA mRNAaffects expression 15651846
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5120127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.5117638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.853712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.856695378
MESH:D000740 Anemia Fluorouracil 3.8417963324 15504547 16511603
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001768 Blister Mustard Gas 5.3519167455
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1617474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 2.1616595493 19217205 18357371 15136595 18608205 16557594 16110121
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1917687719 10378619
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 3.6817121937
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.083581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.083084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.0821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.0817088986 16332177 16799960 17045692 18930000 17971768
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.697296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7616757204 16280240 17066447 18986760
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6116936243
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.706135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.707505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7012371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.229022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.2219486331
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517725105 17172411 16510598 17287894 15001691 17016597 18772588 17018589 16340194 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018288408 17454858 16391804 16524972 17255274 16303861 15289873 15148649 17594712 18509181 18448328 20501625 17016601 16282729 14970324 17401013 17094418 17695437 18949393 18383874 16331619 18802399
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9718759878 2524372 8156756 11298694 14531868 11906362 12868966 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.391440618 7440962 18692083 6679447 18289764 9653073 6482804 9022650 16192314 11289319 9328219 8291058 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3919923254 19416960 2444490 11461765 15619225 12958197 10663392 16081117 16485898 19164858 11529661 17906064 19420014 16177239 16393943 16781746 11739529 18071297 12153990 14986274 10774834 14725611 12540782 11287661 17562736 11834606 14550746 12594235 12705907 15968718 18713872 19739265 11743745 17522070 12392966 10915739 19370779 16227642 16109766 19085960 11421492
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004487 Edema Mustard Gas 3.4511428631 9260866 11428647 11402378
MESH:D004890 Erythema Mustard Gas 5.359357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.423581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.4216337965 17638652 15173087 16785472 16481741
MESH:D005234 Fatty Liver Cyclosporine 2.9919224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Cyclosporine 3.3212639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4815102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007249 Inflammation Mustard Gas 2.858975870 11428631 9260866 11428647 17524151 16001271 11428620 11402378 9357497
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.0518776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.4116518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.7616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.766582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.7612371664
MESH:D007680 Kidney Neoplasms Fluorouracil 18.7616985049
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 19014921 11587558 19460945 12587719 12969438 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.127678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.1218177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1220195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 11.1217045692 16603448 18383874 15113037
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.352876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.353712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.358603461
MESH:D008171 Lung Diseases Mustard Gas 3.5418702808 18161513
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.006695378 18816296 20135361 20464547 20869020 18520028 20064080 17053015 18569708
MESH:D008175 Lung Neoplasms Fluorouracil 5.0015246190
MESH:D008175 Lung Neoplasms Mustard Gas 5.008781369 3148597
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8918986760 16757204
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms Fluorouracil 5.2818600527 16928823 18239605
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009503 Neutropenia Mustard Gas 4.127688884 16761898
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.334026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7115113037 16929163 16500647 19003803
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.917296757
MESH:D010212 Papilloma Hydrogen Peroxide 9.9112065085
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011041 Poisoning Mustard Gas 3.9415727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6717292933
MESH:D011471 Prostatic Neoplasms bicalutamide 2.6718487222 19240160 19011039 17914592 15638997
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6719082440 18626508
MESH:D011537 Pruritus Mustard Gas 4.2918058305
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9717894541 10334151 17266442 17720292 17620002
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1415538739 18286688 16160472 18722050
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Mustard Gas 2.7415451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8910029692 19755658
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.8912065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.898532709
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.452093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4517522103 19015929 18396642 15786421 16424979 17498489 19084572 17172411 16951190 18567086
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.996582329 1399818 6587162 3712494 7505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.558074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5517053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30444
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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