AutismKB 2.0

Annotation Detail for SEC24D


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Basic Information Top
Gene Symbol:SEC24D ( FLJ43974,KIAA0755 )
Gene Full Name: SEC24 family, member D (S. cerevisiae)
Band: 4q26
Quick LinksEntrez ID:9871; OMIM: 607186; Uniprot ID:SC24D_HUMAN; ENSEMBL ID: ENSG00000150961; HGNC ID: 10706
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
Pathway IDPathway Name
Membrane Trafficking
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SEC24D mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of SEC24D mRNAdecreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of SEC24D mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of SEC24D mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of SEC24D mRNAincreases expression 18042831
D019833 Genistein Genistein results in increased expression of SEC24D mRNAincreases expression 15378649
C008493 methylselenic acid methylselenic acid affects the expression of SEC24D mRNAaffects expression 14617803
C055122 orlistat orlistat results in increased expression of SEC24D mRNAincreases expression 18796435
C041786 palm oil palm oil results in increased expression of SEC24D mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SEC24D mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Genistein 2.5111473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2720435547
MESH:D001943 Breast Neoplasms Genistein 2.2716873071 16541309 17200150
MESH:D019121 Burkholderia Infections orlistat 6.9117874328
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.763084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.7616924424
MESH:D002318 Cardiovascular Diseases Genistein 3.4216332659
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D002916 Chylothorax orlistat 6.9117003701
MESH:D003110 Colonic Neoplasms Genistein 2.3117182828
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D048909 Diabetes Complications orlistat 6.1019207292
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5216647724
MESH:D003967 Diarrhea orlistat 4.9120002075
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4414550746 12392966 12153990 18071297 2444490 11461765 11743745 11834606 10663392 12594235 11529661 17562736 19923254 16227642 17906064 19370779 18713872 16485898 10915739 19085960 15619225 19739265 11739529 16109766 19420014 19164858 11287661 16177239 12540782 14986274 12705907 15968718 12958197 16081117 10774834 14725611 16781746 17522070 16393943 19416960 11421492
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004714 Endometrial Hyperplasia Genistein 4.8316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4711473722
MESH:D005234 Fatty Liver Cyclosporine 14.0819224547
MESH:D005234 Fatty Liver Dietary Fats 14.0817967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 14.0820131406 19236843
MESH:D005355 Fibrosis Cyclosporine 9.4212168785 12639820
MESH:D005355 Fibrosis Dietary Fats 9.4218296743
MESH:D005414 Flatulence orlistat 6.9120002075
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Genistein 3.3616598420
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 10.3021332399
MESH:D006949 Hyperlipidemias orlistat 10.3021332399
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007249 Inflammation Dietary Fats 2.5120412841
MESH:D007333 Insulin Resistance Dietary Fats 13.1418457598 11836018
MESH:D007333 Insulin Resistance orlistat 13.1417201808
MESH:D007333 Insulin Resistance pirinixic acid 13.1416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.108314463 10903974 18776723
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 6.9117185156
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007938 Leukemia Genistein 3.1017468513 18980019
MESH:D008103 Liver Cirrhosis Dietary Fats 7.4918296743
MESH:D008103 Liver Cirrhosis orlistat 7.4917404856
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4817823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4815474484
MESH:D008107 Liver Diseases Acetaminophen 1.6611587558 19460945 16611625 12969438 19784758 19014921 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.607678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.6020007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.642876786 6135515 2876784
MESH:D008207 Lymphatic Metastasis orlistat 6.0820805790 18770866
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0414578162 12929590
MESH:D008545 Melanoma orlistat 3.4418770866 20805790
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009135 Muscular Diseases orlistat 11.4718430571
MESH:D009135 Muscular Diseases pirinixic acid 11.4716239165
MESH:D009164 Mycobacterium Infections orlistat 5.7621442799
MESH:D009203 Myocardial Infarction Genistein 5.8917141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.8919151258
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.8317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.8316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.157678174 18551238
MESH:D009369 Neoplasms orlistat 5.7118710210
MESH:D009369 Neoplasms pirinixic acid 5.7117405874
MESH:D009374 Neoplasms, Experimental orlistat 5.2719381703
MESH:D009389 Neovascularization, Pathologic orlistat 5.5817012255
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Genistein 4.2316427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.7317404856
MESH:D009765 Obesity Dietary Fats 7.7919632207 20518802 16723640 11836018 18457598 17217161 21332399 20132043 18674790
MESH:D009765 Obesity orlistat 7.7918773755 20002075 20065556 16938137 19461584 20518802 19207292 19046740 21442799 20540997 21438711 20599501
MESH:D009765 Obesity pirinixic acid 7.7920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D010024 Osteoporosis Genistein 3.3519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2716169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6419005980
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010195 Pancreatitis orlistat 5.0320065556 16938137
MESH:D011085 Polycystic Ovary Syndrome orlistat 5.4617201808
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011471 Prostatic Neoplasms Genistein 3.5515256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.5516205645
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012035 Refsum Disease orlistat 6.3120871815
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D013274 Stomach Neoplasms orlistat 3.2819381703
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:11123 Membrane Trafficking
REACT:17015 Metabolism of proteins
KEGG:04141 Protein processing in endoplasmic reticulum
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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