AutismKB 2.0

Annotation Detail for FCHSD2


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Basic Information Top
Gene Symbol:FCHSD2 ( KIAA0769,NWK,SH3MD3 )
Gene Full Name: FCH and double SH3 domains 2
Band: 11q13.4
Quick LinksEntrez ID:9873; OMIM: NA; Uniprot ID:FCSD2_HUMAN; ENSEMBL ID: ENSG00000137478; HGNC ID: 29114
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FCHSD2 mRNAdecreases expression 20106945
20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of FCHSD2 mRNAdecreases expression 17484886
D002117 Calcitriol Calcitriol results in increased expression of FCHSD2 mRNAincreases expression 16002434
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of FCHSD2 mRNAincreases expression 20713471
D009151 Mustard Gas Mustard Gas affects the expression of FCHSD2 mRNAaffects expression 15651846
D010634 Phenobarbital Phenobarbital results in increased expression of FCHSD2 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FCHSD2 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FCHSD2 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4415322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.306695378
MESH:D000236 Adenoma Methylcholanthrene 7.3010545420 6695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.3717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.3716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.3716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5811922910
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 2.0011237771
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0815721981 15673190 15700767 16227642 16097048 16124888 10355542 16050911 3786805 18705752 16192424 16011737
MESH:D002277 Carcinoma Methylcholanthrene 8.9810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.9816835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1418788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1420935162 20007298 6705139 17173139 1701930
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8920419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8911237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.6616192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 15340226 16354765 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9216177239 3732212 2869522 15027814 9327722 6884620 19085960 10092053 7440962 6623471 10915739 7179309 16227642 7120509 21278145 3786805 15968718 15998439 19336974 4309450 11566570 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema Mustard Gas 12.8711428647 11402378 9260866 11428631
MESH:D004487 Edema pirinixic acid 12.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.8711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2115138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.4915959796 19224547 12631006 16239168 12795759 17595544 61145 16045604
MESH:D005234 Fatty Liver pirinixic acid 8.4920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.2814633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 16.2516109766
MESH:D006529 Hepatomegaly pirinixic acid 16.2516221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.2515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 16354765 8697196 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Mustard Gas 5.4211428631 17524151 11428620 8975870 9260866 9357497 11402378 16001271 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0416221502 11408273 16239168 21278145 17174718 16943688 17334410 17157831 11903743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5114716496 20821823 16248980 17976157 18210741 18166357 12389079 18481824 17481882 16011737 15370692 18205269 16097048 18339082 12666154 18187930 15818738 15362042 17900296 18395095 15931870 18317297 14748882 17944888 18395914 18420326 17805973 18429990 15925388 15057751 18006644 18705752 15338365 15996030 18412020 14716833 17714472 16192424 18054572 12632512 16015684 17631135 18376398 17565644 17869086 15959796 16136751 12586293 17922224 15893842 17698563 15052691 18277467 15650968 18472094 18279442 17708605 14724832 14512876 17721639 12445418 12741479 17761835 16116963 14620537 18263696 18251166 15123356 16638106 10355542 17823541 16027843 18472332 12609069 12649538 11481614 16033810 17766677 12445421 12632514 12546737 17525996 18418968 12958196 15673190 12667390 18156304 13678700 15730626 17557913 15876570 12898905 17640975
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2715830285 15720792 16964402 16246199 17285989
MESH:D008107 Liver Diseases Phenobarbital 4.2719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.0820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.0819294768
MESH:D008113 Liver Neoplasms Phenobarbital 15.088742319 19482888 19073162 21047994 15975961 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 15.0816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.0816984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.3312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 15.331399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.3318308698 1399818 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.3312151625
MESH:D008171 Lung Diseases Mustard Gas 3.6018702808 18161513
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.066695378 18569708 20135361 20464547 18816296 17053015 20064080 20869020 18520028
MESH:D008175 Lung Neoplasms Methylcholanthrene 5.061399818 17909032 9230183 21163286 15390079 20512841 7750092 10545420 20970405 16271038 16337739 11893704 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 5.068781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0619555203 11884234
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009503 Neutropenia Mustard Gas 4.237688884 16761898
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11222880 11399792 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2215754350 18247401 12479363 16289102 16644109
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0017894541 17266442 17620002 17720292 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures Phenobarbital 2.843137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012871 Skin Diseases Mustard Gas 2.7616961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394562
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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