AutismKB 2.0

Annotation Detail for SMG7


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Basic Information Top
Gene Symbol:SMG7 ( C1orf16,EST1C,FLJ23717,KIAA0250,SGA56M )
Gene Full Name: Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Band: 1q25.3
Quick LinksEntrez ID:9887; OMIM: 610964; Uniprot ID:SMG7_HUMAN; ENSEMBL ID: ENSG00000116698; HGNC ID: 16792
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SMG7 mRNAaffects expression 21346803
D012643 Selenium Selenium results in increased expression of SMG7 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7916705839
MESH:D003092 Colitis Selenium 4.5417936198
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.7818551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 4.3015131321
MESH:D006333 Heart Failure Selenium 3.3417162251
MESH:D007251 Influenza, Human Selenium 5.2716624496
MESH:D007676 Kidney Failure, Chronic Selenium 4.4416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.4116705839
MESH:D008325 Mammary Neoplasms, Experimental Selenium 3.0515318939
MESH:D008654 Mesothelioma Selenium 2.9415107826
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.7418551238
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.9316049721 12819281
MESH:D010954 Plasmacytoma Selenium 5.9615087411
MESH:D012640 Seizures 2,4-dinitrotoluene 2.8518551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.4316049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 5.2010091137
Pathway ID Pathway Name
KEGG:03015 mRNA surveillance pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018