AutismKB 2.0

Annotation Detail for NUAK1


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Basic Information Top
Gene Symbol:NUAK1 ( ARK5,KIAA0537 )
Gene Full Name: NUAK family, SNF1-like kinase, 1
Band: 12q23.3
Quick LinksEntrez ID:9891; OMIM: 608130; Uniprot ID:NUAK1_HUMAN; ENSEMBL ID: ENSG00000074590; HGNC ID: 14311
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of NUAK1 mRNAdecreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NUAK1 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NUAK1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of NUAK1 mRNAdecreases expression 20106945
D007213 Indomethacin Indomethacin results in increased expression of NUAK1 mRNAincreases expression 16984733
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NUAK1 mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene Raloxifene affects the expression of NUAK1 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NUAK1 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7911798837 19825857
MESH:D000230 Adenocarcinoma Indomethacin 4.7916537180
MESH:D000236 Adenoma Indomethacin 3.5611497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000419 Albuminuria Raloxifene 4.8317308373 17451421
MESH:D016301 Alveolar Bone Loss Indomethacin 5.6917225004
MESH:D000544 Alzheimer Disease Indomethacin 4.6115579461 17627676
MESH:D000544 Alzheimer Disease Raloxifene 4.6115800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001014 Aortic Aneurysm Indomethacin 5.0910231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.1310388637
MESH:D018771 Arthralgia Indomethacin 5.492160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8611248219
MESH:D001477 Bartter Syndrome Indomethacin 5.2410684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.5216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.5219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.5212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001929 Brain Edema Indomethacin 5.3411481608
MESH:D001930 Brain Injuries Raloxifene 4.7316580743
MESH:D002545 Brain Ischemia Indomethacin 4.7012524144
MESH:D001943 Breast Neoplasms Indomethacin 2.0017401462
MESH:D001943 Breast Neoplasms Raloxifene 2.0017049068 17893378 17242785 15758505 16837676 16912660 15775269 15572757 17595753 17952589 17440819 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 2.0020065188 20390343 19103187 17049068 19244106 15565566 19059307 18855134 19288272 19084267 19289846 19189212 18997820 21138602 18425577 19115204 20859285 20135344 16273361 19011961 17242785 19142967 18629630 20544844 19066611 18351453 17440819 17261762 20005174 19410462 18984771 17893378 19200415 11161223 21152245 15668708 16873071 18815881 19155303 16202921 16818667 19189210 18821012 19487384 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002056 Burns Indomethacin 4.9610459503
MESH:D002100 Cachexia Indomethacin 5.2915141370 15625704 11239499 16537180
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0410355542 16011737 15721981 18705752 15700767 16124888 15673190 16050911 16227642 3786805 16097048 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8416217749 11135700 14691202 15073043 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8418788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 6.8416391822
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8416924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.0111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.6411352223 18791128 14736730
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4617341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.9012636206 15482327
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.1517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.1517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5815775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0112371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002764 Cholecystitis Indomethacin 5.4911181007
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 15668235 15340226 16354765 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.8815800139
MESH:D003110 Colonic Neoplasms Indomethacin 2.6215963497 15637740 15625704 15936596 15786552 11260862
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7220501625
MESH:D015179 Colorectal Neoplasms Indomethacin 2.7211197048 12606626 18059344 17054584
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D018352 Coronavirus Infections Indomethacin 6.0417302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 10048152 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.6517308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6519279558
MESH:D003967 Diarrhea Indomethacin 4.037907874 7237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.894309450 6884620 2869522 7120509 16177239 11566570 19336974 6623471 16227642 15998439 15968718 21278145 9327722 15027814 7440962 3786805 17522070 10915739 19085960 7179309 3732212 10092053
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.4316133044 17190690 16326151 18043480 12774134 18446180
MESH:D004381 Duodenal Ulcer Indomethacin 4.3717351913 17045617 17202747 10671773 16699067 17151854 11535926 11991626 17329845 11595431 11595415
MESH:D004487 Edema Indomethacin 18.2416100529 10653021 7907874 8985016 19703484 7990266 8273558
MESH:D004487 Edema pirinixic acid 18.2412083418
MESH:D004487 Edema Raloxifene 18.2415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 18.2411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.0515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1716202921 19155303 20544844 17893378
MESH:D004715 Endometriosis Indomethacin 9.7215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.729294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.7818509659
MESH:D004751 Enteritis Indomethacin 5.0610567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.2417980183
MESH:D004802 Eosinophilia Indomethacin 4.3111298111
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5912903497
MESH:D004938 Esophageal Neoplasms Indomethacin 7.5911005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 33.7215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.7216239168 19224547 15959796 17595544 12631006 12795759 16045604 61145
MESH:D005234 Fatty Liver Cyclosporine 33.7219224547
MESH:D005234 Fatty Liver pirinixic acid 33.7219236843 20131406
MESH:D005234 Fatty Liver Raloxifene 33.7217473493
MESH:D005234 Fatty Liver Tamoxifen 33.7214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005334 Fever Indomethacin 4.3111852909 17627676 10431976
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005354 Fibrosarcoma Indomethacin 5.1810962813
MESH:D005355 Fibrosis Carbon Tetrachloride 23.4718705752
MESH:D005355 Fibrosis Cyclosporine 23.4712168785 12639820
MESH:D005355 Fibrosis Indomethacin 23.4717994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.4720067830
MESH:D005499 Folliculitis Indomethacin 5.4911298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005756 Gastritis Indomethacin 5.0615046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Indomethacin 3.6912870263
MESH:D005910 Glioma Indomethacin 3.2918371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.4511849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006073 Gout Indomethacin 5.6411248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.8715482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.6711110106
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.7815633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319110552 19900420
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.9215135802
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3618606429 16959395 8697196 16354765 15340226
MESH:D006930 Hyperalgesia Indomethacin 3.9312727271
MESH:D034321 Hyperamylasemia Indomethacin 6.0417883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006940 Hyperemia Indomethacin 5.2912524144
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Indomethacin 4.3817546600
MESH:D006973 Hypertension Cyclosporine 8.9810903974
MESH:D006973 Hypertension Raloxifene 8.9815787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007077 Ileal Diseases Indomethacin 5.3410574470 18306037
MESH:D007079 Ileitis Indomethacin 5.6410647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.6916133044
MESH:D007249 Inflammation Indomethacin 8.9312568917 3291741 7812673
MESH:D007249 Inflammation Tamoxifen 8.9319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007410 Intestinal Diseases Indomethacin 4.5815831440 17994277 11686837 17329856 18236018 11713966 11855677 15610444 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 5.6915241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007579 Jejunal Diseases Indomethacin 5.3410574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.558314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 6.5517190690
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.8818625569
MESH:D007889 Leiomyoma Raloxifene 4.7216973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.0710320625 12228301 11703811
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 9.0614633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 9.0610785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1920471514 16968895 16467208 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.1918360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3416331271 16891316 15748426 11161223 19642359 17649720 19225113 16823087 16966277 12712474 16330433 9834237 17217047 11468182 12018890 16112521 15622746 19075265 19035177 17712046 15336539 17869043 17107899 15213294 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D007964 Leukocytosis Indomethacin 5.6916537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.0417980183
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.0411479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9121278145 11408273 17334410 16943688 17157831 17174718 16239168 11903743 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.9612741479 17698563 16192424 18277467 18205269 12389079 14724832 18420326 17944888 12632514 17557913 18054572 17766677 18472094 18339082 17869086 16027843 12649538 18317297 17481882 18705752 17922224 15818738 18263696 15052691 18210741 17640975 15673190 17721639 15338365 18429990 16015684 11481614 15959796 16116963 14716833 17900296 17708605 18279442 18251166 12546737 18376398 15893842 12445418 16097048 17714472 15057751 12609069 18187930 18395095 12898905 16033810 12445421 15370692 17631135 14512876 18166357 17823541 15362042 12666154 18395914 15730626 18481824 17976157 15123356 16136751 12667390 14748882 18412020 15931870 18156304 14716496 15996030 17805973 15650968 16011737 13678700 17761835 18418968 18472332 10355542 14620537 17565644 18006644 15876570 16638106 20821823 15925388 12958196 16248980 12586293 17525996 12632512
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.9618194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.9615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.9618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.9612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216246199 17285989 15720792 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8816899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 14.9714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.9719294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.9715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 14.9716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5220377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.5215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0319825857 11798837
MESH:D008175 Lung Neoplasms Indomethacin 5.0311497255 16537180 11053908
MESH:D008175 Lung Neoplasms Tamoxifen 5.0318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0319555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7414580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D008881 Migraine Disorders Indomethacin 3.8211903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8715863610
MESH:D009062 Mouth Neoplasms Indomethacin 4.1412636206
MESH:D009101 Multiple Myeloma arsenic trioxide 7.8919417148 19549372 15949261 14977855 11468182
MESH:D009101 Multiple Myeloma Raloxifene 7.8916497877
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009232 Myxoma Raloxifene 5.8716343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis Indomethacin 6.1911053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.1919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.3915625704 10663608
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.1112349958
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.496374098
MESH:D010003 Osteoarthritis Indomethacin 3.787009135
MESH:D010024 Osteoporosis Raloxifene 3.5117882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4517893378 15579764 17823083 15758505
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4612452020 16624393 19769630
MESH:D010146 Pain Indomethacin 3.633291741 17627676 13679232 17440234
MESH:D010149 Pain, Postoperative Indomethacin 5.0018702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010195 Pancreatitis Indomethacin 4.1417883296 15028970
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.0416537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.3112349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.0411903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010437 Peptic Ulcer Indomethacin 5.4311148446
MESH:D010518 Periodontitis Indomethacin 5.2317225004
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D047928 Premature Birth Indomethacin 5.3917000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5819131511
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5815731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5815067354
MESH:D011507 Proteinuria Indomethacin 4.3811849393
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011693 Purpura Raloxifene 5.8715770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Tamoxifen 4.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013272 Stomach Diseases Indomethacin 4.7015038085 18209964 10486359 16184426 10215738 17207306 15472012 10192188 17160473 18545984 16113693 17638125 16280098
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7017007042
MESH:D013274 Stomach Neoplasms Indomethacin 2.7015609394
MESH:D013276 Stomach Ulcer Indomethacin 3.7912077510 11523592 12498302 16631530 16755016 12500499 15138204 10878458 12467913 18193104 17895592 10423059 17918041 16252198 10750652 17977527 18299717 16169175 16397915 17657623 1323529 18087811 16150113 16934674 11729361 15255614 11906479 11595431 15104355 18181030 14567935 17654042 18543354 18726076 17135157 18209962 18431645 18237397 17627676 12787963 11145282 11595415
MESH:D020521 Stroke Raloxifene 3.9816837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9419014326
MESH:D013964 Thyroid Neoplasms Indomethacin 7.9411352223 14736730 18791128
MESH:D013978 Tibial Fractures Raloxifene 5.5319048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D014456 Ulcer Indomethacin 5.1810574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.8012845720 11780464 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.8017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8016712894 17572228 8653321
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5316837676
MESH:D014839 Vomiting Indomethacin 5.0611897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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