AutismKB 2.0

Annotation Detail for SV2B


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Basic Information Top
Gene Symbol:SV2B ( FLJ30413,FLJ42732,HsT19680,KIAA0735 )
Gene Full Name: synaptic vesicle glycoprotein 2B
Band: 15q26.1
Quick LinksEntrez ID:9899; OMIM: 185861; Uniprot ID:SV2B_HUMAN; ENSEMBL ID: ENSG00000185518; HGNC ID: 16874
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04512ECM-receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
serum metabolites
Desease Name
Serum metabolites
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SV2B mRNAaffects expression 16483693
C058317 arsenic disulfide arsenic disulfide results in decreased expression of SV2B mRNAdecreases expression 12890387
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of SV2B mRNAincreases expression 15912405
D001761 Bleomycin Bleomycin results in increased expression of SV2B mRNAincreases expression 15808516
D002713 Chlorine Chlorine results in increased expression of SV2B mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of SV2B mRNAaffects cotreatment|increases expression 18636392
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SV2B mRNAaffects cotreatment|decreases expression 18606552
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SV2B mRNAincreases expression 17108234
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SV2B mRNAaffects cotreatment|decreases expression 18606552
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of SV2B mRNAaffects cotreatment|increases expression 18636392
D012402 Rotenone Rotenone results in decreased expression of SV2B mRNAdecreases expression 19013527
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury Bleomycin 10.4217118201
MESH:D055371 Acute Lung Injury Chlorine 10.4220601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000544 Alzheimer Disease Ozone 2.4715513908
MESH:D000860 Anoxia Bleomycin 5.6415782499
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5915570426
MESH:D001249 Asthma Ozone 2.6816373670 17854713
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8118417511 18315731 14754758 15516495 19059883 16777450 17626835
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 3.646189445
MESH:D009202 Cardiomyopathies Zalcitabine 4.8210591146
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0016105132 17333356 17681005 15861022 16919318 11677210 17110522
MESH:D004362 Drug Toxicity Zalcitabine 4.977515130
MESH:D004417 Dyspnea Chlorine 4.8920016425
MESH:D004487 Edema Bleomycin 4.4217118201
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.8515345470
MESH:D005234 Fatty Liver Zalcitabine 8.8518299183
MESH:D005739 Gas Poisoning Chlorine 5.2720016425
MESH:D015658 HIV Infections Zalcitabine 4.4217457083
MESH:D006689 Hodgkin Disease Bleomycin 4.5215147373 17606976 18501091
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Bleomycin 3.8017118201
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 5.0312421474
MESH:D008171 Lung Diseases Ozone 3.498266340 19066396
MESH:D055370 Lung Injury Ozone 4.0620417186
MESH:D008175 Lung Neoplasms Bleomycin 3.116189445
MESH:D008175 Lung Neoplasms Ozone 3.117614698 8597069
MESH:D008223 Lymphoma Zalcitabine 4.769488045 8764131 18798262 17941976 9205081 11980663 8840982
MESH:D008545 Melanoma Bleomycin 3.2715577320
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D009374 Neoplasms, Experimental Zalcitabine 5.318764131 9205081 9488045
MESH:D009410 Nerve Degeneration Rotenone 4.0117356569 15790535 18619942
MESH:D009437 Neuralgia Zalcitabine 6.5517292584
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010300 Parkinson Disease Rotenone 3.0311445065 15451049 18619942 16140633 16412576 18191903 11535288 19232380 19114014
MESH:D020734 Parkinsonian Disorders Rotenone 4.2415927086 15574749 15795934 18197244
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 11.6118606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 11.6118606552
MESH:D010538 Peritonitis Ozone 4.3516369182
MESH:D011014 Pneumonia Bleomycin 12.2216317386 17071938 18024389
MESH:D011014 Pneumonia Ozone 12.2218381685 18929643 18007984
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011654 Pulmonary Edema Bleomycin 5.5815808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.9215541506 18008008 17177178 14609568 18162602 17241526 21435439 11554783 15322207 12624602 16314464 12574379 17434272 16115399
MESH:D012120 Respiration Disorders Chlorine 5.4818579056
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D015431 Weight Loss Bleomycin 5.8812624602
Pathway ID Pathway Name
KEGG:04512 ECM-receptor interaction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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