AutismKB 2.0

Annotation Detail for KLHL21


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Basic Information Top
Gene Symbol:KLHL21 ( KIAA0469,MGC99635 )
Gene Full Name: kelch-like 21 (Drosophila)
Band: 1p36.31
Quick LinksEntrez ID:9903; OMIM: NA; Uniprot ID:KLH21_HUMAN; ENSEMBL ID: ENSG00000162413; HGNC ID: 29041
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KLHL21 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of KLHL21 mRNAincreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLHL21 mRNAdecreases expression 19150397
D003474 Curcumin Curcumin results in increased expression of KLHL21 mRNAincreases expression 17198877
D016572 Cyclosporine Cyclosporine results in increased expression of KLHL21 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of KLHL21 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of KLHL21 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of KLHL21 mRNAincreases expression 19270015
C025462 sulindac sulfide sulindac sulfide results in increased expression of KLHL21 mRNAincreases expression 16184548
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.2617620307
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4017887948
MESH:D000544 Alzheimer Disease Curcumin 4.7815590663
MESH:D000544 Alzheimer Disease sulindac sulfide 4.7818759972
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7716807698
MESH:D050197 Atherosclerosis Curcumin 3.4318704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.7519761891
MESH:D002545 Brain Ischemia Curcumin 4.6116770732
MESH:D001932 Brain Neoplasms Curcumin 4.1317596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9420146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 1.9418462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Dietary Fats 1.9420435547
MESH:D002277 Carcinoma Curcumin 4.0018593918
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.961701930 17173139 20935162 20007298 6705139
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 6.1418414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 6.1412391285
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9120419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.9118462866
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0112371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D003092 Colitis Curcumin 4.4316782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.7618809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.1618497527
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7418403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.1918204486
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6315619225 14725611 10774834 19085960 16485898 16109766 12540782 16227642 19164858 11287661 18713872 14986274 12153990 16177239 2444490 10915739 11529661 15968718 19420014 17906064 11743745 12958197 19923254 11421492 11739529 12705907 10663392 11834606 16393943 16781746 19370779 19739265 17562736 17522070 14550746 19416960 12594235 12392966 16081117 18071297 11461765
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004381 Duodenal Ulcer Curcumin 4.2817351913
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5016530937
MESH:D005234 Fatty Liver Curcumin 14.4219297423
MESH:D005234 Fatty Liver Cyclosporine 14.4219224547
MESH:D005234 Fatty Liver Dietary Fats 14.4218296743 19004024 19551842 17967931
MESH:D005355 Fibrosis Curcumin 16.4418705752
MESH:D005355 Fibrosis Cyclosporine 16.4412639820 12168785
MESH:D005355 Fibrosis Dietary Fats 16.4418296743
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.9518462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Curcumin 3.6017596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7918829502 18462866
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly Phenobarbital 3.7416109766
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3017701891
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Curcumin 9.9318704882
MESH:D006937 Hypercholesterolemia Dietary Fats 9.9321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007249 Inflammation Curcumin 5.6217151092 18403477 16956363
MESH:D007249 Inflammation Dietary Fats 5.6220412841
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2818596194 18200517
MESH:D007333 Insulin Resistance Dietary Fats 3.2311836018 18457598
MESH:D007414 Intestinal Neoplasms Curcumin 4.4110783313
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.1618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007889 Leiomyoma Curcumin 4.7918555241
MESH:D007938 Leukemia Curcumin 3.3318462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4116106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0016106398
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0118296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0121047994
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.2817355460 18705752 18006644
MESH:D008107 Liver Diseases Acetaminophen 6.8219460945 16610002 19784758 16611625 19014921 12587719 12969438 11587558
MESH:D008107 Liver Diseases Curcumin 6.8216956363
MESH:D008107 Liver Diseases Phenobarbital 6.8219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7721137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 4.7719812893 8742319 21047994 19073162 15975961 19482888
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.826150874 1399818 18308698 2563599 17172636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.616695378 18816296 20135361 20464547 20869020 18569708 20064080 17053015 18520028
MESH:D008175 Lung Neoplasms Curcumin 2.6118462866 19359593 16243823
MESH:D008223 Lymphoma Curcumin 3.7318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.9516173963
MESH:D008545 Melanoma Curcumin 2.4418462866 17885582
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008569 Memory Disorders Curcumin 4.3917263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009101 Multiple Myeloma Curcumin 3.6519372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2017962980
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6118495463
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.8512497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009423 Nervous System Neoplasms Curcumin 5.9518462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Curcumin 4.9219297423
MESH:D009765 Obesity Dietary Fats 4.9217217161 18674790 18457598 20518802 21332399 20132043 11836018 16723640 19632207
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010024 Osteoporosis Curcumin 3.5918719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8718462866 19020741
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.6619196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6616965848
MESH:D011230 Precancerous Conditions Cyclosporine 9.5912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.592563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2817292933
MESH:D011471 Prostatic Neoplasms Curcumin 3.2811398177 10851300 15129424 18769126 18226269 12497104 18156803
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.7219168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2510666014 18379247
MESH:D012509 Sarcoma Curcumin 4.3118462866
MESH:D012640 Seizures Phenobarbital 2.823137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D018805 Sepsis Curcumin 4.2518389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4510029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Curcumin 3.7019188055 16631530
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.211399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4317053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.4318593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.5518462866
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.8918645019
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134989246
    • No data
    Releated disease ID Related disease Name
    PA446329Motor Neuron Disease
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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