AutismKB 2.0

Annotation Detail for G3BP2


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Basic Information Top
Gene Symbol:G3BP2 ( - )
Gene Full Name: GTPase activating protein (SH3 domain) binding protein 2
Band: 4q21.1
Quick LinksEntrez ID:9908; OMIM: NA; Uniprot ID:G3BP2_HUMAN; ENSEMBL ID: ENSG00000138757; HGNC ID: 30291
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by Rho GTPases
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of G3BP2 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of G3BP2 mRNAincreases expression 20498004
D004958 Estradiol Estradiol affects the expression of G3BP2 mRNAaffects expression 15598610
D014212 Tretinoin Tretinoin results in decreased expression of G3BP2 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5420464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.5411473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D000505 Alopecia Tretinoin 3.9415955085
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.3016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.9116935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0316197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8620146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.8617289903 17018787 16675129 17261762 12948864 14630087 18497071 19861407
MESH:D001943 Breast Neoplasms Tretinoin 1.8616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.2216813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.8816168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.151917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8720419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8716051514 16096774
MESH:D002386 Cataract Tretinoin 3.3017460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0318566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.2216129372
MESH:D002822 Choriocarcinoma Tretinoin 5.8816461808
MESH:D002972 Cleft Palate Tretinoin 2.809407595
MESH:D003092 Colitis Tretinoin 4.2617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9211117 16925845 14991402 17551590 9224671 8800419 9142499 9664655 9125849
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D004489 Edema, Cardiac Tretinoin 5.1918230668
MESH:D016889 Endometrial Neoplasms Estradiol 8.2311473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 8.2316569247
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005124 Eye Abnormalities Tretinoin 3.879664655 16938888
MESH:D005355 Fibrosis Tretinoin 4.0717994277
MESH:D005909 Glioblastoma Tretinoin 3.2417312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.8816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.2620471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.269664655 14991402
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006930 Hyperalgesia Tretinoin 3.5316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.1316778211
MESH:D007333 Insulin Resistance Estradiol 3.2116393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 4.3317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3317551590 15992940
MESH:D007674 Kidney Diseases Estradiol 2.7815618244
MESH:D007680 Kidney Neoplasms Estradiol 3.3215610895
MESH:D007938 Leukemia Tretinoin 2.9317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1219285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3916935935 17107899 19029980 16788101 19225113 19642359 16140955 9834237 17301526 16891316 12679006 17294898 17506722 17649720 16766008 17712046 16331271 19035177 17368321 19075265 15748426 16823087 17217047 17361223 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.589224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5618397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1520195826 21137059
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.5817365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718816296 6695378 20464547 20135361 18569708 20869020 18520028 20064080 17053015
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7911807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D008527 Medulloblastoma Tretinoin 2.9117453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9916940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.3118303189 16166281 16966607
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2817596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5916810080
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5611141357
MESH:D009369 Neoplasms Tretinoin 5.5616946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009421 Nervous System Malformations Estradiol 11.4116427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 11.419125849
MESH:D009436 Neural Tube Defects Tretinoin 3.299142499
MESH:D010051 Ovarian Neoplasms Estradiol 5.1319401270
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1316936753
MESH:D010146 Pain Tretinoin 3.2416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5715976015
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.4510923243
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0317292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D011507 Proteinuria Tretinoin 4.0716636307
MESH:D011625 Pterygium Tretinoin 5.4216723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1517322281 17365031 17975199 15814490
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5616283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.2119755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 6.2116467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4220155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.4217261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.4516040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.3316752155
MESH:D014820 Vitiligo Tretinoin 4.5616761959
MESH:D009396 Wilms Tumor Tretinoin 4.3416287080
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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