AutismKB 2.0

Annotation Detail for SEC16A


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Basic Information Top
Gene Symbol:SEC16A ( FLJ26737,KIAA0310,RP11-413M3.10,SEC16L,p250 )
Gene Full Name: SEC16 homolog A (S. cerevisiae)
Band: 9q34.3
Quick LinksEntrez ID:9919; OMIM: 612854; Uniprot ID:SC16A_HUMAN; ENSEMBL ID: ENSG00000148396; HGNC ID: 29006
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SEC16A mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in decreased expression of SEC16A mRNAdecreases expression 15223131
C006780 bisphenol A ESR1 protein affects the reaction [bisphenol A results in decreased expression of SEC16A mRNA]affects reaction|decreases expression 15223131
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in decreased expression of SEC16A mRNA]affects reaction|decreases expression 15223131
D004958 Estradiol Estradiol results in decreased expression of SEC16A mRNAdecreases expression 15223131
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in increased expression of SEC16A mRNAincreases expression 17616710
D012643 Selenium Selenium results in decreased expression of SEC16A mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of SEC16A mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D001862 Bone Resorption bisphenol A 4.1911985600
MESH:D001943 Breast Neoplasms bisphenol A 2.1917123778
MESH:D001943 Breast Neoplasms Estradiol 2.1917261762 12948864 17289903 19861407 14630087 16675129 17018787 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.4517123778
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3520889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.3518566989
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.7320423518
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2415131321
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D016889 Endometrial Neoplasms Estradiol 3.1711473722 18566989 19148513
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1316080930
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 11.8517088409
MESH:D019584 Hot Flashes Vitamin E 11.8514716179
MESH:D007251 Influenza, Human Selenium 12.7616624496
MESH:D007251 Influenza, Human Vitamin E 12.7616624496
MESH:D007333 Insulin Resistance bisphenol A 8.0816393666
MESH:D007333 Insulin Resistance Estradiol 8.0816393666 16627594
MESH:D007674 Kidney Diseases Estradiol 6.6615618244
MESH:D007674 Kidney Diseases Vitamin E 6.6612488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms Estradiol 3.2415610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5816169303
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6611408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6615318939
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009421 Nervous System Malformations bisphenol A 11.0416427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 11.0416427766 11399458
MESH:D010049 Ovarian Diseases bisphenol A 5.4511985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.4110548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.6620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.6620887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5316740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.5316740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5315084515
MESH:D011629 Puberty, Precocious bisphenol A 5.2510548101
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.4516684133 16045194
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.4115864552
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D014591 Uterine Diseases bisphenol A 5.5314652134
Pathway ID Pathway Name
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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