AutismKB 2.0

Annotation Detail for KBTBD11


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Basic Information Top
Gene Symbol:KBTBD11 ( KIAA0711,KLHDC7C )
Gene Full Name: kelch repeat and BTB (POZ) domain containing 11
Band: 8p23.3
Quick LinksEntrez ID:9920; OMIM: NA; Uniprot ID:KBTBB_HUMAN; ENSEMBL ID: ENSG00000176595; HGNC ID: 29104
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of KBTBD11 mRNAincreases expression 19933214
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of KBTBD11 mRNAincreases expression 16788091
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of KBTBD11 mRNAdecreases expression 20064835
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of KBTBD11 mRNAdecreases expression 17403535
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of KBTBD11 mRNAaffects cotreatment|increases expression 17404688
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KBTBD11 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of KBTBD11 mRNAincreases expression 18301758
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of KBTBD11 mRNAaffects cotreatment|increases expression 17404688
D018038 Sodium Selenite Sodium Selenite results in increased expression of KBTBD11 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KBTBD11 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4311473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.8615014928
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3920146248 17474063
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.3918323546 17388661 12006526 11325840 17020986 15093573 16978400 18234424 15136595
MESH:D001943 Breast Neoplasms Estradiol 2.3916675129 12948864 19861407 17289903 18497071 14630087 17018787 17261762
MESH:D001943 Breast Neoplasms Progesterone 2.3917614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.3519701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.3516924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.1716152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.6216201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9118566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 8697196 12621046 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003556 Cystitis Cyclophosphamide 5.3017979934 11948286 18710439 15643279 16651033 10498854 10700343 16413132 12161096 16614059 18483878 16989017 18295254 12913760 17010015 18372110 18433785 12388444 18093676 15276878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2415331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2718772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 3.9815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0217692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.1111473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 9.5816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.5810568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 4.4711006010
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver pirinixic acid 2.9720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D018316 Gliosarcoma Cyclophosphamide 5.8011389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2916376943 15172196 11014644
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006467 Hemophilia A Cyclophosphamide 5.5511918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.8514986274
MESH:D006529 Hepatomegaly pirinixic acid 9.1419772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.9616135485 17606976
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 18606429 8697196 16354765 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007154 Immune System Diseases Cyclophosphamide 5.6516076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007248 Infertility, Male Cyclophosphamide 3.757193160 16517039
MESH:D007249 Inflammation Progesterone 5.3015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 13.0716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 13.0716306350
MESH:D007333 Insulin Resistance Sodium Selenite 13.0714714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Estradiol 2.6915618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1515610895
MESH:D007938 Leukemia Cyclophosphamide 3.5810602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5718587576 17802794 17296974 18172266 17658394 17008537
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2410373061
MESH:D007970 Leukopenia Cyclophosphamide 5.2510052129 11830472
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7121137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.7120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2318520028 18816296 20064080 18569708 20135361 20464547 20869020 6695378 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2311884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 3.9812854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 11.1316675587
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 11.1314737004
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.3411911406
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4811807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4817203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.0616388313
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7816411023
MESH:D009369 Neoplasms Benzo(a)pyrene 8.8311141357
MESH:D009369 Neoplasms Cyclophosphamide 8.8318854779
MESH:D009369 Neoplasms pirinixic acid 8.8317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 10.2711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2714600291
MESH:D009447 Neuroblastoma Cyclophosphamide 3.738761367 15176712 16115947
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.1712837982 8761367
MESH:D009503 Neutropenia Cyclophosphamide 4.548291058
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009845 Oligospermia Cyclophosphamide 5.0016517039
MESH:D010051 Ovarian Neoplasms Estradiol 5.0519401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.0516525653 17393432
MESH:D010146 Pain Cyclophosphamide 3.7918093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.2411332152
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9121297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811222880 11399792 11118676 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.0717136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0718760546
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3516636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0416636934
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.8016517039
MESH:D013119 Spinal Cord Injuries Progesterone 4.5615862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.3412837982
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5217053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.5214692829
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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