AutismKB 2.0

Annotation Detail for MAFB


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Basic Information Top
Gene Symbol:MAFB ( KRML,MGC43127 )
Gene Full Name: v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
Band: 20q12
Quick LinksEntrez ID:9935; OMIM: 608968; Uniprot ID:MAFB_HUMAN; ENSEMBL ID: ENSG00000204103; HGNC ID: 6408
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
PHARMACOGENOMIC
response to TNF antagonist treatment
METABOLIC
LDL cholesterol
Desease Name
LDL cholesterol
Response to TNF antagonist treatment
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MAFB mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MAFB mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MAFB mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAFB mRNAaffects expression 16483693
D001194 Asbestos Asbestos affects the expression of MAFB mRNAaffects expression 17297452
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAFB mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MAFB mRNAincreases expression 20382639
19150397
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MAFB mRNAincreases expression 15171707
D002117 Calcitriol Calcitriol results in increased expression of MAFB mRNAincreases expression 16002434
D005419 Flavonoids Flavonoids results in increased expression of MAFB mRNAincreases expression 18035473
C106014 gedunin gedunin results in decreased expression of MAFB mRNAdecreases expression 17010675
D019833 Genistein Genistein results in increased expression of MAFB mRNAincreases expression 18847459
C533894 LG 100815 LG 100815 results in decreased expression of MAFB mRNAdecreases expression 16951191
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of MAFB mRNAincreases expression 12057914
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of MAFB mRNAincreases expression 20024957
C044361 M-VAC protocol MAFB protein results in increased susceptibility to M-VAC protocolincreases response to substance 15814643
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of MAFB mRNAdecreases expression 16951191
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MAFB mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of MAFB mRNAdecreases expression 19482888
19270015
D010634 Phenobarbital Phenobarbital results in increased expression of MAFB mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAFB mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of MAFB mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of MAFB mRNAincreases expression 18445702
C009250 sevoflurane sevoflurane affects the expression of MAFB mRNAaffects expression 15967596
C009277 sodium arsenate sodium arsenate results in decreased expression of MAFB mRNAdecreases expression 16882884
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MAFB mRNAdecreases expression 17517823
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MAFB mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAFB mRNAincreases expression 17275934
D013849 Thimerosal Thimerosal results in increased expression of MAFB mRNAincreases expression 16870260
C050414 tripterine tripterine results in decreased expression of MAFB mRNAdecreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.796195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7915322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.5718653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.5718653653
MESH:D000230 Adenocarcinoma Genistein 2.4411473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.4017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.4016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.4016835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3315469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D050197 Atherosclerosis Asbestos 4.1318795166
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001943 Breast Neoplasms Calcitriol 1.9611237771
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9615324884 17129689
MESH:D001943 Breast Neoplasms Genistein 1.9616541309 16873071 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.6216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6216705839
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.6216924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.6216924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.6217173139 20007298 1701930 6705139 20935162
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.5811237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.2016332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.726135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.7220889678
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 10.7219716837
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.104080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis pirinixic acid 2.7119176532
MESH:D002971 Cleft Lip marker/mechanism 20436469
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 16354765 15340226 12621046 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.2617182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.7310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7310048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4116002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.3918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.3918551238
MESH:D017449 Dermatitis, Allergic Contact Thimerosal 4.3916958921 15932584
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D002658 Developmental Disabilities Thimerosal 4.7415764492
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.6321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.6321346803 18551238
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 8.6318186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004421 Dystonia Phenobarbital 3.861851702
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.7915138306
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.3816402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.3816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.3615700306 16804899
MESH:D016889 Endometrial Neoplasms Genistein 7.3611473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2415328337 17637181 15821434
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.963659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.723922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.107750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.873659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0420426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver pirinixic acid 2.6320131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5616002989 16513791 16534752 16611131 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005334 Fever Lipopolysaccharides 3.889205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8020067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7916452187
MESH:D005909 Glioblastoma Genistein 3.1616598420
MESH:D018149 Glucose Intolerance sodium arsenate 4.9419446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2516366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006529 Hepatomegaly Phenobarbital 13.5116109766
MESH:D006529 Hepatomegaly pirinixic acid 13.5118467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916959395 15340226 18606429 8697196 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2914722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8518670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 4.4316002989
MESH:D007246 Infertility Diethylstilbestrol 4.2115036965
MESH:D007249 Inflammation Flavonoids 7.9217296493
MESH:D007249 Inflammation Lipopolysaccharides 7.9217255318 17237260 17963957 12878042 9205823
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.7414681315 15003126 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 9.4917184923
MESH:D007859 Learning Disorders sevoflurane 9.4919212262
MESH:D007938 Leukemia Genistein 2.9517468513 18980019
MESH:D007970 Leukopenia Lipopolysaccharides 4.5515821434
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8121047994
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.8117823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 4.8112878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8112878042
MESH:D008107 Liver Diseases Phenobarbital 2.1419363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.627678174
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.6216712894 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 13.628742319 19812893 15975961 19482888 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 13.6220007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.6216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.252876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.2517172636 2563599 1399818 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2512151625
MESH:D055370 Lung Injury Lipopolysaccharides 3.8621114838
MESH:D008175 Lung Neoplasms Asbestos 2.7312111688
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.7311884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3616002989
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.8512929590 14578162
MESH:D008569 Memory Disorders sevoflurane 4.6019212262
MESH:D008654 Mesothelioma Asbestos 4.0316919927 16319530 18310086 16564556 18709470
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.7218186108
MESH:D009203 Myocardial Infarction Genistein 5.4717141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.0017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3217484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.8418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.8418551238 7678174
MESH:D009369 Neoplasms Diethylstilbestrol 4.7915313581
MESH:D009369 Neoplasms pirinixic acid 4.7917405874
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.5811399458
MESH:D009421 Nervous System Malformations Genistein 15.5816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5814600291
MESH:D009436 Neural Tube Defects sodium arsenate 3.8610525206 11749123 18186108 19446573
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.4412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.4416049721
MESH:D010018 Osteomalacia Phenobarbital 4.2117016548
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9416169203
MESH:D010051 Ovarian Neoplasms Genistein 2.5519005980
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4416965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5215687265 16977796
MESH:D011014 Pneumonia Lipopolysaccharides 4.4012224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.492563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.0617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0611896295 11118676 11399792 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6315572423
MESH:D011471 Prostatic Neoplasms Calcitriol 2.7316289102 15754350 18247401 12479363 16644109
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.7317136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Genistein 2.7316925846 15256057 15378649
MESH:D019310 Pseudolymphoma Phenobarbital 4.3412752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6310835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012640 Seizures 2,4-dinitrotoluene 9.2118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.2118551238
MESH:D012640 Seizures Phenobarbital 9.213137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.676407741
MESH:D012871 Skin Diseases monomethylarsonous acid 3.3417431481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.5616709447 16002989
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0315821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.941399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.5016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.5016049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.5016712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 11.5020375083
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 20.1910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 20.1910091137
MESH:D014571 Urologic Neoplasms M-VAC protocol 20.1917933135
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.9016175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.9216690809 15809267
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2916513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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