AutismKB 2.0

Annotation Detail for DCLRE1A


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Basic Information Top
Gene Symbol:DCLRE1A ( KIAA0086,PSO2,SNM1,SNM1A )
Gene Full Name: DNA cross-link repair 1A
Band: 10q25.3
Quick LinksEntrez ID:9937; OMIM: 609682; Uniprot ID:DCR1A_HUMAN; ENSEMBL ID: ENSG00000198924; HGNC ID: 17660
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DCLRE1A mRNAaffects expression 17562736
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCLRE1A mRNAaffects cotreatment|increases expression 17942748
C051890 irinotecan irinotecan metabolite results in decreased expression of DCLRE1A mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of DCLRE1A mRNAdecreases expression 15956246
D010634 Phenobarbital Phenobarbital results in increased expression of DCLRE1A mRNAincreases expression 19270015
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCLRE1A mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.156195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.1515322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.9517620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.9516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0120007298 17173139 20935162 6705139 1701930
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1316105132 17681005 11677210 16919318 17110522 17333356 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.228697196 12621046 15340226 16354765 15668235
MESH:D003110 Colonic Neoplasms irinotecan 2.6417725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3617454858 18259882 15273666 16391804 18509181 16303861 17159606
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8316109766 11739529 19416960 14550746 18071297 11529661 19370779 12540782 19085960 17906064 16177239 11743745 11461765 19164858 11287661 10663392 12705907 15619225 16781746 2444490 19739265 19923254 15968718 18713872 11834606 10774834 12958197 19420014 10915739 12594235 14725611 12153990 16227642 14986274 17562736 11421492 12392966 16393943 17522070 16485898 16081117
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.4811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4911294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Phenobarbital 10.1016109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.1012621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.668697196 15340226 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 4.1719014921 11587558 19460945 16611625 12969438 16610002 19784758 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.7919812893 15975961 19482888 8742319 19073162 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7916984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.4817172636 18308698 1399818 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D052016 Mucositis irinotecan 5.5517159606
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009362 Neoplasm Metastasis irinotecan 3.2818259882
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009447 Neuroblastoma irinotecan 3.648761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D017599 Neuroectodermal Tumors irinotecan 5.278761367
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311222880 11118676 11399792 11896295
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012640 Seizures Phenobarbital 2.9211442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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