AutismKB 2.0

Annotation Detail for CDC25B


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Basic Information Top
Gene Symbol:CDC25B ( - )
Gene Full Name: cell division cycle 25 homolog B (S. pombe)
Band: 20p13
Quick LinksEntrez ID:994; OMIM: 116949; Uniprot ID:MPIP2_HUMAN; ENSEMBL ID: ENSG00000101224; HGNC ID: 1726
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04010MAPK signaling pathway
hsa04110Cell cycle
Pathway IDPathway Name
Cell Cycle, Mitotic
Pathway IDPathway Name
200135p38 signaling mediated by MAPKAP kinases
200120FOXM1 transcription factor network
200087PLK1 signaling events
200166Aurora A signaling
No data
Pathway IDPathway Name
500991Cyclin A/B1 associated events during G2/M transition
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C446520 2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone 2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone results in decreased expression of CDC25Bdecreases expression 16077967
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CDC25B mRNAincreases expression 19031421
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CDC25B mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CDC25B proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDC25B mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of CDC25B mRNAdecreases expression 18929588
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC25B mRNAdecreases expression 20382639
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of CDC25B mRNAdecreases expression 17553608
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CDC25B mRNAdecreases expression 15336504
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of CDC25B mRNAaffects cotreatment|increases expression 18636392
C012843 cinnamic aldehyde cinnamic aldehyde analog results in decreased activity of CDC25B proteindecreases activity 16343908
D016572 Cyclosporine Cyclosporine results in decreased expression of CDC25B mRNAdecreases expression 20106945
D004052 Diethylnitrosamine AHR protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC25B mRNA]decreases reaction|increases expression 19996281
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CDC25B mRNAincreases expression 19996281
C007610 equol equol results in decreased expression of CDC25B mRNAdecreases expression 16865672
D004958 Estradiol Estradiol results in increased expression of CDC25B proteinincreases expression 20208560
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of CDC25B protein]decreases reaction|increases expression 20208560
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25B protein]decreases reaction|increases expression 20208560
D005472 Fluorouracil Fluorouracil results in decreased expression of CDC25B mRNAdecreases expression 16709241
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of CDC25B protein]decreases reaction|increases expression 20208560
D019833 Genistein Genistein results in decreased expression of CDC25B mRNAdecreases expression 16865672
D005978 Glutathione [CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenateaffects cotreatment|increases reduction 20025242
C051890 irinotecan irinotecan metabolite results in decreased expression of CDC25B mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of CDC25B mRNAdecreases expression 15956246
C020300 monomethylarsonic acid monomethylarsonic acid results in decreased activity of CDC25B proteindecreases activity 20025242
D009151 Mustard Gas Mustard Gas results in increased expression of CDC25B mRNAincreases expression 15674843
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of CDC25B mRNAdecreases expression 15585362
D009532 Nickel Nickel results in increased expression of CDC25B mRNAincreases expression 19031421
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of CDC25B mRNAaffects cotreatment|increases expression 18636392
D010126 Ozone Ozone results in increased expression of CDC25B mRNAincreases expression 16330353
C025299 polyphenols polyphenols results in decreased expression of CDC25B mRNAdecreases expression 16293270
C487081 PXD101 PXD101 results in decreased expression of CDC25B mRNAdecreases expression 19606018
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of CDC25B mRNAdecreases expression 16678137
C009277 sodium arsenate [CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenateaffects cotreatment|increases reduction 20025242
C009277 sodium arsenate sodium arsenate results in decreased activity of CDC25B proteindecreases activity 20025242
C017947 sodium arsenite sodium arsenite results in decreased activity of CDC25B proteindecreases activity 20025242
C017947 sodium arsenite sodium arsenite results in decreased expression of CDC25B mRNAdecreases expression 12377979
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25B protein]decreases reaction|increases expression 20208560
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CDC25B mRNAincreases expression 17101203
19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CDC25B mRNAdecreases expression 19684285
D013750 Tetrachloroethylene Tetrachloroethylene results in increased expression of CDC25B mRNAincreases expression 19031421
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of CDC25B mRNAincreases expression 19031421
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of CDC25B mRNAdecreases expression 15289447
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of CDC25B mRNAdecreases expression 17951470
C012589 trichostatin A trichostatin A results in decreased expression of CDC25B mRNAdecreases expression 19606018
D014810 Vitamin E Vitamin E results in increased expression of CDC25B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.1718287403
MESH:D055371 Acute Lung Injury Chlorine 8.4920601635
MESH:D055371 Acute Lung Injury Nickel 8.4916166738
MESH:D000230 Adenocarcinoma Estradiol 6.4911473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.4917638652
MESH:D000230 Adenocarcinoma Genistein 6.4911473722
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.1315814487
MESH:D000236 Adenoma Diethylnitrosamine 2.6210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.7416434500 17620307 18056438 19052882 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5017306315 16712894
MESH:D000544 Alzheimer Disease Ozone 2.3515513908
MESH:D000740 Anemia Fluorouracil 7.5515504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5511748828
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6515570426
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 4.6519898480
MESH:D001249 Asthma Mustard Gas 4.6410378619
MESH:D001249 Asthma Ozone 4.6417854713 16373670
MESH:D001284 Atrophy fulvestrant 4.4711514358
MESH:D001321 Autistic Disorder Glutathione 3.0619056591 16917939 19267885 18929414
MESH:D001768 Blister Mustard Gas 4.7619167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.6912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.5117474063
MESH:D001943 Breast Neoplasms equol 6.5116898868
MESH:D001943 Breast Neoplasms Estradiol 6.5117261762 18497071 19861407 17018787 17289903 14630087 12948864 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 6.5119217205 16110121 15136595 16595493 18357371 16557594 18608205
MESH:D001943 Breast Neoplasms fulvestrant 6.5118984771
MESH:D001943 Breast Neoplasms Genistein 6.5117200150 16873071 16541309
MESH:D001943 Breast Neoplasms Nickel 6.5115986119
MESH:D001943 Breast Neoplasms Tamoxifen 6.5118855134 17261762 18351453 18984771 18629630 19288272 19221464 19410462 18815881 15668708 17893378 17440819 19011961 19289846 16202921 19103187 19084267 20390343 19142967 16873071 19189210 17049068 19189212 19115204 18997820 21152245 19244106 19200415 16818667 20005174 19059307 20544844 20065188 21138602 19155303 18425577 11161223 15565566 20135344 19487384 19066611 20859285 16273361 18821012 17242785
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.5120435547
MESH:D001943 Breast Neoplasms Tetrachloroethylene 6.5115986119
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3718315731 16777450 18417511 15516495 14754758 19059883 17626835
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5817687719 10378619
MESH:D002100 Cachexia Ozone 4.3516183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.5516050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2716051944
MESH:D002277 Carcinoma Fluorouracil 7.1617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1219066611
MESH:D006528 Carcinoma, Hepatocellular 2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone 18.4116096431
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.4116705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 18.4112907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.4117055752 16540662 19208518 17162532 16935385 20935162 19052882 16830150 10672840 20101231 19107877 16698587 20432363 19519916 18056438 19394651 20514400 20084675 17761372 18785209 16328049 18978308 20214788 16807293 19418558 20524982 18691550 11831363 18393292 17428255 20727157 19171122 3084413 17978847 18971187 19335982 18210153 17138121 19919837 21159647 16569478 19822196 16878318 19701751 10737359 17173139 20512989 3581430 18665156 20007298 16502159 16779866 18494052 18506893 19383236 19539802 18788625 16288022 16681979
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.4116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 18.4116332177 17971768 17045692 17088986 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 18.4116924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.4117306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 18.4116924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.2811212258
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 13.0118986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Glutathione 13.0117015178
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.0118572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 13.0118922899
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 13.0111212258
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.0316332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 27.626135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 27.6220889678
MESH:D002471 Cell Transformation, Neoplastic cinnamic aldehyde 27.628243401
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 27.6212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 27.6221159647 7505956 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 27.6218566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 27.6219524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.2319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2316835633
MESH:D002779 Cholestasis Cyclosporine 2.6319486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9315340226 12621046 8697196 16354765 15668235
MESH:D003110 Colonic Neoplasms arsenite 12.9815037631
MESH:D003110 Colonic Neoplasms cinnamic aldehyde 12.9817510524 16343908
MESH:D003110 Colonic Neoplasms Fluorouracil 12.9817725105 17172411 15001691 17169374 16510598 17287894 17018589 17016597 18772588 16340194
MESH:D003110 Colonic Neoplasms Genistein 12.9817182828
MESH:D003110 Colonic Neoplasms irinotecan 12.9817287894 17725105
MESH:D003110 Colonic Neoplasms polyphenols 12.9816293270
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6217401013 18383874 14970324 20501625 16331619 18802399 15148649 16524972 17454858 16282729 17094418 18509181 17255274 16303861 17016601 17695437 15289873 18288408 18949393 18448328 16391804 17594712
MESH:D015179 Colorectal Neoplasms irinotecan 2.6217159606 17454858 18259882 18509181 16391804 16303861 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7317141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.6010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.6019769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.6318551238
MESH:D003550 Cystic Fibrosis Glutathione 4.1519747007
MESH:D007644 Darier Disease Fluorouracil 4.4016733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9819031437
MESH:D017449 Dermatitis, Allergic Contact cinnamic aldehyde 6.6411042091
MESH:D017449 Dermatitis, Allergic Contact Nickel 6.6417100760 17244072 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.282952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.4620387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.4616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.4617107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.7419279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.7419279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 10.6421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 10.6419107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 10.6419370779
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 10.6418186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.6420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4711462148
MESH:D004417 Dyspnea Chlorine 4.2320016425
MESH:C538011 Eales disease Vitamin E 4.309068938
MESH:D004487 Edema Mustard Gas 9.5711428631 11402378 9260866 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.5711000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 9.5711698051 9599246 7812673 8273558 8113982 15177302 16716910
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5016714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.1719031437
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.2419294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.1916402032
MESH:D016889 Endometrial Neoplasms Estradiol 10.9511473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 10.9511473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.9520544844 19155303 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.689294722 10568697
MESH:D004890 Erythema Mustard Gas 4.769357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7116302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1320426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.1316337965 16785472 15173087 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7211564622
MESH:D005234 Fatty Liver arsenite 15.9218296743
MESH:D005234 Fatty Liver Cyclosporine 15.9219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 15.9221071580 20387270
MESH:D005234 Fatty Liver Tamoxifen 15.9214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7919069698
MESH:D005355 Fibrosis arsenite 12.5718296743
MESH:D005355 Fibrosis Cyclosporine 12.5712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.5720067830
MESH:D005739 Gas Poisoning Chlorine 4.6120016425
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.828708960
MESH:D005909 Glioblastoma Genistein 6.6516598420
MESH:D005909 Glioblastoma trichostatin A 6.6518801729
MESH:D005910 Glioma Fluorouracil 2.7116145905
MESH:D018149 Glucose Intolerance sodium arsenate 4.7219446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1218337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 5.8516080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D015658 HIV Infections Nickel 3.6117263646
MESH:D006689 Hodgkin Disease sodium arsenite 2.8312676792
MESH:D019584 Hot Flashes Estradiol 8.7117088409
MESH:D019584 Hot Flashes Vitamin E 8.7114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.648697196 18606429 15340226 16959395 16354765
MESH:D006973 Hypertension Cyclosporine 4.4110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4118670907 18850075
MESH:D007248 Infertility, Male fulvestrant 6.2311514358
MESH:D007248 Infertility, Male sodium arsenite 6.2312646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 24.9118785209
MESH:D007249 Inflammation Mustard Gas 24.9111428620 11428647 11428631 16001271 9260866 11402378 8975870 9357497 17524151
MESH:D007249 Inflammation Nickel 24.9116166738
MESH:D007249 Inflammation polyphenols 24.9116366677
MESH:D007249 Inflammation Tamoxifen 24.9119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 24.9112200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 24.9115177302 11698051 8273558 7562506 7812673
MESH:D007249 Inflammation Tobacco Smoke Pollution 24.9118590791
MESH:D007251 Influenza, Human Vitamin E 3.8116624496
MESH:D007333 Insulin Resistance Estradiol 2.7116627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0415604871
MESH:D007674 Kidney Diseases Cyclosporine 12.538314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 12.5315618244
MESH:D007674 Kidney Diseases sodium arsenite 12.5320008137
MESH:D007674 Kidney Diseases Vitamin E 12.5312488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 19.9512371664
MESH:D007680 Kidney Neoplasms Estradiol 19.9515610895
MESH:D007680 Kidney Neoplasms Fluorouracil 19.9516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 19.9518625569
MESH:D007938 Leukemia Genistein 2.8217468513 18980019
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 2.8318206229
MESH:D008064 Lipidoses Tamoxifen 2.8715342952 17567588
MESH:D008103 Liver Cirrhosis arsenite 6.0918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.0919638242 18407596 18522880 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.1217823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.1218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.1216169303
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1717034775
MESH:D008107 Liver Diseases polyphenols 6.1716698588
MESH:D008107 Liver Diseases Tetrachloroethylene 6.1717267091
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.417678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 19.419163691 2125692 15890375 18177683
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.4119256749 19850985 19255062 19090486 18978307 15885732 19996281 15175105 20583210 18648771 20492335 19812893 10737359 18977376 20405173 20452335 20501860 19551842 2862719 18644402 21167192 20434301 21071580 20118626 19642983 2422723 9163691 19254457 19426721 18754104 16942905 19294768 19499222 20101389 19833225 19638242 19690152 12112319 21047994 21278145 20137499 12771043 19427195 19073162
MESH:D008113 Liver Neoplasms Fluorouracil 19.4116603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms sodium arsenite 19.4116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 19.4116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.4116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.016135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.018603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.0119519916 16267830 18282651 2563599 17942915 19539802 18093689 19009564 9362446 17174075 16842330 17854601 18253720 18079962 18164116 18775883 18308698 18544905 3124819 19004024 19126423 21159647
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.0112151625
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 16.017955063
MESH:D008171 Lung Diseases Mustard Gas 15.4118702808 18161513
MESH:D008171 Lung Diseases Ozone 15.4119066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 15.4119095001
MESH:D008171 Lung Diseases Vitamin E 15.4116863852
MESH:D055370 Lung Injury Ozone 3.4720417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 21.7914755239
MESH:D008175 Lung Neoplasms arsenite 21.7916809336
MESH:D008175 Lung Neoplasms Diethylnitrosamine 21.7920970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 21.7915246190
MESH:D008175 Lung Neoplasms Mustard Gas 21.798781369 3148597
MESH:D008175 Lung Neoplasms Ozone 21.797614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 21.7915276417 16712894 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 21.7918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 21.7911884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 21.7911807781
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 21.7916288123 3440675 11091918 12111688
MESH:D008175 Lung Neoplasms Vitamin E 21.7911062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4015086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.1917203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.1914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.1916827153 11731420 19196723 14580682 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 12.198985016
MESH:D020149 Manganese Poisoning Estradiol 11.3119453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.3119453300
MESH:D008545 Melanoma sodium arsenite 4.7419082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.7412393984 19393235
MESH:D008545 Melanoma trichostatin A 4.7416505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7915990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3916801185
MESH:D008679 Metaplasia Ozone 4.7010496685
MESH:D009062 Mouth Neoplasms Fluorouracil 7.9618986760 16757204
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 7.9615006635
MESH:D052016 Mucositis irinotecan 4.6117159606
MESH:D009101 Multiple Myeloma trichostatin A 3.5918172295
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.5018186108
MESH:D009203 Myocardial Infarction Genistein 2.6917141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.5117141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.4718551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.579029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 8.5718259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3819410462
MESH:D009369 Neoplasms Fluorouracil 7.3616928823 18239605 18600527
MESH:D009369 Neoplasms sodium arsenite 7.3611559025
MESH:D009369 Neoplasms Tetrachloroethylene 7.3611911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2920056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6019189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 8.8415738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.8417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9519348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 14.2011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 14.2016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.2014600291
MESH:D009436 Neural Tube Defects sodium arsenate 6.7811749123 10525206 19446573 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 6.7812854658
MESH:D009447 Neuroblastoma irinotecan 3.278761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0220387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.348761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7120387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1716436463
MESH:D009503 Neutropenia Mustard Gas 3.6116761898 7688884
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.0916049721
MESH:D010024 Osteoporosis Genistein 3.0119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7216169203
MESH:D010051 Ovarian Neoplasms Estradiol 10.2019401270
MESH:D010051 Ovarian Neoplasms Genistein 10.2019005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.2015276417 17306315
MESH:D010051 Ovarian Neoplasms trichostatin A 10.2019331143
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.1416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.1416500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 11.1415976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 11.1419294695
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.918330346 12065085 18404319 18922899
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010538 Peritonitis Ozone 3.7516369182
MESH:D011014 Pneumonia Ozone 4.0018007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.4415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.8512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.852563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8011118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis trichostatin A 4.8717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5320887781
MESH:D011471 Prostatic Neoplasms equol 2.3516898868 16925846
MESH:D011471 Prostatic Neoplasms Estradiol 2.3516740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.3519082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.3515378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3516039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3515067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.3519789329 18798265
MESH:D011471 Prostatic Neoplasms Vitamin E 2.3515084515
MESH:D011537 Pruritus Mustard Gas 3.7018058305
MESH:D011565 Psoriasis Cyclosporine 2.0816882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7717894541 10334151 17720292 17266442 17620002
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6818286688 15538739 16160472 18722050
MESH:D012120 Respiration Disorders Chlorine 4.8118579056
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.2418410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.2818551238
MESH:D012871 Skin Diseases monomethylarsonic acid 7.5021378128
MESH:D012871 Skin Diseases Mustard Gas 7.5012880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin E 7.5018709164
MESH:D012878 Skin Neoplasms sodium arsenite 15.8818572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.888532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.8816192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 15.888330346 12065085 18404319 8985016 11807781
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 15.8818590791
MESH:D013088 Spermatocele Tamoxifen 3.8916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4912854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2218456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2215786421 18396642 16951190 17522103 17498489 16424979 19084572 18567086 19015929 17172411
MESH:D013274 Stomach Neoplasms irinotecan 3.2215723263
MESH:D020521 Stroke Vitamin E 3.2116517955
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.8517997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.697505956
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6516280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.6016049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.6016452187 16712894 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.6017572228 16712894 8653321
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 10.6012846360
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9210091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.3516803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.3511813266
MESH:D014605 Uveitis Cyclosporine 3.581336536
MESH:D014652 Vascular Diseases sodium arsenite 4.0317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0417120751
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:152 Cell Cycle, Mitotic
KEGG:04010 MAPK signaling pathway
KEGG:04914 Progesterone-mediated oocyte maturation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26260
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA449957ibuprofen
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01769 - Double Oxidized Cysteine
    DB03131 - Beta-Mercaptoethanol
    DB03398 - Cysteine Sulfenic Acid
    DB03661 - Cysteinesulfonic Acid
    DB03674 - Methyl Mercury Ion
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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