AutismKB 2.0

Annotation Detail for HS3ST3B1


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Basic Information Top
Gene Symbol:HS3ST3B1 ( 30ST3B1,3OST3B1 )
Gene Full Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
Band: 17p12
Quick LinksEntrez ID:9953; OMIM: 604058; Uniprot ID:HS3SB_HUMAN; ENSEMBL ID: ENSG00000125430; HGNC ID: 5198
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6564heparan sulfate biosynthesis
PWY-6558heparan sulfate biosynthesis (late stages)
Pathway IDPathway Name
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate
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Related Diseases/Disorders Top
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Desease Name
protein quantitative trait loci
Desease Name
Protein quantitative trait loci
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HS3ST3B1 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HS3ST3B1 mRNAaffects expression 17484886
C051890 irinotecan irinotecan analog results in increased expression of HS3ST3B1 mRNAincreases expression 18927307
C017947 sodium arsenite sodium arsenite results in increased expression of HS3ST3B1 mRNAincreases expression 17879257
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of HS3ST3B1 mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HS3ST3B1 mRNAdecreases expression 17949056
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5117306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616192424 16227642 16050911 15721981 16011737 15673190 16097048 15700767 16124888 10355542 18705752 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2018788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.2017306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5220889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.5219524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms irinotecan 2.6417725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3615273666 17159606 16303861 18259882 18509181 16391804 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0019085960 19336974 16227642 3732212 16177239 3786805 9327722 6623471 21278145 15998439 17522070 7179309 10915739 11566570 2869522 7120509 4309450 6884620 7440962 15027814 15968718 10092053
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5415959796 61145 12795759 16239168 12631006 17595544 16045604 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.2618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.2620067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.4712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6616959395 8697196 18606429 15340226 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007248 Infertility, Male sodium arsenite 3.2115346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases sodium arsenite 2.9820008137
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9816943688 11408273 11903743 17174718 17334410 16221502 21278145 16239168 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3715123356 17869086 18279442 15673190 12741479 12666154 18205269 18006644 15996030 18472094 18339082 14748882 12586293 17708605 10355542 15338365 15362042 15931870 17721639 17557913 16027843 18054572 18481824 18472332 17565644 18412020 14716833 14512876 18263696 12632514 18705752 16136751 18429990 15730626 15959796 14716496 11481614 18376398 17976157 17481882 18156304 17761835 17525996 16248980 14724832 17698563 12632512 12898905 12667390 12389079 18187930 17714472 18420326 12445418 18418968 15925388 12609069 16638106 18395095 18251166 13678700 18210741 18317297 17823541 15876570 15818738 16116963 17922224 17631135 15370692 16011737 16015684 17640975 17805973 12445421 12546737 20821823 12649538 16097048 18395914 15057751 18277467 17900296 14620537 15650968 16033810 18166357 15893842 16192424 15052691 12958196 17944888 17766677
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1515720792 15830285 16964402 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0619294768
MESH:D008113 Liver Neoplasms sodium arsenite 8.0615276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0616984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4512151625
MESH:D008171 Lung Diseases sodium arsenite 3.4019095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3816712894 19931552 15276417 17077188 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3819555203 11884234
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D052016 Mucositis irinotecan 5.5517159606
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009362 Neoplasm Metastasis irinotecan 3.2818259882
MESH:D009369 Neoplasms sodium arsenite 2.6411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3612854658
MESH:D009447 Neuroblastoma irinotecan 3.648761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.278761367
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5217306315 15276417
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms sodium arsenite 6.0718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0716192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6217306315 16452187 16712894 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1111813266
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
Pathway ID Pathway Name
KEGG:00534 Glycosaminoglycan biosynthesis - heparan sulfate
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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