AutismKB 2.0

Annotation Detail for HS3ST1


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Basic Information Top
Gene Symbol:HS3ST1 ( 3OST,3OST1 )
Gene Full Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Band: 4p15.33
Quick LinksEntrez ID:9957; OMIM: 603244; Uniprot ID:HS3S1_HUMAN; ENSEMBL ID: ENSG00000002587; HGNC ID: 5194
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6564heparan sulfate biosynthesis
PWY-6558heparan sulfate biosynthesis (late stages)
Pathway IDPathway Name
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of HS3ST1 mRNAincreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HS3ST1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HS3ST1 mRNAdecreases expression 20064835
D003345 Corticosterone Corticosterone results in increased expression of HS3ST1 mRNAincreases expression 15755911
C014347 decitabine decitabine results in increased expression of HS3ST1 mRNAincreases expression 15251184
C014347 decitabine [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of HS3ST1 mRNAaffects cotreatment|increases expression 15251184
D004281 Docosahexaenoic Acids PPARA protein promotes the reaction [Docosahexaenoic Acids results in increased expression of HS3ST1 mRNA]increases expression|increases reaction 18489776
D004317 Doxorubicin HS3ST1 mRNA affects the susceptibility to Doxorubicinaffects response to substance 16044152
D015118 Eicosapentaenoic Acid PPARA protein promotes the reaction [Eicosapentaenoic Acid results in increased expression of HS3ST1 mRNA]increases expression|increases reaction 18489776
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in increased expression of HS3ST1 mRNAincreases expression 16823509
D043371 Fatty Acids, Omega-6 Fatty Acids, Omega-6 results in increased expression of HS3ST1 mRNAincreases expression 16823509
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of HS3ST1 mRNAaffects cotreatment|increases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HS3ST1 mRNAincreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HS3ST1 mRNAincreases expression 19490992
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of HS3ST1 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5420127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 4.5417418594
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000419 Albuminuria Doxorubicin 4.6721441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 9.5118448859
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-6 9.5118448859
MESH:D001321 Autistic Disorder Docosahexaenoic Acids 3.0518582451
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 3.0516920077
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8714601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.9117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9720146248 17474063
MESH:D001943 Breast Neoplasms decitabine 1.9719208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 1.9716264153 18382427 19526202 15993339 16096432 17426702 15939500 15567936 15136595 16935488 18695136 15634643 18628466 16322301 16595493 15668708 17369602 15994142 11325840 15692762 16115903 18234424 17983394 16826403
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2418059187 16023760 17876044 16234567
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.201485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7620419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.7619215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.766189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.6017924179 17329180 17974986 17131338 16455267 17519947 15811867 17308081 17928571 17351982 17382496 16269455 16242529 15476868 16278810 16364871 16612575 16651473 15792986 18627295 16952015 16109756 17007740 15505089 16731534
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9816243910 17334414
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.148697196 15340226 15668235 12621046 16354765
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.7118981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7118802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003550 Cystic Fibrosis Docosahexaenoic Acids 4.7719747007
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.4616684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 3.9717416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9720420201
MESH:D004362 Drug Toxicity Doxorubicin 8.3818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3811462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2919294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5217359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3318037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005909 Glioblastoma Doxorubicin 3.4217150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms decitabine 8.2019215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.2015692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6310048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.5616244371 16879835 16330681 18006777 17888722 16495754 18674790 16244372 16707910 14766674 16144979 17875725 12587719
MESH:D006333 Heart Failure Doxorubicin 3.4117481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0115692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 12621046 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.5017606976 18501091 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216959395 15340226 18606429 8697196 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007248 Infertility, Male decitabine 3.2717581917
MESH:D007249 Inflammation Fatty Acids, Omega-3 5.6617296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6612878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Doxorubicin 3.1115369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2616707910
MESH:D007938 Leukemia decitabine 3.1219235587 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3316085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Docosahexaenoic Acids 5.1117077332
MESH:D007951 Leukemia, Myeloid decitabine 4.1118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918704418 18460780 19387464 19010910 18206229 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.4616595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4612878042
MESH:D008107 Liver Diseases Docosahexaenoic Acids 3.4317056761
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4520195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4516984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.1316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4617053015 18569708 18520028 20464547 6695378 20064080 20135361 18816296 20869020
MESH:D008175 Lung Neoplasms Doxorubicin 3.4617418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4611884234 19555203
MESH:D008223 Lymphoma decitabine 7.9919470736
MESH:D008223 Lymphoma Doxorubicin 7.9916098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7015621674
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 6.7412807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.7415458769
MESH:D008545 Melanoma decitabine 3.6016505122 17785578
MESH:D008545 Melanoma Doxorubicin 3.6016827129
MESH:D008654 Mesothelioma Doxorubicin 3.1017638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6115792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D052016 Mucositis Doxorubicin 4.9417415656
MESH:D009101 Multiple Myeloma decitabine 3.4218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4419010910 16882708 18608210 19157545
MESH:D009203 Myocardial Infarction Doxorubicin 2.9919429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9918259882
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2711141357
MESH:D009369 Neoplasms decitabine 5.2717925555 19116145 19470736
MESH:D009401 Nephrosis Doxorubicin 4.9116636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1015640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009447 Neuroblastoma Doxorubicin 3.3115555623
MESH:D012516 Osteosarcoma Doxorubicin 4.2015930896
MESH:D010051 Ovarian Neoplasms decitabine 2.6819331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.8019294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.8717616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2517292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.2516888761 15897917 16868541 16729912 15749863 18437689
MESH:D051437 Renal Insufficiency Doxorubicin 4.3617922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5219155313
MESH:D012509 Sarcoma Doxorubicin 4.0917203757 16767912 15675481 15625365 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3716326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9417846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7119755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 9.7115692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7015625365 17203757 16767912
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.6020155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 3.6019037991
MESH:D013274 Stomach Neoplasms Docosahexaenoic Acids 3.6019015929
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms decitabine 7.7017967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.7016010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6217053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.6217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.6217653716
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3617334414 16364871 17678736 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
KEGG:00534 Glycosaminoglycan biosynthesis - heparan sulfate
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01812 - Adenosine-3'-5'-Diphosphate
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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