AutismKB 2.0

Annotation Detail for USP15


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Basic Information Top
Gene Symbol:USP15 ( KIAA0529,MGC131982,MGC149838,MGC74854,UNPH4 )
Gene Full Name: ubiquitin specific peptidase 15
Band: 12q14.1
Quick LinksEntrez ID:9958; OMIM: 604731; Uniprot ID:UBP15_HUMAN; ENSEMBL ID: ENSG00000135655; HGNC ID: 12613
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of USP15 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of USP15 mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of USP15 mRNAdecreases expression 17942131
C014949 acetylhydrazine acetylhydrazine results in decreased expression of USP15 mRNAdecreases expression 15282401
D000643 Ammonium Chloride Ammonium Chloride affects the expression of USP15 mRNAaffects expression 16483693
D001241 Aspirin Aspirin results in increased expression of USP15 mRNAincreases expression 11906190
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of USP15 mRNAdecreases expression 17942131
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of USP15 mRNAdecreases expression 17942131
D016572 Cyclosporine Cyclosporine results in decreased expression of USP15 mRNAdecreases expression 17942131
D005419 Flavonoids Flavonoids results in increased expression of USP15 mRNAincreases expression 18035473
C056933 fumonisin B1 fumonisin B1 results in decreased expression of USP15 mRNAdecreases expression 16221962
D008345 Manganese Manganese results in decreased expression of USP15 mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of USP15 mRNAdecreases expression 17175027
D008767 Methylmercury Compounds Methylmercury Compounds results in decreased expression of USP15 mRNAdecreases expression 16966085
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of USP15 mRNAincreases expression 17616710
D010100 Oxygen Oxygen deficiency results in decreased expression of USP15 mRNAdecreases expression 17175027
D014635 Valproic Acid Valproic Acid results in increased expression of USP15 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.488875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9119490988
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury Oxygen 4.5116759491
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9820464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.563712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.566695378
MESH:D000550 Amblyopia Valproic Acid 5.2317688650
MESH:D000756 Anemia, Sideroblastic Manganese 10.9716910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.9716910769
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D000860 Anoxia Oxygen 5.0520872349
MESH:D001008 Anxiety Disorders Valproic Acid 3.5517497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.6812372130 20485159
MESH:D050197 Atherosclerosis Oxygen 3.7916391483
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 18940202 18316065 18177632 20603192 18775368 17688650 19460635 17507914 18396377 17157402 18558336 19232924 18985861 16609825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0211289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.0617594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.398888407
MESH:D001932 Brain Neoplasms Aspirin 4.4015481559
MESH:D001943 Breast Neoplasms Aspirin 2.1415161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1420146248 17474063
MESH:D001943 Breast Neoplasms Oxygen 2.1417263869
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.4916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.493581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.493084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.667296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0420419170
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.066135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.067505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.0612371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7020734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.829022650 19486331
MESH:D002779 Cholestasis Cyclosporine 7.8219486331
MESH:D003110 Colonic Neoplasms Aspirin 2.9812411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.8917688650 8888407 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D003704 Dementia Methylmercury Compounds 4.9816140633
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.792524372 11298694 11906362 8970840 8156756 12868966 14531868 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.473621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.9718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.9716192314 6482804 7440962 9653073 18692083 8291058 18289764 9328219 9022650 6679447 1440618 18648102 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.9712153990 16485898 11739529 16393943 12540782 17906064 11461765 16109766 11529661 12705907 16781746 19923254 14725611 10915739 18713872 17522070 11743745 18071297 19416960 11834606 10663392 19370779 19739265 19420014 16177239 11421492 14550746 15968718 19085960 19164858 12594235 15619225 16227642 10774834 11287661 2444490 12392966 14986274 16081117 12958197 17562736
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 11.9716221962
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.971733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004417 Dyspnea Oxygen 4.8320016425
MESH:D004421 Dystonia Valproic Acid 4.031851702
MESH:D004487 Edema Aspirin 3.8717259670
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9216628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9218234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.576254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.287750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.063659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.253581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2516530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.2515547721 16510608 15547733 15264214 15878914 16704527 15150132 15623463 16805852
MESH:D005234 Fatty Liver Cyclosporine 7.7019224547
MESH:D005234 Fatty Liver Valproic Acid 7.7019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.8916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.118888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D005355 Fibrosis Cyclosporine 3.1312168785 12639820
MESH:D005739 Gas Poisoning Oxygen 5.2220016425
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D005909 Glioblastoma Aspirin 7.7512870263
MESH:D005909 Glioblastoma Manganese 7.7517043766
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006261 Headache Aspirin 4.9615240983
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6420471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.506705139
MESH:D006529 Hepatomegaly fumonisin B1 4.2616221962
MESH:D006849 Hydrocephalus Valproic Acid 4.8617688650
MESH:D012001 Hyperacusis Aspirin 5.7615240983
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Cyclosporine 2.0910903974
MESH:D007249 Inflammation Flavonoids 2.6417296493
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.028074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.7512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.7518776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.2616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.266582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2612371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1517596541 16294345
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1815034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6219014921 12969438 12587719 16611625 16610002 19784758 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.467678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4621137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.842876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.84598648 3712494 1399818 6587162
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2617228818
MESH:D055370 Lung Injury Oxygen 4.4918339021
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618816296 17053015 20135361 20464547 20869020 18520028 6695378 20064080 18569708
MESH:D020149 Manganese Poisoning Manganese 5.5219453300 16551646 16568477
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008569 Memory Disorders Methylmercury Compounds 4.8918436314
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D008881 Migraine Disorders Aspirin 7.8115240983
MESH:D008881 Migraine Disorders Valproic Acid 7.8118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009069 Movement Disorders Manganese 11.5616551646
MESH:D009069 Movement Disorders Methylmercury Compounds 11.5618436314
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.018888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1417596541
MESH:D009203 Myocardial Infarction Aspirin 3.5412692751
MESH:D009325 Nausea Aspirin 5.2115240983
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.857678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.463581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1611141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2718481113 19348381
MESH:D009410 Nerve Degeneration Manganese 4.2616551646
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.216679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.2116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.8216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.826482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010003 Osteoarthritis Aspirin 4.047009135
MESH:D010146 Pain Acetaminophen 6.8816870215
MESH:D010146 Pain Aspirin 6.886995502 6363464
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010300 Parkinson Disease Manganese 3.3611181820
MESH:D020734 Parkinsonian Disorders Manganese 4.4516140633
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.5311156591
MESH:D020795 Photophobia Aspirin 5.7615240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 10.0918436314
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.0920603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9817292933
MESH:D019310 Pseudolymphoma Valproic Acid 4.5411422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.4918339021 17627322
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.363692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1619155313
MESH:D012220 Rhinitis Aspirin 4.3512372130
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8918551238
MESH:D012640 Seizures Valproic Acid 5.893137016 16876388 11044598 1511512 15475178 14763951 11738929 17978042
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.2512269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3619755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5412833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.532093021 20155912
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.5312958204 17575124
MESH:D020521 Stroke Aspirin 4.3616403987
MESH:D013398 Sudden Infant Death Oxygen 5.5412563064
MESH:D013927 Thrombosis Aspirin 4.5017672075
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.871399818 6582329 7505956 6587162 3712494
MESH:D014178 Translocation, Genetic Valproic Acid 5.2317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.513119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.228074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2217053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.638888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 8.8410982225
MESH:D014581 Urticaria Aspirin 8.8410982225 20485159
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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