AutismKB 2.0

Annotation Detail for CDC27


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Basic Information Top
Gene Symbol:CDC27 ( ANAPC3,APC3,CDC27Hs,D0S1430E,D17S978E,HNUC )
Gene Full Name: cell division cycle 27 homolog (S. cerevisiae)
Band: 17q21.32
Quick LinksEntrez ID:996; OMIM: 116946; Uniprot ID:CDC27_HUMAN; ENSEMBL ID: ENSG00000004897; HGNC ID: 1728
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
hsa04114Oocyte meiosis
Pathway IDPathway Name
APC-Cdc20 mediated degradation of Nek2A
Cell Cycle, Mitotic
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cell Cycle Checkpoints
No data
No data
Pathway IDPathway Name
500391Regulation of APC/C activators between G1/S and early anaphase
500395Phosphorylation of the APC/C
500390APC/C-mediated degradation of cell cycle proteins
500401Autodegradation of Cdh1 by Cdh1:APC/C
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CDC27 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CDC27 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of CDC27 proteinincreases expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CDC27 mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC27 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of CDC27 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of CDC27 mRNAincreases expression 20106945
C006253 pirinixic acid pirinixic acid results in increased expression of CDC27 mRNAincreases expression 18301758
C059514 resveratrol resveratrol results in decreased expression of CDC27 mRNAdecreases expression 15767336
D014415 Tunicamycin Tunicamycin results in increased expression of CDC27 mRNAincreases expression 17127020
D014810 Vitamin E Vitamin E results in decreased expression of CDC27 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D058186 Acute Kidney Injury resveratrol 3.9916538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.066695378
MESH:D000236 Adenoma resveratrol 7.0615688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000544 Alzheimer Disease resveratrol 2.5916183991 16162502
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001169 Arthritis, Experimental resveratrol 3.5817115116
MESH:D050197 Atherosclerosis resveratrol 3.3516873680 17967414
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D002545 Brain Ischemia resveratrol 4.4817600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2517474063 20146248
MESH:D001943 Breast Neoplasms resveratrol 2.2517534123 17651959 16393696
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.7416227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7816675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8420419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.8416227395
MESH:D002318 Cardiovascular Diseases resveratrol 3.5715458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.696135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6912371664
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D003092 Colitis resveratrol 4.3016474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4716338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.8416507316
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8916873680
MESH:D003928 Diabetic Nephropathies resveratrol 4.0916286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9818551238 21346803
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema pirinixic acid 7.3712083418
MESH:D004487 Edema resveratrol 7.378985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.1917872969
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.0217923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0320131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.3212168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9220471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9216080930
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1719772884 18467677 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D006561 Herpes Simplex resveratrol 4.3716876885
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006937 Hypercholesterolemia resveratrol 4.1417188708
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006949 Hyperlipidemias resveratrol 4.1816873680
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4317488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.8217600658
MESH:D007249 Inflammation resveratrol 2.9116366677
MESH:D007251 Influenza, Human resveratrol 11.8316624496
MESH:D007251 Influenza, Human Vitamin E 11.8316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.278314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.2712488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.0616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0612371664
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6616087638
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4116169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.117678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1121137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 11.1115890375 20007298 16377806
MESH:D008113 Liver Neoplasms resveratrol 11.1119812893 20405173 19073162 19321006
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.626135515 2876784 2876786
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4618520028 18569708 20064080 20464547 20869020 18816296 17053015 20135361 6695378
MESH:D008175 Lung Neoplasms Vitamin E 2.4611062179
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4517088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4415688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.1911606380 8985016
MESH:D008545 Melanoma resveratrol 2.3817992120
MESH:D008659 Metabolic Diseases resveratrol 4.5217112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma resveratrol 3.5616490592 14749477 17049120 16267019 17935668 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.0617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.9119151258
MESH:D009203 Myocardial Infarction resveratrol 5.9117188708 16317513 17015251 16525036 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 4.1217125593 17015251
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009205 Myocarditis resveratrol 4.9517322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009374 Neoplasms, Experimental resveratrol 4.178985016
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D019636 Neurodegenerative Diseases resveratrol 3.9217652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5517929310
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4117513867
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.3716679765
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms resveratrol 2.5717675339 17636462 15767336 17804756 17718901 16731767
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5715084515
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.8016325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.7819058328
MESH:D015427 Reperfusion Injury resveratrol 6.7817058453 17520802 16317513 16314181 15827377
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8919755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 9.898985016 15837718
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.898532709
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Vitamin E 3.6316517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6116321402
MESH:D014062 Tongue Neoplasms resveratrol 4.3416227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5617053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2317473185
MESH:D014594 Uterine Neoplasms resveratrol 4.3017044934
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.4817488730
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
REACT:8017 APC-Cdc20 mediated degradation of Nek2A
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
KEGG:04110 Cell cycle
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
KEGG:04114 Oocyte meiosis
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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