AutismKB 2.0

Annotation Detail for USP3


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Basic Information Top
Gene Symbol:USP3 ( MGC129878,MGC129879,SIH003,UBP )
Gene Full Name: ubiquitin specific peptidase 3
Band: 15q22.3
Quick LinksEntrez ID:9960; OMIM: 604728; Uniprot ID:UBP3_HUMAN; ENSEMBL ID: ENSG00000140455; HGNC ID: 12626
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of USP3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of USP3 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of USP3 mRNAincreases expression 20458559
D001554 Benzene Benzene results in increased expression of USP3 mRNAincreases expression 15929907
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of USP3 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of USP3 mRNAincreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of USP3 proteinincreases expression 14561216
D008070 Lipopolysaccharides Lipopolysaccharides inhibits the reaction [USP3 protein binds to ALB promoter]affects binding|decreases reaction 14561216
D008070 Lipopolysaccharides Lipopolysaccharides inhibits the reaction [USP3 protein binds to GSTA2 promoter]affects binding|decreases reaction 14561216
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of USP3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of USP3 mRNAincreases expression 17426115
D012643 Selenium Selenium results in decreased expression of USP3 mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of USP3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.5511850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 9.5518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3111798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000741 Anemia, Aplastic Benzene 4.4817661222 14761424 11369114
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6217659584
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4719483382
MESH:D001855 Bone Marrow Diseases Benzene 5.4516183116
MESH:D001943 Breast Neoplasms Benzene 2.8811921183 17162533
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6411135700 16217749 15553829 14691202 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8712371664
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5115824018
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.5910525206
MESH:D019465 Craniofacial Abnormalities Benzene 5.5915643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.5917728286
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.5919769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003872 Dermatitis Benzene 4.9415902427
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.5812438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003967 Diarrhea Dexamethasone 3.867237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4211461765 19370779 19416960 2444490 10915739 16485898 18071297 19923254 16781746 15968718 11529661 18713872 14550746 11834606 14725611 17522070 17906064 19085960 12540782 19164858 11287661 19420014 19739265 16177239 12705907 10774834 17562736 14986274 16081117 10663392 11421492 15619225 16227642 12594235 12958197 16109766 16393943 11739529 12392966 12153990 11743745
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4215131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004485 Eczema Dexamethasone 4.6212438553
MESH:D004487 Edema Dexamethasone 7.3819703484
MESH:D004487 Edema pirinixic acid 7.3812083418
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5915821434 15328337 17637181
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5720426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5712903497
MESH:D005234 Fatty Liver arsenic trioxide 13.9015073043
MESH:D005234 Fatty Liver Cyclosporine 13.9019224547
MESH:D005234 Fatty Liver pirinixic acid 13.9020131406 19236843
MESH:D005334 Fever Lipopolysaccharides 4.149205823 11852909
MESH:D005355 Fibrosis Cyclosporine 3.3212168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0516080930
MESH:D006333 Heart Failure pirinixic acid 7.2220558911
MESH:D006333 Heart Failure Selenium 7.2217162251
MESH:D006402 Hematologic Diseases Benzene 4.8016183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5216366002
MESH:D006529 Hepatomegaly pirinixic acid 3.1719772884 18467677 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 6.127520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 6.1216863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Benzene 9.0317940673
MESH:D006973 Hypertension Cyclosporine 9.0310903974
MESH:D006973 Hypertension Dexamethasone 9.0317042910
MESH:D007249 Inflammation Dexamethasone 5.688960868 11099482
MESH:D007249 Inflammation Lipopolysaccharides 5.6817237260 12878042 17255318 9205823 17963957
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7817255318
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.4518776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.4512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D007938 Leukemia arsenic trioxide 6.7815070760
MESH:D007938 Leukemia Benzene 6.7818335105 15935818 17119257 14694614
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.1719077051
MESH:D007951 Leukemia, Myeloid Benzene 10.1717506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1816968895 20471514 17050201 19850784 16467208
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.1819478238
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3016966277 19642359 17869043 15336539 19225113 16331271 11161223 17217047 16823087 17107899 19075265 11468182 16891316 15748426 17649720 16112521 15213294 12712474 17712046 15622746 12679006 9834237 19035177 12018890 16330433
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.8915821434
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 5.1216718785
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.1212878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1215474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.1216169303
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 19014921 19784758 16610002 12969438 11587558 12587719 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 4.6314682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.6320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5220377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 6.5212562636
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D017563 Lung Diseases, Interstitial Benzene 5.0214698565
MESH:D055370 Lung Injury Lipopolysaccharides 4.1821114838
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0411798837 19825857
MESH:D008175 Lung Neoplasms Benzene 5.0412562636
MESH:D008175 Lung Neoplasms Dexamethasone 5.0411195469 15824018
MESH:D008175 Lung Neoplasms Vitamin E 5.0411062179
MESH:D008223 Lymphoma Benzene 3.8317119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.6412562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.5811921183
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.5815318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 12.8119417148 11468182 14977855 15949261 19549372
MESH:D009101 Multiple Myeloma Benzene 12.8117119195
MESH:D009101 Multiple Myeloma Dexamethasone 12.8115744524 15867202 16118317
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.8116882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.819809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8210525206
MESH:D009436 Neural Tube Defects Benzene 7.8215643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6016049721 12819281
MESH:D009784 Occupational Diseases Benzene 9.6015576619 17119257 17178637 15935809 15612468 16737584 15913788 17479406 15727169
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2319769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Benzene 5.2312562636
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5715580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.7512224865 11605937
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6221297632
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2719131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.1618379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8210835634
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D013272 Stomach Diseases Dexamethasone 4.5115472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7117007042
MESH:D013274 Stomach Neoplasms Benzene 2.7112562636
MESH:D013276 Stomach Ulcer Dexamethasone 3.6215138204
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3015821434
MESH:D013953 Thymus Neoplasms Benzene 5.1510850423
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2516049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2511780464 20435036 12845720 12973940
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Benzene 4.4912562636
MESH:D014605 Uveitis Cyclosporine 12.511336536
MESH:D014605 Uveitis Dexamethasone 12.511336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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