AutismKB 2.0

Annotation Detail for MVP


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Basic Information Top
Gene Symbol:MVP ( LRP,VAULT1 )
Gene Full Name: major vault protein
Band: 16p11.2
Quick LinksEntrez ID:9961; OMIM: 605088; Uniprot ID:MVP_HUMAN; ENSEMBL ID: ENSG00000013364; HGNC ID: 7531
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MVP mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MVP mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MVP mRNAaffects expression 16483693
D000970 Antineoplastic Agents MVP protein results in decreased susceptibility to Antineoplastic Agentsdecreases response to substance 11937269
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MVP mRNAincreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of MVP mRNAincreases expression 20826375
D002220 Carbamazepine Carbamazepine results in decreased expression of MVP mRNAdecreases expression 19632730
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of MVP mRNAaffects cotreatment|decreases expression 18636392
D016572 Cyclosporine Cyclosporine results in decreased expression of MVP mRNAdecreases expression 20106945
D003524 Cyclosporins Cyclosporins affects the activity of MVP proteinaffects activity 15788683
D004041 Dietary Fats Dietary Fats results in increased expression of MVP mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MVP mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of MVP mRNAincreases expression 19638242
D004317 Doxorubicin MVP protein affects the susceptibility to Doxorubicinaffects response to substance 17575109
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of MVP mRNAdecreases expression 18851785
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MVP mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MVP mRNAincreases expression 17557909
D005472 Fluorouracil Fluorouracil promotes the reaction [YBX1 protein binds to MVP promoter]affects binding|increases reaction 15750632
D005472 Fluorouracil Fluorouracil results in increased expression of MVP mRNAincreases expression 15750632
D005472 Fluorouracil Fluorouracil results in increased expression of MVP proteinincreases expression 15750632
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MVP mRNAaffects cotreatment|decreases expression 18544905
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of MVP mRNAaffects cotreatment|decreases expression 18636392
C041786 palm oil palm oil results in increased expression of MVP mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MVP mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MVP mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MVP mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of MVP mRNAincreases expression 18301758
D012643 Selenium Selenium results in increased expression of MVP mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MVP mRNAincreases expression 15716485
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MVP mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MVP mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of MVP mRNAincreases expression 18230668
C113580 U 0126 U 0126 results in decreased expression of MVP mRNAdecreases expression 15526378
C047426 venlafaxine venlafaxine results in decreased expression of MVP mRNAdecreases expression 16341940
C025643 vinclozolin vinclozolin affects the expression of MVP mRNAaffects expression 19015723
C088658 zoledronic acid zoledronic acid results in increased expression of MVP mRNAincreases expression 18225567
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 12.918986270
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.916195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.9115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.2317694057
MESH:D058186 Acute Kidney Injury zoledronic acid 4.2419715164
MESH:D055371 Acute Lung Injury Chlorine 8.3920601635
MESH:D055371 Acute Lung Injury pirinixic acid 8.3918653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.2320200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6420464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 9.6417418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6414692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.6417638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.166695378
MESH:D000236 Adenoma Diethylnitrosamine 6.1610737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.8216434500 17620307 17162532 19052882 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.8217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.8216835633
MESH:D000419 Albuminuria Doxorubicin 4.3121441931
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000544 Alzheimer Disease Ozone 2.3915513908
MESH:D000740 Anemia Fluorouracil 7.9717963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9711748828
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.1015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4615570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4616292516
MESH:D001249 Asthma epigallocatechin gallate 7.5916516891
MESH:D001249 Asthma Ozone 7.5916373670 17854713
MESH:D001249 Asthma Tretinoin 7.5916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.8219761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001714 Bipolar Disorder Carbamazepine 4.0120046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.9916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4514601052
MESH:D001859 Bone Neoplasms zoledronic acid 4.7315867366 11697798 17312309 16778634 19442620 16121404
MESH:D001862 Bone Resorption bisphenol A 9.0611985600
MESH:D001862 Bone Resorption zoledronic acid 9.0618496637 15845617 8053405 11869084 18404659 16769263
MESH:D001932 Brain Neoplasms Doxorubicin 3.6017150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.5820146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 5.5817123778
MESH:D001943 Breast Neoplasms Dietary Fats 5.5820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.5817474063
MESH:D001943 Breast Neoplasms Doxorubicin 5.5818628466 16595493 16115903 16826403 15939500 18234424 16264153 15993339 17369602 15692762 16096432 15634643 18695136 15668708 15136595 16935488 19526202 17426702 17983394 18382427 11325840 15567936 16322301 15994142
MESH:D001943 Breast Neoplasms Fluorouracil 5.5815136595 16595493 19217205 18357371 16110121 18608205 16557594
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5820435547
MESH:D001943 Breast Neoplasms Tretinoin 5.5816166294 16443354 16873071
MESH:D001943 Breast Neoplasms zoledronic acid 5.5816096432 18695136
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4918417511 19059883 15516495 14754758 18315731 17626835 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002100 Cachexia Ozone 4.4916183385
MESH:D002276 Carcinoid Tumor Doxorubicin 11.5216051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.5216051944
MESH:D002277 Carcinoma Fluorouracil 7.5517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.4416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.443084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.443581430 17055752 19519916 20514400 19052882 19919837 16698587 19539802 21159647 18788625 18971187 18506893 18210153 19208518 19822196 17173139 16779866 16569478 20084675 20214788 3084413 17761372 11831363 16502159 17162532 19171122 18665156 16328049 20101231 19701751 10737359 16288022 19418558 16878318 16540662 16935385 19335982 17978847 20512989 20727157 19107877 17138121 19383236 10672840 20935162 18393292 20007298 16681979 17428255 18691550 18494052 20432363 20524982 18056438 18785209 16830150 19394651 18978308 16807293
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.4418059187 16234567 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.4416799960 16332177 17971768 17088986 18930000 17045692
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.4417173139 6705139 1701930 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.441917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7417123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.4619233551
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.271485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.2718695887
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 10.2718507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.1920419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.196189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.1916757204 18986760 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.1916096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.3716731534 16651473 17924179 17007740 17974986 17329180 17928571 17131338 16278810 17308081 15792986 15505089 16612575 16109756 16269455 16364871 16455267 18627295 17382496 17351982 16952015 15476868 16242529 17519947 15811867
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8616243910 17334414
MESH:D002386 Cataract Acetaminophen 6.7510977129
MESH:D002386 Cataract Tretinoin 6.7517460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.0512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.0517174075 7505956 2727394 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D002779 Cholestasis Cyclosporine 12.3019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3016919318 16105132 17681005 17333356 17110522 15861022 11677210
MESH:D002779 Cholestasis pirinixic acid 12.3019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4216354765 12621046 15668235 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Selenium 8.6917936198
MESH:D003092 Colitis Tretinoin 8.6917035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1917287894 17725105 16340194 15001691 17172411 16510598 17169374 18772588 17018589 17016597
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.5918259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5918949393 18802399 17016601 16282729 18383874 17401013 14970324 20501625 17594712 16331619 18288408 16524972 17255274 17695437 17094418 16391804 15289873 15148649 18448328 16303861 17454858 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D019465 Craniofacial Abnormalities Carbamazepine 3.749014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.749664655 10589399 9142499 17551590 14991402 16925845 9224671 8800419 9125849 9211117
MESH:D003456 Cryptorchidism vinclozolin 4.1114966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7718551238
MESH:D007644 Darier Disease Fluorouracil 4.5416733453
MESH:D003866 Depressive Disorder venlafaxine 4.6520305041
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8420387270
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 6.8416988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8417107852
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.2011748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.2620216337 15057820 16538176 16538175
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.5218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.5212958197 15619225 16177239 19164858 14986274 16393943 16227642 16781746 11834606 17562736 16081117 18713872 10915739 12540782 19416960 10663392 18071297 14550746 11461765 11529661 11287661 19739265 15968718 19420014 12705907 11743745 19085960 2444490 16109766 16485898 11421492 19370779 17522070 19923254 17906064 12594235 10774834 11739529 12153990 12392966 14725611
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 17.5217465707
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.5219107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 17.5217416283
MESH:D056486 Drug-Induced Liver Injury Selenium 17.5215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.5220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Carbamazepine 12.8220216337
MESH:D004362 Drug Toxicity Doxorubicin 12.8218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.8211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2818367378
MESH:D004417 Dyspnea Chlorine 4.3820016425
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 8.6017654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6012538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.0617359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.0616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.819294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9118037988
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.0216538176 20485159 19915237 18855540 16415921
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 10.3817275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.383659116
MESH:D004828 Epilepsies, Partial Carbamazepine 9.5315008574 16628512 17116037
MESH:D004828 Epilepsies, Partial Phenobarbital 9.5311558140 3922381
MESH:D004827 Epilepsy Carbamazepine 6.6417178248 9014606 19439326 17465707 19700373 821787 19620853 20417680 18234410 7988514
MESH:D004827 Epilepsy Phenobarbital 6.6420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 10.887750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.887750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 10.053659116 15276670
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.053659116
MESH:D004916 Erythromelalgia Carbamazepine 5.4719549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2716530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.2715173087 17638652 16337965 16481741 16785472
MESH:D005076 Exanthema Carbamazepine 5.2220485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 22.2919224547
MESH:D005234 Fatty Liver Dietary Fats 22.2917967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 22.2920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.2915345470
MESH:D005234 Fatty Liver pirinixic acid 22.2920131406 19236843
MESH:D005264 Femoral Fractures zoledronic acid 5.5816234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3419069698
MESH:D005355 Fibrosis Cyclosporine 19.1412168785 12639820
MESH:D005355 Fibrosis Dietary Fats 19.1418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.1420067830
MESH:D005355 Fibrosis Tretinoin 19.1417994277
MESH:D005739 Gas Poisoning Chlorine 4.7620016425
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0516417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Doxorubicin 6.7217150277
MESH:D005909 Glioblastoma Tretinoin 6.7217312396
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.0315692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.0318337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.3420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.349664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.3217888722 16244372 16707910 14766674 18674790 16879835 18006777 12587719 16330681 16495754 16244371 16144979 17875725
MESH:D006333 Heart Failure Doxorubicin 10.9417481944
MESH:D006333 Heart Failure pirinixic acid 10.9420558911
MESH:D006333 Heart Failure Selenium 10.9417162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006529 Hepatomegaly Phenobarbital 12.9816109766
MESH:D006529 Hepatomegaly pirinixic acid 12.9819772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.9812621046 16120746 15340226
MESH:D006689 Hodgkin Disease Doxorubicin 3.2115147373 18501091 17606976
MESH:D019584 Hot Flashes venlafaxine 5.2814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8018606429 15340226 16354765 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 12.0316870215
MESH:D006930 Hyperalgesia Tretinoin 12.0316870215
MESH:D006930 Hyperalgesia zoledronic acid 12.0316769263
MESH:D006934 Hypercalcemia zoledronic acid 4.8319622757 18089816
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.5210459572
MESH:D006949 Hyperlipidemias Dietary Fats 3.3921332399
MESH:D006965 Hyperplasia Carbamazepine 4.9718773962
MESH:D006973 Hypertension Cyclosporine 4.6310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6318850075 18670907
MESH:D006996 Hypocalcemia zoledronic acid 5.9412669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1217937319
MESH:D007248 Infertility, Male vinclozolin 6.1216467254
MESH:D007249 Inflammation Dietary Fats 7.5320412841
MESH:D007249 Inflammation Diethylnitrosamine 7.5318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5312878042 12200463
MESH:D007251 Influenza, Human Selenium 3.9516624496
MESH:D007333 Insulin Resistance bisphenol A 11.4116393666
MESH:D007333 Insulin Resistance Dietary Fats 11.4118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 11.4116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.2218776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 9.2215369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.2516707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.2516518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.2616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.2612371664
MESH:D007680 Kidney Neoplasms Fluorouracil 11.2616985049
MESH:D007938 Leukemia Tretinoin 2.6517143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9116085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.5518089816
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.0616972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9917368321 16823087 19075265 17217047 17301526 17294898 15748426 17339181 16891316 17107899 19225113 19642359 16331271 16788101 12679006 17361223 17506722 9834237 16935935 17649720 16140955 19035177 19029980 17712046 16766008
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4816417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008103 Liver Cirrhosis Dietary Fats 10.2518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.2520032147 19638242 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 10.2521047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.4016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 6.4017481882
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.0919014921 16610002 12969438 11587558 19784758 12587719 19460945 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 6.0917034775
MESH:D008107 Liver Diseases Phenobarbital 6.0919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 9.3316871587 17185352
MESH:D017114 Liver Failure, Acute venlafaxine 9.3319857765
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.7421137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.7412771043 20583210 19254457 2422723 19499222 19090486 20101389 19073162 20137499 19256749 12112319 19833225 18978307 20434301 21278145 21047994 19426721 19850985 20501860 21167192 21071580 19551842 20452335 10737359 19642983 16942905 19638242 20492335 19294768 19255062 15175105 15885732 20118626 9163691 2862719 19996281 19690152 19427195 18644402 20405173 18648771 18754104 19812893 18977376
MESH:D008113 Liver Neoplasms Fluorouracil 16.7415113037 18383874 16603448 17045692
MESH:D008113 Liver Neoplasms Phenobarbital 16.748742319 19812893 19073162 21047994 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 16.7415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.7416984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.0418093689 9362446 17854601 19519916 21159647 19009564 2563599 19539802 18775883 18544905 3124819 18079962 16842330 16267830 19126423 19004024 17942915 17174075 18253720 18164116 18308698 18282651
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.0417085340 16842330
MESH:D008114 Liver Neoplasms, Experimental kojic acid 17.0418544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.041399818 18308698 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.0412151625
MESH:D008171 Lung Diseases Ozone 3.218266340 19066396
MESH:D055370 Lung Injury Ozone 3.6120417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.1418816296 17053015 18569708 20869020 20464547 20064080 20135361 18520028 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.1420970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 8.1417418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 8.1415246190
MESH:D008175 Lung Neoplasms Ozone 8.148597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5415086387
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5016628512
MESH:D008223 Lymphoma Doxorubicin 3.2916098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.2615458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.2615318939
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 9.2617312309
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Doxorubicin 5.0116827129
MESH:D008545 Melanoma epigallocatechin gallate 5.0111746506 17992120
MESH:D008545 Melanoma Tretinoin 5.0116752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D001523 Mental Disorders venlafaxine 4.6216856516
MESH:D008607 Mental Retardation Carbamazepine 3.649014606
MESH:D008654 Mesothelioma Doxorubicin 9.7617638057
MESH:D008654 Mesothelioma Selenium 9.7615107826
MESH:D008654 Mesothelioma zoledronic acid 9.7616675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D008679 Metaplasia Ozone 4.8610496685
MESH:D008881 Migraine Disorders venlafaxine 4.6018803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2815792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.9116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.9116757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.5417415656
MESH:D009101 Multiple Myeloma zoledronic acid 3.9116996129 19621390 18089719
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.2417962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9417596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.3715857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.3719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009224 Myotonia Congenita Carbamazepine 5.2220399394
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6118551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.109029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.1018259882
MESH:D009362 Neoplasm Metastasis zoledronic acid 9.1019139120 15867366 17312309
MESH:D009369 Neoplasms Benzo(a)pyrene 10.8411141357
MESH:D009369 Neoplasms Fluorouracil 10.8418600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 10.8417405874
MESH:D009369 Neoplasms Tretinoin 10.8416946489 16594593
MESH:D009401 Nephrosis Doxorubicin 4.5316636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.6119348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.6116889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 21.5611399458 16427766
MESH:D009421 Nervous System Malformations Carbamazepine 21.5616990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.5614600291
MESH:D009421 Nervous System Malformations Tretinoin 21.569125849
MESH:D009436 Neural Tube Defects Tretinoin 2.909142499
MESH:D009447 Neuroblastoma Doxorubicin 3.1415555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2716436463
MESH:D009765 Obesity Dietary Fats 4.2217217161 18674790 21332399 19632207 18457598 20132043 16723640 20518802 11836018
MESH:D009765 Obesity pirinixic acid 4.2220558911
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 5.4417503984
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2212819281 16049721
MESH:D010014 Osteolysis zoledronic acid 5.1215867366
MESH:D010018 Osteomalacia Carbamazepine 11.2717016548
MESH:D010018 Osteomalacia Phenobarbital 11.2717016548
MESH:D010024 Osteoporosis zoledronic acid 3.8817882678
MESH:D012516 Osteosarcoma Doxorubicin 3.9215930896
MESH:D010049 Ovarian Diseases bisphenol A 4.7411985600
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9816936753
MESH:D010051 Ovarian Neoplasms U 0126 4.9816211241
MESH:D010146 Pain Acetaminophen 14.5616870215
MESH:D010146 Pain Carbamazepine 14.5615215642
MESH:D010146 Pain Tretinoin 14.5616870215
MESH:D010146 Pain zoledronic acid 14.5616475674
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.5916540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.5919003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.5916965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.5915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010267 Parapsoriasis Carbamazepine 5.4616538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.6817145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010538 Peritonitis Ozone 3.8916369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9117983394
MESH:D010954 Plasmacytoma Selenium 4.6415087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9117638057
MESH:D011014 Pneumonia Ozone 4.1518007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.0812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.082563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.082563599
MESH:D011248 Pregnancy Complications Carbamazepine 4.919014606
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 21.2610548101
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 21.269014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.2611896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 21.2619015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9015749863 15897917 16868541 18437689 16888761 16729912
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9019082440 18626508
MESH:D011471 Prostatic Neoplasms zoledronic acid 1.9012438248 19103299
MESH:D011472 Prostatitis vinclozolin 4.6918629315
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D019310 Pseudolymphoma Carbamazepine 11.759591791 12752131
MESH:D019310 Pseudolymphoma Phenobarbital 11.7512752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5410548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8016160472 18722050 18286688 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 3.9817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D012120 Respiration Disorders Chlorine 4.9618579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.7815625365 18313854 16767912 17203757 17710206 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.8514601052 16326096
MESH:D012512 Sarcoma, Ewing's zoledronic acid 9.8516121404
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5417846226
MESH:D012640 Seizures 2,4-dinitrotoluene 9.0218551238
MESH:D012640 Seizures Carbamazepine 9.0216876388 15946322 9844417 16180713 9046859 19414003 16938433
MESH:D012640 Seizures Phenobarbital 9.0216876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.6019755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 12.6015692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.6016192470
MESH:D012878 Skin Neoplasms Tretinoin 12.6016467112
MESH:D012893 Sleep Disorders Carbamazepine 4.8819414003
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3217203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6916709447
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.9719915237 16415921 19694795 20485159 16538176 18855540 15057820
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5020155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5018396642 16951190 18567086 17172411 16424979 19084572 17522103 19015929 17498489 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 4.5017261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.7416045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.607505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.6016010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.601399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.6016026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1216280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1216051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.7616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.7617053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.7617653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0710091137
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.7416803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.7416129372
MESH:D014591 Uterine Diseases bisphenol A 4.7614652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9817678736 16364871 17334414 17638931
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31332
    • No data
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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