AutismKB 2.0

Annotation Detail for SLC23A2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC23A2 ( KIAA0238,NBTL1,SLC23A1,SVCT2,YSPL2 )
Gene Full Name: solute carrier family 23 (nucleobase transporters), member 2
Band: 20p13
Quick LinksEntrez ID:9962; OMIM: 603791; Uniprot ID:S23A2_HUMAN; ENSEMBL ID: ENSG00000089057; HGNC ID: 10973
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of vitamins and cofactors
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2239Lymphoma
Desease Name
CHEMDEPENDENCY
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLC23A2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC23A2 mRNAaffects expression 16483693
D001205 Ascorbic Acid Diclofenac inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D001205 Ascorbic Acid Estradiol inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D001205 Ascorbic Acid Genistein inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D001205 Ascorbic Acid Hydrocortisone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D001205 Ascorbic Acid Indomethacin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D001205 Ascorbic Acid Progesterone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D001205 Ascorbic Acid Quercetin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of SLC23A2 mRNAincreases expression 15912405
D002118 Calcium Calcium deficiency results in decreased expression of SLC23A2 mRNAdecreases expression 12788230
D002118 Calcium Calcium results in increased expression of SLC23A2 mRNAincreases expression 12788230
D002118 Calcium Calcium results in increased expression of SLC23A2 proteinincreases expression 12788230
D002118 Calcium Foscarnet inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]decreases reaction|increases expression 12788230
D002118 Calcium Nifedipine inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]decreases reaction|increases expression 12788230
D002220 Carbamazepine Carbamazepine results in increased expression of SLC23A2 mRNAincreases expression 17112801
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC23A2 mRNAaffects expression 17484886
D004008 Diclofenac Diclofenac inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D004958 Estradiol Estradiol inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC23A2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC23A2 mRNAaffects cotreatment|increases expression 17942748
D017245 Foscarnet Foscarnet inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]decreases reaction|increases expression 12788230
D017245 Foscarnet Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]decreases reaction|increases expression 12788230
D019833 Genistein Genistein inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D006854 Hydrocortisone Hydrocortisone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D007213 Indomethacin Indomethacin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D009543 Nifedipine Nifedipine inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]decreases reaction|increases expression 12788230
D009543 Nifedipine Nifedipine inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]decreases reaction|increases expression 12788230
D010126 Ozone GCLM gene mutant form promotes the reaction [Ozone results in increased expression of SLC23A2 mRNA]increases expression|increases reaction 20417186
D010710 Phosphates Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]decreases reaction|increases expression 12788230
D010710 Phosphates Nifedipine inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]decreases reaction|increases expression 12788230
D010710 Phosphates Phosphates deficiency results in decreased expression of SLC23A2 mRNAdecreases expression 12788230
D010710 Phosphates Phosphates results in increased expression of SLC23A2 mRNAincreases expression 12788230
D010710 Phosphates Phosphates results in increased expression of SLC23A2 proteinincreases expression 12788230
C006253 pirinixic acid pirinixic acid results in increased expression of SLC23A2 mRNAincreases expression 17426115
18301758
D011374 Progesterone Progesterone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D011794 Quercetin Quercetin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]decreases reaction|increases uptake 17092984
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC23A2 mRNAincreases expression 19684285
20106945
11489354
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC23A2 mRNAaffects cotreatment|increases expression 17942748
D014050 Toluene Toluene affects the expression of SLC23A2 mRNAaffects expression 18653662
D014415 Tunicamycin Tunicamycin results in decreased expression of SLC23A2 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 8.198986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1911752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D058186 Acute Kidney Injury Diclofenac 4.787897758
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Estradiol 9.8811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8814692618
MESH:D000230 Adenocarcinoma Genistein 9.8811473722
MESH:D000230 Adenocarcinoma Indomethacin 9.8816537180
MESH:D000236 Adenoma Indomethacin 3.3611497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D017088 AIDS-Related Opportunistic Infections Foscarnet 6.5611363124
MESH:D016301 Alveolar Bone Loss Indomethacin 5.2217225004
MESH:D000544 Alzheimer Disease Indomethacin 4.3217627676 15579461
MESH:D000544 Alzheimer Disease Ozone 4.3215513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1017084956
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.7010231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.7210388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D018771 Arthralgia Indomethacin 5.022160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.7511248219
MESH:D001172 Arthritis, Rheumatoid Ozone 4.7515570426
MESH:D001249 Asthma Ozone 2.5917854713 16373670
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8215336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Quercetin 4.2619761891
MESH:D001477 Bartter Syndrome Indomethacin 4.8310684365
MESH:D001714 Bipolar Disorder Carbamazepine 4.0620046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001929 Brain Edema Indomethacin 4.8711481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1917868700
MESH:D001930 Brain Injuries Progesterone 4.1115665606 15845082 15380490
MESH:D002545 Brain Ischemia Indomethacin 4.2712524144
MESH:D001943 Breast Neoplasms Ascorbic Acid 3.6816443354
MESH:D001943 Breast Neoplasms Estradiol 3.6817018787 17289903 16675129 14630087 18497071 17261762 12948864 19861407
MESH:D001943 Breast Neoplasms Genistein 3.6816873071 17200150 16541309
MESH:D001943 Breast Neoplasms Indomethacin 3.6817401462
MESH:D001943 Breast Neoplasms Progesterone 3.6815562024 17614352 16175315
MESH:D001943 Breast Neoplasms Quercetin 3.6818628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6820435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5618315731 19059883 17626835 14754758 18417511 15516495 16777450
MESH:D002056 Burns Indomethacin 4.5510459503
MESH:D002100 Cachexia Indomethacin 11.8916537180 15141370 11239499 15625704
MESH:D002100 Cachexia Ozone 11.8916183385
MESH:D002105 Cadmium Poisoning Quercetin 5.3916962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6316192424 15721981 10355542 16097048 3786805 16011737 16050911 15700767 18705752 16227642 16124888 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.073084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.0718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.0716924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 11.0716391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 11.0719519916 12508355
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5711053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2018791128 14736730 11352223
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8017234771
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3017341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.8112636206 15482327
MESH:D006332 Cardiomegaly Quercetin 6.5319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5318670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.2016332659
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6718566989
MESH:D002547 Cerebral Palsy Toluene 5.709294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002764 Cholecystitis Indomethacin 5.0211181007
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3717110522 15861022 17681005 11677210 16105132 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 7.3719176532
MESH:D002972 Cleft Palate Hydrocortisone 6.1015826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1016354765 12621046 8697196 15668235 15340226
MESH:D003110 Colonic Neoplasms Genistein 5.7717182828
MESH:D003110 Colonic Neoplasms Indomethacin 5.7715963497 15625704 15936596 15786552 15637740 11260862
MESH:D003110 Colonic Neoplasms Quercetin 5.7717191121 19056647 11134977 17148506 19440933 15741050 16640504
MESH:D015179 Colorectal Neoplasms Indomethacin 2.7617054584 11197048 18059344 12606626
MESH:D015179 Colorectal Neoplasms Quercetin 2.7618852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.3217323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 5.5717302372
MESH:D019465 Craniofacial Abnormalities Carbamazepine 5.439014606
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 5.4317728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.4320055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Toluene 5.439294310
MESH:D003586 Cytomegalovirus Infections Foscarnet 6.718781616 11050094
MESH:D017726 Cytomegalovirus Retinitis Foscarnet 6.7311363124
MESH:D003643 Death Toluene 5.526431079
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6119496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 7.0116506275
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.0116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3417187935
MESH:D003967 Diarrhea Hydrocortisone 8.167237001
MESH:D003967 Diarrhea Indomethacin 8.167237001 7907874
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.2911748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3220216337 15057820 16538176 16538175
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.6312958197 18713872 16109766 12153990 16081117 11287661 12594235 15619225 16485898 10915739 14986274 14550746 16177239 17906064 14725611 12540782 11834606 19923254 16781746 2444490 10774834 12705907 16393943 11743745 19416960 19164858 11461765 10663392 18071297 11529661 17562736 11739529 19739265 19420014 16227642 11421492 17522070 19370779 15968718 12392966 19085960
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 8.6317465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.6321278145 6623471 17522070 19336974 9327722 15998439 7440962 16227642 15968718 10092053 10915739 19085960 4309450 11566570 7179309 3732212 2869522 6884620 15027814 16177239 7120509 3786805
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.6320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Carbamazepine 8.0320216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0311462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0018043480 17190690 18446180 12774134 16326151 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.9917351913 10671773 11535926 11595431 17045617 11991626 11595415 17202747 17151854 16699067 17329845
MESH:C538011 Eales disease Ascorbic Acid 5.329068938
MESH:D004487 Edema Diclofenac 15.3716273134
MESH:D004487 Edema Indomethacin 15.3710653021 16100529 8985016 19703484 7990266 7907874 8273558
MESH:D004487 Edema pirinixic acid 15.3712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.3711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 14.6317654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.6312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.6317692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.1811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.1811473722
MESH:D004715 Endometriosis Indomethacin 14.5315652904
MESH:D004715 Endometriosis Progesterone 14.5316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.5310568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.3518509659
MESH:D004751 Enteritis Indomethacin 4.5917763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.8317980183
MESH:D004802 Eosinophilia Indomethacin 3.9011298111
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.1116538176 20485159 19915237 16415921 18855540
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.0617275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.8215008574 16628512 17116037
MESH:D004827 Epilepsy Carbamazepine 3.92821787 20417680 18234410 9014606 7988514 17178248 19700373 19439326 17465707 19620853
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.207750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 4.9715276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 5.5719549232
MESH:D004938 Esophageal Neoplasms Indomethacin 2.7711005569
MESH:D005076 Exanthema Carbamazepine 5.3120485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.2419224547 12631006 17595544 12795759 61145 16045604 16239168 15959796
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.2415345470
MESH:D005234 Fatty Liver pirinixic acid 12.2419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005334 Fever Indomethacin 3.9810431976 11852909 17627676
MESH:D005354 Fibrosarcoma Indomethacin 4.7410962813
MESH:D005355 Fibrosis Carbon Tetrachloride 19.9618705752
MESH:D005355 Fibrosis Indomethacin 19.9617994277
MESH:D005355 Fibrosis Quercetin 19.9619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.9620067830
MESH:D005499 Folliculitis Indomethacin 5.0211298111
MESH:D005756 Gastritis Acetaminophen 10.6416983495
MESH:D005756 Gastritis Indomethacin 10.6415046732
MESH:D005909 Glioblastoma Genistein 11.4416598420
MESH:D005909 Glioblastoma Indomethacin 11.4412870263
MESH:D005909 Glioblastoma Quercetin 11.4419804834
MESH:D005910 Glioma Indomethacin 6.1218371953 16487511
MESH:D005910 Glioma Quercetin 6.1217643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1611849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006073 Gout Indomethacin 5.2011248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.6415482327
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 6.5916080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.4315633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5315135802
MESH:D006521 Hepatitis, Chronic Diclofenac 5.5214986274
MESH:D006529 Hepatomegaly pirinixic acid 7.7616221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7615340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.4216863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D015658 HIV Infections Foscarnet 5.0011362904 11050094
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.4316870215
MESH:D006930 Hyperalgesia Indomethacin 7.4312727271
MESH:D034321 Hyperamylasemia Indomethacin 5.5717883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006940 Hyperemia Indomethacin 4.8512524144
MESH:D006943 Hyperglycemia pirinixic acid 8.8020558911
MESH:D006943 Hyperglycemia Quercetin 8.8011834736 18262572
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.6010459572
MESH:D006949 Hyperlipidemias Indomethacin 4.0217546600
MESH:D006965 Hyperplasia Carbamazepine 5.0618773962
MESH:D006973 Hypertension Nifedipine 8.5320102058
MESH:D006973 Hypertension Quercetin 8.5318356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D007015 Hypophosphatemia, Familial Foscarnet 7.288948520
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 4.8710574470 18306037
MESH:D007079 Ileitis Indomethacin 5.2016133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.2216133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2515869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3917937319
MESH:D007249 Inflammation Diclofenac 11.4116273134
MESH:D007249 Inflammation Indomethacin 11.4112568917 7812673 3291741
MESH:D007249 Inflammation Progesterone 11.4115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.4112878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.3616624496
MESH:D007333 Insulin Resistance Estradiol 6.8716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.8716306350
MESH:D007410 Intestinal Diseases Indomethacin 4.1715610444 15831440 10210152 17329856 11686837 11713966 11855677 18236018 17994277
MESH:D019586 Intracranial Hypertension Indomethacin 5.2215241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007579 Jejunal Diseases Indomethacin 4.8710574470 18306037 16133968
MESH:D007627 Keloid Quercetin 4.8017086741
MESH:D007674 Kidney Diseases Acetaminophen 13.7612587719 15629191
MESH:D007674 Kidney Diseases Estradiol 13.7615618244
MESH:D007674 Kidney Diseases Indomethacin 13.7617190690
MESH:D007674 Kidney Diseases Quercetin 13.7616962696
MESH:D007680 Kidney Neoplasms Estradiol 2.8615610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.8916316344
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7811703811 12228301 10320625
MESH:D007938 Leukemia Genistein 6.3117468513 18980019
MESH:D007938 Leukemia Quercetin 6.3117468513
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8110785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6118360721
MESH:D007964 Leukocytosis Indomethacin 5.2216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5717980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5711479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7317334410 16943688 16221502 17157831 21278145 11408273 17174718 11903743 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.6418187930 12586293 13678700 17761835 14724832 18279442 14512876 12546737 18156304 15338365 15925388 16638106 17565644 12898905 17823541 15673190 12958196 18412020 18429990 15730626 14748882 17805973 12632512 15996030 16015684 12632514 15959796 18210741 17525996 17721639 16192424 18339082 18263696 15931870 14716833 17714472 18166357 17708605 16011737 18395914 16136751 17557913 18054572 16248980 17976157 15818738 18472332 12741479 18420326 18205269 15370692 18376398 20821823 18251166 17944888 15362042 17698563 15123356 17640975 17922224 18705752 10355542 12445421 16116963 18277467 17631135 17766677 12445418 15876570 18418968 18481824 11481614 12667390 17900296 12609069 17481882 16097048 12649538 18472094 18006644 16033810 15650968 12389079 14716496 17869086 18317297 18395095 15893842 15052691 16027843 14620537 15057751 12666154
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.6414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.6417823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 10.6418194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.6415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.6412741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.6412878042
MESH:D008107 Liver Diseases Acetaminophen 6.4519014921 11587558 12969438 12587719 19460945 19784758 16611625 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4515830285 17285989 15720792 16964402 16246199
MESH:D008107 Liver Diseases Diclofenac 6.4514566034 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.2219294768
MESH:D008113 Liver Neoplasms pirinixic acid 10.2216377806 15890375 20007298
MESH:D008113 Liver Neoplasms Quercetin 10.2218980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.2216984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 13.4018544905
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.4015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Quercetin 13.4019519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.4012151625
MESH:D008171 Lung Diseases Ascorbic Acid 7.4616863852
MESH:D008171 Lung Diseases Ozone 7.468266340 19066396
MESH:D055370 Lung Injury Ozone 3.7020417186
MESH:D008175 Lung Neoplasms Ascorbic Acid 6.4216401635
MESH:D008175 Lung Neoplasms Indomethacin 6.4211497255 11053908 16537180
MESH:D008175 Lung Neoplasms Ozone 6.428597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 6.4216280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4211884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5316628512
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4511807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.4514578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.4517203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D001523 Mental Disorders Phosphates 4.8612686366
MESH:D008607 Mental Retardation Carbamazepine 6.359014606
MESH:D008607 Mental Retardation Toluene 6.359294310
MESH:D008679 Metaplasia Ozone 4.9610496685
MESH:D008881 Migraine Disorders Indomethacin 3.5711903285
MESH:D019957 Motor Skills Disorders Toluene 5.099294310
MESH:D009062 Mouth Neoplasms Indomethacin 3.8712636206
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction Genistein 9.1317141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.1319151258
MESH:D009203 Myocardial Infarction Quercetin 9.1319595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 19.3316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 19.3317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 19.3316411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 19.3319207477
MESH:D009224 Myotonia Congenita Carbamazepine 5.3120399394
MESH:D009362 Neoplasm Metastasis Indomethacin 3.1111053908 11239499 16537180
MESH:D009369 Neoplasms pirinixic acid 4.8117405874
MESH:D009369 Neoplasms Quercetin 4.8115185748
MESH:D009374 Neoplasms, Experimental Indomethacin 3.9915625704 10663608
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009421 Nervous System Malformations Carbamazepine 22.2816990009
MESH:D009421 Nervous System Malformations Estradiol 22.2811399458 16427766
MESH:D009421 Nervous System Malformations Genistein 22.2816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.2814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9918514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.9912349958
MESH:D020078 Neurogenic Inflammation Quercetin 4.2217929310
MESH:D009765 Obesity Ascorbic Acid 4.6217217161
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.026374098
MESH:D010003 Osteoarthritis Diclofenac 7.9118287210
MESH:D010003 Osteoarthritis Indomethacin 7.917009135
MESH:D010018 Osteomalacia Carbamazepine 5.3117016548
MESH:D010024 Osteoporosis Calcium 7.1717882678
MESH:D010024 Osteoporosis Genistein 7.1719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.6616169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.6619495926
MESH:D010051 Ovarian Neoplasms Estradiol 10.9319401270
MESH:D010051 Ovarian Neoplasms Genistein 10.9319005980
MESH:D010051 Ovarian Neoplasms Progesterone 10.9316525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 10.9319005980
MESH:D010146 Pain Acetaminophen 15.2116870215
MESH:D010146 Pain Carbamazepine 15.2115215642
MESH:D010146 Pain Diclofenac 15.2113679232
MESH:D010146 Pain Indomethacin 15.2113679232 17440234 3291741 17627676
MESH:D010149 Pain, Postoperative Indomethacin 4.5318702446 12538197
MESH:D010190 Pancreatic Neoplasms Quercetin 2.8016965848
MESH:D010195 Pancreatitis Indomethacin 3.7817883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5716537180
MESH:D010267 Parapsoriasis Carbamazepine 5.5516538176
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9812349958
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.7717679678 17145499
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5711903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0011148446
MESH:D010518 Periodontitis Indomethacin 4.7617225004
MESH:D010538 Peritonitis Ozone 3.9816369182
MESH:D011014 Pneumonia Ozone 4.2418007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Quercetin 3.8519056647
MESH:D011248 Pregnancy Complications Carbamazepine 5.009014606
MESH:D047928 Premature Birth Indomethacin 4.9817000239
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 9.359014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3511118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.6716740699
MESH:D011471 Prostatic Neoplasms Genistein 2.6716925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Quercetin 2.6717292933 14715546
MESH:D011507 Proteinuria Indomethacin 4.0211849393
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D019310 Pseudolymphoma Carbamazepine 5.459591791 12752131
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.1814606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2716849425
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.3916862918
MESH:D012640 Seizures Carbamazepine 6.4316180713 15946322 16876388 16938433 9046859 19414003 9844417
MESH:D012640 Seizures Toluene 6.436431079 9294310
MESH:D012871 Skin Diseases Ascorbic Acid 3.1718709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D012893 Sleep Disorders Carbamazepine 4.9719414003
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1316503802 15862959
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.0616538176 19694795 20485159 15057820 19915237 18855540 16415921
MESH:D013272 Stomach Diseases Indomethacin 4.2718209964 15472012 16113693 17160473 10215738 15038085 10486359 17207306 10192188 17638125 16184426 16280098 18545984
MESH:D013274 Stomach Neoplasms Indomethacin 2.3515609394
MESH:D013276 Stomach Ulcer Ascorbic Acid 11.6318726076
MESH:D013276 Stomach Ulcer Indomethacin 11.6310423059 16397915 17895592 12500499 11906479 16934674 10878458 14567935 18193104 12467913 18543354 12787963 17977527 17627676 17918041 18431645 11595431 18237397 16169175 12498302 16631530 15104355 17135157 10750652 17657623 18087811 1323529 18726076 17654042 18209962 11595415 15255614 16150113 16755016 12077510 18299717 11729361 16252198 11523592 18181030 11145282 15138204
MESH:D013276 Stomach Ulcer Nifedipine 11.6314653237
MESH:D020521 Stroke Ascorbic Acid 4.1716517955 16403987
MESH:D013733 Testicular Diseases Toluene 4.8010514026 10048760
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Indomethacin 3.4711352223 14736730 18791128
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014456 Ulcer Indomethacin 4.7410574470 17380554
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.7516720314
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D014839 Vomiting Indomethacin 4.5911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
REACT:11193 Metabolism of vitamins and cofactors
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved