AutismKB 2.0

Annotation Detail for CLEC2B


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Basic Information Top
Gene Symbol:CLEC2B ( AICL,CLECSF2,HP10085,IFNRG1 )
Gene Full Name: C-type lectin domain family 2, member B
Band: 12p13.31
Quick LinksEntrez ID:9976; OMIM: 603242; Uniprot ID:CLC2B_HUMAN; ENSEMBL ID: ENSG00000110852; HGNC ID: 2053
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001262 Atenolol Atenolol results in increased expression of CLEC2B mRNAincreases expression 19915711
C014347 decitabine decitabine results in decreased expression of CLEC2B mRNAdecreases expression 19194470
D007501 Iron Iron deficiency results in increased expression of CLEC2B mRNAincreases expression 20368581
D015735 Mifepristone Mifepristone results in increased expression of CLEC2B mRNAincreases expression 17584828
C004648 testosterone enanthate testosterone enanthate affects the expression of CLEC2B mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 6.1916640825
MESH:D000544 Alzheimer Disease Iron 3.0616640825 16563566
MESH:D000740 Anemia Iron 4.7216566752 16434484
MESH:D018798 Anemia, Iron-Deficiency Iron 4.9916569441 17147795 17375513 17163184 17162259
MESH:D000756 Anemia, Sideroblastic Iron 5.1916910769
MESH:D001145 Arrhythmias, Cardiac Iron 4.7216604332
MESH:D001260 Ataxia Telangiectasia Iron 5.9915336622
MESH:D050197 Atherosclerosis Iron 3.9016632123 16640825
MESH:D001321 Autistic Disorder Iron 2.7717352947
MESH:D001424 Bacterial Infections Iron 5.7316640825
MESH:D001943 Breast Neoplasms decitabine 2.5418320071 19208741
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6719215824
MESH:D006332 Cardiomegaly Atenolol 4.9215969258
MESH:D009202 Cardiomyopathies Iron 4.2616640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5516604332
MESH:D003110 Colonic Neoplasms decitabine 4.2817616700
MESH:D003110 Colonic Neoplasms Iron 4.2816640825
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D003920 Diabetes Mellitus Iron 4.7816604332 16640825
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.4416506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 3.1516506275
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.7319294695
MESH:D004715 Endometriosis Mifepristone 4.7116134523
MESH:D005234 Fatty Liver Iron 4.4616640825
MESH:D005621 Friedreich Ataxia Iron 5.9116604332 16640825
MESH:D006258 Head and Neck Neoplasms decitabine 3.7119215824
MESH:D006333 Heart Failure Atenolol 5.0220082655
MESH:D006432 Hemochromatosis Iron 4.7416604332 16574947 17255318 17053826 16640825 17236123
MESH:D006486 Hemosiderosis Iron 5.8316604332
MESH:D006525 Hepatitis, Viral, Human Iron 6.0816640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.4217182432
MESH:D006529 Hepatomegaly Iron 4.8016890145
MESH:D015658 HIV Infections Iron 3.8316597321
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.3617440010
MESH:D006973 Hypertension Atenolol 4.4019249413 11910301 11593098 14700505 12717102 15969258 15237695 15614026 15188945 15453913 12022239 14597852
MESH:D017379 Hypertrophy, Left Ventricular Atenolol 6.0515237695
MESH:D007006 Hypogonadism Iron 4.6416640825
MESH:D007037 Hypothyroidism Iron 5.5716640825
MESH:D007248 Infertility, Male decitabine 3.4217581917
MESH:D019189 Iron Metabolism Disorders Iron 5.4417163184
MESH:D007938 Leukemia decitabine 3.2219235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.3719117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4219010910 17679729 18460780 18704418 18206229 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.0718055864
MESH:D020961 Lewy Body Disease Iron 5.9116563566
MESH:D008103 Liver Cirrhosis Iron 3.9016640825
MESH:D008108 Liver Diseases, Alcoholic Iron 5.4916737972 17207112
MESH:D008113 Liver Neoplasms Iron 3.2420302851 16640825
MESH:D008175 Lung Neoplasms Iron 2.6716640825
MESH:D008223 Lymphoma decitabine 3.6619470736
MESH:D008268 Macular Degeneration Iron 4.1516640825
MESH:D008382 Marfan Syndrome Atenolol 6.7319430350
MESH:D008545 Melanoma decitabine 2.2816505122 17785578
MESH:D009101 Multiple Myeloma decitabine 3.5918172295
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 6.2817086897
MESH:D009181 Mycoses Iron 6.0816640825
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5619157545 18608210 19010910 16882708
MESH:D017202 Myocardial Ischemia Iron 4.7316604332
MESH:D015428 Myocardial Reperfusion Injury Iron 4.5416604332
MESH:D009369 Neoplasms decitabine 2.8619470736 19116145 17925555
MESH:D009404 Nephrotic Syndrome Iron 4.8417178036
MESH:D019636 Neurodegenerative Diseases Iron 4.5516604332 17296847
MESH:D010003 Osteoarthritis Iron 4.1616640825
MESH:D010024 Osteoporosis Iron 4.0616640825 16648989
MESH:D010051 Ovarian Neoplasms decitabine 5.5519259094 19331143
MESH:D010051 Ovarian Neoplasms Mifepristone 5.5516525653
MESH:D010190 Pancreatic Neoplasms decitabine 2.8619294695
MESH:D010212 Papilloma Iron 4.9712065085
MESH:D020447 Parasomnias Iron 6.6317352947
MESH:D010300 Parkinson Disease Iron 3.4216563566 16640825
MESH:D010900 Pituitary Diseases Iron 6.2816604332
MESH:D011041 Poisoning Iron 4.6916604332
MESH:D017119 Porphyria Cutanea Tarda Iron 5.4216640825
MESH:D011225 Pre-Eclampsia Iron 4.7016640825
MESH:D055728 Primary Myelofibrosis decitabine 5.2117616702
MESH:D011528 Protozoan Infections Iron 6.6316640825
MESH:D012148 Restless Legs Syndrome Iron 4.8116930377
MESH:D012208 Rhabdomyosarcoma decitabine 4.8119155313
MESH:D012878 Skin Neoplasms Iron 3.6112065085
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013398 Sudden Infant Death Iron 5.9916640825
MESH:D018382 Thyroid Hormone Resistance Syndrome Atenolol 6.879349583
MESH:D013964 Thyroid Neoplasms decitabine 3.6017967635
MESH:D014376 Tuberculosis Iron 4.2916597321
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8317616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.5217785578
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26582
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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