AutismKB 2.0

Annotation Detail for CASP8AP2


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Basic Information Top
Gene Symbol:CASP8AP2 ( CED-4,FLASH,FLJ11208,KIAA1315,RIP25 )
Gene Full Name: caspase 8 associated protein 2
Band: 6q15
Quick LinksEntrez ID:9994; OMIM: 606880; Uniprot ID:C8AP2_HUMAN; ENSEMBL ID: ENSG00000118412; HGNC ID: 1510
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1841Stomach cancer
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CASP8AP2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CASP8AP2 mRNAaffects expression 17562736
C004984 apocarotenal apocarotenal results in increased expression of CASP8AP2 mRNAincreases expression 17034753
C006632 arsenic trioxide arsenic trioxide results in increased expression of CASP8AP2 mRNAincreases expression 19730151
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CASP8AP2 mRNAaffects expression 20382639
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CASP8AP2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CASP8AP2 mRNA]decreases reaction|increases expression 17854601
D019833 Genistein Genistein results in increased expression of CASP8AP2 mRNAincreases expression 15256057
D009151 Mustard Gas Mustard Gas results in increased expression of CASP8AP2 mRNAincreases expression 15674844
C017947 sodium arsenite sodium arsenite results in increased expression of CASP8AP2 mRNAincreases expression 17879257
C017947 sodium arsenite sodium arsenite results in decreased expression of CASP8AP2 mRNAdecreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CASP8AP2 mRNAdecreases expression 18691609
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CASP8AP2 mRNAincreases expression 19465110
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of CASP8AP2 mRNAincreases expression 18087596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 15322242 11752688
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6419825857 11798837
MESH:D000230 Adenocarcinoma Genistein 4.6411473722
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.7515814487
MESH:D000236 Adenoma Diethylnitrosamine 2.936695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7119052882 16434500 18056438 19061943 17620307 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2119898480
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001768 Blister Mustard Gas 5.3519167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8617474063
MESH:D001943 Breast Neoplasms Genistein 1.8616873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1917687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.6716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.673084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.6715073043 16217749 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.6719701751 18393292 17173139 17761372 16288022 11831363 10672840 19335982 19539802 21159647 17978847 19107877 19171122 18785209 20727157 18665156 17138121 16681979 17055752 18210153 16502159 18971187 18506893 19394651 16878318 3581430 16328049 20935162 18788625 17428255 20514400 10737359 16540662 20101231 16569478 16807293 16935385 19052882 20432363 20084675 16698587 20524982 19208518 20512989 16830150 18691550 19919837 20007298 18978308 16779866 20214788 19383236 18494052 3084413 18056438 19418558 19519916 19822196 17162532
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.6716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.6717306315 16507464 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4711212258
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.1518572023
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.1511212258
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.4016332659
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7720889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.777505956 21159647 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.7719524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 16354765 12621046 8697196
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5110048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.2920387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.2916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.2917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2611834606 11287661 16781746 12153990 12958197 17906064 18071297 10663392 11421492 12705907 16485898 10915739 17562736 19739265 16081117 11739529 17522070 2444490 10774834 11529661 19085960 12540782 16109766 19420014 14986274 18713872 19416960 19164858 14725611 12594235 16177239 14550746 15968718 15619225 19370779 11743745 12392966 19923254 16227642 11461765 16393943
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Mustard Gas 7.3111428631 9260866 11402378 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004714 Endometrial Hyperplasia Genistein 4.7816402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4511473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004890 Erythema Mustard Gas 5.359357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5720426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5712903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenic trioxide 8.3415073043
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3421071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005909 Glioblastoma Genistein 3.3416598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0712621046 16120746 15340226
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 15340226 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 3.0812646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 12.5918785209
MESH:D007249 Inflammation Mustard Gas 12.5911428631 11428620 11402378 17524151 9357497 9260866 16001271 8975870 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.5912200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 12.5918590791
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.2220008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0916705839
MESH:D007938 Leukemia arsenic trioxide 6.6515070760
MESH:D007938 Leukemia Genistein 6.6517468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616968895 16467208 17050201 19850784 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3016112521 19225113 9834237 12018890 19035177 16330433 17712046 17217047 17107899 12679006 16331271 16966277 12712474 17869043 19642359 11161223 15748426 16891316 19075265 17649720 15336539 16823087 11468182 15213294 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8920032147 19638242 18407596 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4417823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4412878042
MESH:D008107 Liver Diseases Acetaminophen 4.0111587558 16610002 19460945 16611625 19784758 19014921 12587719 12969438
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1114682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.1118978307 18977376 19850985 15175105 20434301 18648771 9163691 20101389 20452335 19996281 20118626 19254457 19427195 19642983 21047994 20583210 19256749 15885732 20501860 19255062 18644402 21167192 19090486 2862719 10737359 21071580 19073162 19499222 19551842 19294768 19833225 12771043 18754104 20137499 2422723 12112319 16942905 19690152 20492335 19812893 20405173 21278145 19426721 19638242
MESH:D008113 Liver Neoplasms sodium arsenite 11.1115276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.3020377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.302563599 19009564 17854601 18544905 21159647 19539802 19004024 16267830 18775883 16842330 19126423 19519916 18079962 18308698 18093689 18282651 17942915 9362446 17174075 18164116 18253720 3124819
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008171 Lung Diseases Mustard Gas 7.8518161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 7.8519095001
MESH:D008175 Lung Neoplasms arsenic trioxide 8.7719825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.7720970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Mustard Gas 8.773148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 8.7715276417 17306315 17077188 16712894 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.7719555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 8.7716288123 3440675 11091918 12111688
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0214578162 12929590
MESH:D008545 Melanoma sodium arsenite 2.0516487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.4615006635
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2014977855 15949261 19417148 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2216882451 16105982
MESH:D009203 Myocardial Infarction Genistein 2.9117141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7717141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms sodium arsenite 2.5611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009421 Nervous System Malformations Genistein 10.1516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6310525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.6312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009503 Neutropenia Mustard Gas 4.127688884 16761898
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5616049721 12819281
MESH:D010024 Osteoporosis Genistein 3.3319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2316169203
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.1716624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Genistein 8.1719005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.1715276417 17306315
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4215580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4216540662
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D011041 Poisoning Mustard Gas 3.9415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5919131511
MESH:D011471 Prostatic Neoplasms Genistein 2.5916925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5916039940
MESH:D011537 Pruritus Mustard Gas 4.2918058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9717620002 17266442 17720292 17894541 10334151
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.8018410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Mustard Gas 2.7416961503 15451306 12880345
MESH:D012878 Skin Neoplasms sodium arsenite 9.9119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.9116192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 9.9118590791
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4717007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4718456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5519014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.557505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.4016049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.4012845720 11780464 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.4016712894 16452187 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 12.4012846360
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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