AutismKB 2.0

Annotation Detail for CDH2


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Basic Information Top
Gene Symbol:CDH2 ( CD325,CDHN,CDw325,NCAD )
Gene Full Name: cadherin 2, type 1, N-cadherin (neuronal)
Band: 18q12.1
Quick LinksEntrez ID:1000; OMIM: 114020; Uniprot ID:CADH2_HUMAN; ENSEMBL ID: ENSG00000170558; HGNC ID: 1759
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body20 / 70761282
blastocyst11 / 62319176
fetus47 / 56401283
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult69 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor17 / 26384564
glioma6 / 10688356
head and neck tumor4 / 13630229
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor7 / 9635972
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal187 / 336030755
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland5 / 33197150
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow1 / 4880120
brain83 / 110098975
cervix0 / 481710 
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue38 / 215722176
esophagus0 / 202090 
eye6 / 21105428
heart11 / 89626122
intestine3 / 23447212
kidney12 / 21177756
larynx0 / 241450 
liver9 / 20774343
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary3 / 10205129
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate4 / 18934521
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach0 / 966190 
testis50 / 330442151
thymus1 / 8113112
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203440_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.8
Adipocyte32.5
AdrenalCortex72.75
Adrenalgland79.85
Amygdala149.5
Appendix28.5
AtrioventricularNode24.05
BDCA4+_DentriticCells11.9
Bonemarrow29.15
BronchialEpithelialCells14.55
CD105+_Endothelial14.7
CD14+_Monocytes18.95
CD19+_BCells(neg._sel.)14.4
CD33+_Myeloid16.85
CD34+33.55
CD4+_Tcells16
CD56+_NKCells15.35
CD71+_EarlyErythroid14.3
CD8+_Tcells11.2
CardiacMyocytes433.05
Caudatenucleus42.35
Cerebellum43.25
CerebellumPeduncles48.2
CiliaryGanglion21.45
CingulateCortex72.3
Colorectaladenocarcinoma16.8
DorsalRootGanglion23.05
FetalThyroid29.45
Fetalbrain213.05
Fetalliver93.55
Fetallung18.55
GlobusPallidus26.25
Heart106.95
Hypothalamus97.8
Kidney24.8
Leukemia_chronicMyelogenousK-56219.45
Leukemia_promyelocytic-HL-6014.8
Leukemialymphoblastic(MOLT-4)33.35
Liver44.35
Lung26.95
Lymphnode24.05
Lymphoma_burkitts(Daudi)28.25
Lymphoma_burkitts(Raji)34.3
MedullaOblongata38.9
OccipitalLobe56.55
OlfactoryBulb22.6
Ovary18.85
Pancreas18.9
PancreaticIslet28.4
ParietalLobe69.6
Pituitary55.1
Placenta14
Pons33.55
PrefrontalCortex287.95
Prostate27.2
Salivarygland13.45
SkeletalMuscle35.7
Skin21.4
SmoothMuscle701.55
Spinalcord66.6
SubthalamicNucleus43.7
SuperiorCervicalGanglion36.5
TemporalLobe44.1
Testis84.75
TestisGermCell60.2
TestisIntersitial42.25
TestisLeydigCell35.2
TestisSeminiferousTubule78.7
Thalamus73.4
Thymus17.05
Thyroid26
Tongue22.8
Tonsil27.95
Trachea23.65
TrigeminalGanglion33.35
Uterus22.2
UterusCorpus25.4
WholeBlood15.65
Wholebrain44.1
colon15.95
pineal_day43.54
pineal_night37.4
retina48.775
small_intestine18.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15278_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.18 ± 0.23
Basal Forebrain6.81 ± 0.19
Basal Part of Pons6.62 ± 0.28
Cerebellar Cortex6.95 ± 0.25
Cerebellar Nuclei6.57 ± 0.41
Claustrum7.27 ± 0.29
Epithalamus7.04 ± 0.45
Frontal Lobe6.72 ± 0.28
Globus Pallidus6.77 ± 0.17
Hypothalamus6.58 ± 0.48
Insula6.93 ± 0.19
Limbic Lobe6.95 ± 0.35
Mesencephalon6.75 ± 0.34
Myelencephalon6.81 ± 0.39
Occipital Lobe7.25 ± 0.39
Parietal Lobe6.87 ± 0.28
Pontine Tegmentum6.92 ± 0.33
Striatum6.3 ± 0.33
Subthalamus5.92 ± 0.34
Temporal Lobe6.85 ± 0.26
Thalamus6.87 ± 0.32
White Matter6.25 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cdh2CBCerebellum22.01
41.2
Cdh2CTXCerebral cortex21.87
16.82
Cdh2HIPHippocampal region60.6
50.58
Cdh2HPFHippocampal formation56.96
49.85
Cdh2HYHypothalamus28.87
21.14
Cdh2LSXLateral septal complex16.64
12.17
Cdh2MBMidbrain15
13.24
Cdh2MYMedulla15.65
16.74
Cdh2OLFOlfactory bulb47.6
33.48
Cdh2PPons13.11
12.25
Cdh2PALPallidum17.01
15.15
Cdh2RHPRetrohippocampal region53.67
49.84
Cdh2sAMYStriatum-like amygdalar nuclei31.25
22.67
Cdh2STRStriatum9.86
7.13
Cdh2STRdStriatum dorsal region2.56
2.19
Cdh2STRvStriatum ventral region18.09
10.84
Cdh2THThalamus30.08
28.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CADH2_HUMAN_506 21 506 526 QEEGLHAGTMLTTFTAQDPDR PRIDE
CADH2_HUMAN_527 7 527 533 YMQQNIR PRIDE
CADH2_HUMAN_757 11 757 767 QLLIDPEDDVR PRIDE
PAp00043288 35 773 807 YDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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