AutismKB 2.0

Annotation Detail for HDAC6


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Basic Information Top
Gene Symbol:HDAC6 ( FLJ16239,HD6 )
Gene Full Name: histone deacetylase 6
Band: Xp11.23
Quick LinksEntrez ID:10013; OMIM: 300272; Uniprot ID:HDAC6_HUMAN; ENSEMBL ID: ENSG00000094631; HGNC ID: 14064
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst9 / 62319144
fetus64 / 564012113
neonate6 / 31097192
infant0 / 236200 
juvenile7 / 55556125
adult157 / 193912180
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor6 / 9417863
cervical tumor3 / 3436687
chondrosarcoma1 / 8282312
colorectal tumor4 / 11424635
esophageal tumor3 / 17290173
gastrointestinal tumor5 / 11936941
germ cell tumor34 / 263845128
glioma13 / 106883121
head and neck tumor8 / 13630258
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor9 / 9635993
lung tumor3 / 10312729
lymphoma7 / 7175597
non-neoplasia1 / 9725010
normal392 / 3360307116
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer10 / 10268097
retinoblastoma3 / 4635664
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites1 / 4001524
bladder1 / 2975733
blood4 / 12347832
bone4 / 7165555
bone marrow2 / 4880140
brain199 / 1100989180
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue30 / 215722139
esophagus3 / 20209148
eye16 / 21105475
heart9 / 89626100
intestine15 / 23447263
kidney10 / 21177747
larynx2 / 2414582
liver24 / 207743115
lung12 / 33697435
lymph0 / 442700 
lymph node2 / 9161021
mammary gland13 / 15327184
mouth4 / 6705259
muscle15 / 107715139
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta15 / 28082553
prostate13 / 18934568
salivary gland0 / 201550 
skin13 / 21057461
spleen2 / 5395237
stomach2 / 9661920
testis91 / 330442275
thymus18 / 81131221
thyroid2 / 4747342
tonsil0 / 169990 
trachea11 / 52413209
umbilical cord10 / 13680730
uterus28 / 232878120
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206846_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts136.4
Adipocyte161.55
AdrenalCortex173.05
Adrenalgland150.3
Amygdala147.5
Appendix176.9
AtrioventricularNode159.6
BDCA4+_DentriticCells165.4
Bonemarrow176.95
BronchialEpithelialCells138.7
CD105+_Endothelial146.2
CD14+_Monocytes125.8
CD19+_BCells(neg._sel.)142.5
CD33+_Myeloid181.4
CD34+219.6
CD4+_Tcells167.65
CD56+_NKCells162.65
CD71+_EarlyErythroid171.25
CD8+_Tcells126.85
CardiacMyocytes217.8
Caudatenucleus172.6
Cerebellum191.3
CerebellumPeduncles196.7
CiliaryGanglion113.6
CingulateCortex185.65
Colorectaladenocarcinoma172.6
DorsalRootGanglion136.15
FetalThyroid175.2
Fetalbrain218.25
Fetalliver172.1
Fetallung168.55
GlobusPallidus91.9
Heart196.1
Hypothalamus244.9
Kidney281.2
Leukemia_chronicMyelogenousK-562215.15
Leukemia_promyelocytic-HL-60125.1
Leukemialymphoblastic(MOLT-4)181
Liver264.9
Lung182.25
Lymphnode183.95
Lymphoma_burkitts(Daudi)229.2
Lymphoma_burkitts(Raji)267.35
MedullaOblongata204.8
OccipitalLobe145.05
OlfactoryBulb160.55
Ovary124.4
Pancreas134.2
PancreaticIslet182.45
ParietalLobe233.35
Pituitary314.15
Placenta188.35
Pons219
PrefrontalCortex238.15
Prostate160.8
Salivarygland144.2
SkeletalMuscle285
Skin126.45
SmoothMuscle120.05
Spinalcord211.55
SubthalamicNucleus150.4
SuperiorCervicalGanglion249.9
TemporalLobe176.95
Testis263.05
TestisGermCell178.4
TestisIntersitial160.25
TestisLeydigCell243.05
TestisSeminiferousTubule227.55
Thalamus177.4
Thymus163.55
Thyroid207.7
Tongue195.45
Tonsil168.65
Trachea141.95
TrigeminalGanglion203.3
Uterus148.25
UterusCorpus201.9
WholeBlood179.3
Wholebrain145.15
colon114.3
pineal_day400.68
pineal_night323.2
retina213.925
small_intestine78.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16781_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.49 ± 0.29
Basal Forebrain6.85 ± 0.28
Basal Part of Pons6.49 ± 0.41
Cerebellar Cortex7.11 ± 0.29
Cerebellar Nuclei6.85 ± 0.21
Claustrum6.23 ± 0.46
Epithalamus7.05 ± 0.39
Frontal Lobe6.77 ± 0.39
Globus Pallidus6.79 ± 0.14
Hypothalamus7.29 ± 0.34
Insula6.89 ± 0.26
Limbic Lobe6.57 ± 0.39
Mesencephalon6.81 ± 0.38
Myelencephalon6.76 ± 0.33
Occipital Lobe6.74 ± 0.29
Parietal Lobe6.67 ± 0.37
Pontine Tegmentum6.78 ± 0.44
Striatum6.45 ± 0.28
Subthalamus6.89 ± 0.27
Temporal Lobe6.81 ± 0.33
Thalamus6.79 ± 0.3
White Matter7.37 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hdac6CBCerebellum13.16
13.01
Hdac6CTXCerebral cortex27.71
19.14
Hdac6HIPHippocampal region23.67
24.98
Hdac6HPFHippocampal formation25.06
22.6
Hdac6HYHypothalamus33.51
23.7
Hdac6LSXLateral septal complex23.31
15.33
Hdac6MBMidbrain21.4
17.99
Hdac6MYMedulla21.68
19.75
Hdac6OLFOlfactory bulb36.65
26.38
Hdac6PPons24.15
20.97
Hdac6PALPallidum27.65
21.31
Hdac6RHPRetrohippocampal region27.36
20.18
Hdac6sAMYStriatum-like amygdalar nuclei29.21
20.23
Hdac6STRStriatum11.56
8.13
Hdac6STRdStriatum dorsal region5.7
4.33
Hdac6STRvStriatum ventral region16.49
10.74
Hdac6THThalamus24.04
17.31
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HDAC6_HUMAN_1207 9 1207 1215 FGEDMPHPH PRIDE
HDAC6_HUMAN_2 11 2 12 TSTGQDSTTTR PRIDE
HDAC6_HUMAN_715 7 715 721 YLAAWHR PRIDE
HDAC6_HUMAN_796 32 796 827 SLLGDPPPLLTLPRPPLSGALASITETIQVHR PRIDE
PAp00040391 28 746 773 GDPLGGCQVSPEGYAHLTHLLMGLASGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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