AutismKB 2.0

Annotation Detail for PDCD6


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Basic Information Top
Gene Symbol:PDCD6 ( ALG-2,FLJ46208,MGC111017,MGC119050,MGC9123,PEF1B )
Gene Full Name: programmed cell death 6
Band: 5p15.33
Quick LinksEntrez ID:10016; OMIM: 601057; Uniprot ID:PDCD6_HUMAN; ENSEMBL ID: ENSG00000063438,ENSG00000249915; HGNC ID: 8765
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst7 / 62319112
fetus33 / 56401258
neonate0 / 310970 
infant2 / 2362084
juvenile2 / 5555635
adult96 / 193912149
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor10 / 94178106
cervical tumor4 / 34366116
chondrosarcoma4 / 8282348
colorectal tumor8 / 11424670
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor8 / 26384530
glioma9 / 10688384
head and neck tumor10 / 13630273
kidney tumor4 / 6895958
leukemia8 / 9584283
liver tumor3 / 9635931
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal199 / 336030759
ovarian tumor2 / 7668226
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites1 / 4001524
bladder0 / 297570 
blood7 / 12347856
bone3 / 7165541
bone marrow4 / 4880181
brain104 / 110098994
cervix8 / 48171166
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue21 / 21572297
esophagus1 / 2020949
eye8 / 21105437
heart7 / 8962678
intestine16 / 23447268
kidney7 / 21177733
larynx4 / 24145165
liver9 / 20774343
lung15 / 33697444
lymph0 / 442700 
lymph node5 / 9161054
mammary gland12 / 15327178
mouth3 / 6705244
muscle5 / 10771546
nerve2 / 15768126
ovary5 / 10205148
pancreas19 / 21481288
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate4 / 18934521
salivary gland0 / 201550 
skin10 / 21057447
spleen1 / 5395218
stomach7 / 9661972
testis24 / 33044272
thymus2 / 8113124
thyroid3 / 4747363
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus17 / 23287872
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203415_at
Cell line Expression level Expression bar
721_B_lymphoblasts145.65
Adipocyte46.55
AdrenalCortex30.55
Adrenalgland35.3
Amygdala118.8
Appendix19.95
AtrioventricularNode9.8
BDCA4+_DentriticCells135.05
Bonemarrow38.55
BronchialEpithelialCells105.6
CD105+_Endothelial106.2
CD14+_Monocytes260.7
CD19+_BCells(neg._sel.)141.65
CD33+_Myeloid200.45
CD34+277.7
CD4+_Tcells107.95
CD56+_NKCells186.55
CD71+_EarlyErythroid48.35
CD8+_Tcells120.3
CardiacMyocytes58.1
Caudatenucleus40.8
Cerebellum42.55
CerebellumPeduncles45.55
CiliaryGanglion9.4
CingulateCortex32.3
Colorectaladenocarcinoma118.35
DorsalRootGanglion19.25
FetalThyroid48.2
Fetalbrain42.8
Fetalliver34.6
Fetallung49.95
GlobusPallidus23
Heart36.15
Hypothalamus74.8
Kidney30.15
Leukemia_chronicMyelogenousK-56281.4
Leukemia_promyelocytic-HL-6083.55
Leukemialymphoblastic(MOLT-4)50.65
Liver39.75
Lung156.45
Lymphnode41.8
Lymphoma_burkitts(Daudi)58.05
Lymphoma_burkitts(Raji)124.2
MedullaOblongata37.25
OccipitalLobe50
OlfactoryBulb33.5
Ovary18.8
Pancreas27.95
PancreaticIslet40.45
ParietalLobe42.6
Pituitary47.95
Placenta92.95
Pons29.3
PrefrontalCortex41.3
Prostate129.9
Salivarygland37.75
SkeletalMuscle18.9
Skin13.45
SmoothMuscle156
Spinalcord53.55
SubthalamicNucleus33.7
SuperiorCervicalGanglion15.85
TemporalLobe33.25
Testis29.05
TestisGermCell40.35
TestisIntersitial23.8
TestisLeydigCell31.15
TestisSeminiferousTubule23.85
Thalamus50.55
Thymus62.55
Thyroid181.25
Tongue30.25
Tonsil41.05
Trachea35.6
TrigeminalGanglion8.75
Uterus57.8
UterusCorpus27.55
WholeBlood79.85
Wholebrain118
colon70.8
pineal_day52.44
pineal_night55.8
retina65.875
small_intestine67.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8814_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.55 ± 0.3
Basal Forebrain8.6 ± 0.16
Basal Part of Pons8.58 ± 0.24
Cerebellar Cortex8.61 ± 0.18
Cerebellar Nuclei8.61 ± 0.1
Claustrum8.45 ± 0.16
Epithalamus8.78 ± 0.15
Frontal Lobe8.6 ± 0.22
Globus Pallidus8.5 ± 0.2
Hypothalamus8.79 ± 0.16
Insula8.54 ± 0.21
Limbic Lobe8.6 ± 0.25
Mesencephalon8.66 ± 0.24
Myelencephalon8.53 ± 0.26
Occipital Lobe8.53 ± 0.24
Parietal Lobe8.57 ± 0.22
Pontine Tegmentum8.48 ± 0.23
Striatum8.12 ± 0.23
Subthalamus8.83 ± 0.16
Temporal Lobe8.6 ± 0.22
Thalamus8.3 ± 0.16
White Matter8.33 ± 0.08
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pdcd6CBCerebellum11.41
23.88
Pdcd6CTXCerebral cortex37.44
35.29
Pdcd6HIPHippocampal region22.85
31.68
Pdcd6HPFHippocampal formation20.52
25.66
Pdcd6HYHypothalamus6.32
5.34
Pdcd6LSXLateral septal complex15.81
12.4
Pdcd6MBMidbrain10.15
13.31
Pdcd6MYMedulla15.71
28.64
Pdcd6OLFOlfactory bulb27.35
29.51
Pdcd6PPons15.52
25.31
Pdcd6PALPallidum11.7
12.82
Pdcd6RHPRetrohippocampal region16.87
17.46
Pdcd6sAMYStriatum-like amygdalar nuclei2.38
2.59
Pdcd6STRStriatum34.25
28.01
Pdcd6STRdStriatum dorsal region37.84
30.63
Pdcd6STRvStriatum ventral region43.8
35.96
Pdcd6THThalamus16.33
15.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00385244 13 78 90 AGVNFSEFTGVWK Peptide Atlas
PDCD6_HUMAN_0 0 0 0 LSDQFHDILIR PRIDE
PDCD6_HUMAN_100 16 100 115 TYDRDNSGMIDKNELK PRIDE
PDCD6_HUMAN_104 12 104 115 DNSGMIDKNELK PRIDE
PDCD6_HUMAN_116 9 116 124 QALSGFGYR PRIDE
PDCD6_HUMAN_125 11 125 135 LSDQFHDILIR PRIDE
PDCD6_HUMAN_66 11 66 76 SIISMFDRENK PRIDE
PDCD6_HUMAN_77 13 77 89 AGVNFSEFTGVWK PRIDE
PDCD6_HUMAN_90 10 90 99 YITDWQNVFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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