AutismKB 2.0

Annotation Detail for BCL2L11


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Basic Information Top
Gene Symbol:BCL2L11 ( BAM,BIM,BIM-alpha6,BIM-beta6,BIM-beta7,BOD,BimEL,BimL )
Gene Full Name: BCL2-like 11 (apoptosis facilitator)
Band: 2q13
Quick LinksEntrez ID:10018; OMIM: 603827; Uniprot ID:B2L11_HUMAN; ENSEMBL ID: ENSG00000153094; HGNC ID: 994
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst2 / 6231932
fetus39 / 56401269
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor8 / 26384530
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia6 / 9584262
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal136 / 336030740
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood8 / 12347864
bone4 / 7165555
bone marrow0 / 488010 
brain5 / 11009894
cervix1 / 4817120
connective tissue5 / 14925533
ear1 / 1621261
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye11 / 21105452
heart5 / 8962655
intestine10 / 23447242
kidney5 / 21177723
larynx0 / 241450 
liver4 / 20774319
lung10 / 33697429
lymph2 / 4427045
lymph node14 / 91610152
mammary gland1 / 1532716
mouth1 / 6705214
muscle3 / 10771527
nerve1 / 1576863
ovary0 / 1020510 
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta10 / 28082535
prostate8 / 18934542
salivary gland1 / 2015549
skin4 / 21057418
spleen1 / 5395218
stomach0 / 966190 
testis11 / 33044233
thymus9 / 81131110
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208536_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.4
Adipocyte5.2
AdrenalCortex5.9
Adrenalgland4.6
Amygdala5.4
Appendix5.7
AtrioventricularNode4.65
BDCA4+_DentriticCells5.6
Bonemarrow5.45
BronchialEpithelialCells5.2
CD105+_Endothelial5.35
CD14+_Monocytes5.65
CD19+_BCells(neg._sel.)5.55
CD33+_Myeloid6.65
CD34+6.65
CD4+_Tcells5.65
CD56+_NKCells6.05
CD71+_EarlyErythroid5.05
CD8+_Tcells4.8
CardiacMyocytes7.35
Caudatenucleus4.75
Cerebellum4.3
CerebellumPeduncles6.15
CiliaryGanglion4.2
CingulateCortex5.55
Colorectaladenocarcinoma5.3
DorsalRootGanglion4.35
FetalThyroid5.2
Fetalbrain5.2
Fetalliver4.65
Fetallung4.25
GlobusPallidus4.05
Heart7.3
Hypothalamus5.55
Kidney4.6
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-604.7
Leukemialymphoblastic(MOLT-4)4.2
Liver7.8
Lung5.8
Lymphnode4.5
Lymphoma_burkitts(Daudi)7
Lymphoma_burkitts(Raji)8.05
MedullaOblongata4.75
OccipitalLobe4.75
OlfactoryBulb4.15
Ovary3.7
Pancreas4.35
PancreaticIslet5.75
ParietalLobe5.85
Pituitary6.15
Placenta5.35
Pons5.15
PrefrontalCortex6.4
Prostate6.1
Salivarygland4.35
SkeletalMuscle7.3
Skin4.35
SmoothMuscle5.95
Spinalcord5.65
SubthalamicNucleus4.95
SuperiorCervicalGanglion6.55
TemporalLobe4.85
Testis4.5
TestisGermCell4.3
TestisIntersitial4.45
TestisLeydigCell5.45
TestisSeminiferousTubule4.55
Thalamus5.5
Thymus4.1
Thyroid6.45
Tongue5.4
Tonsil5.15
Trachea4.4
TrigeminalGanglion5.85
Uterus4.25
UterusCorpus5
WholeBlood5.75
Wholebrain4.4
colon5.3
pineal_day6.5
pineal_night6.36
retina6.375
small_intestine5.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P122921
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.93 ± 0.63
Basal Forebrain4.85 ± 0.43
Basal Part of Pons5 ± 0.22
Cerebellar Cortex4.63 ± 0.46
Cerebellar Nuclei5.49 ± 0.56
Claustrum5.4 ± 0.48
Epithalamus5.91 ± 0.64
Frontal Lobe4.91 ± 0.48
Globus Pallidus6.1 ± 0.3
Hypothalamus4.98 ± 0.3
Insula4.92 ± 0.43
Limbic Lobe4.59 ± 0.51
Mesencephalon4.97 ± 0.6
Myelencephalon5 ± 0.6
Occipital Lobe5.01 ± 0.48
Parietal Lobe5.01 ± 0.42
Pontine Tegmentum4.96 ± 0.51
Striatum5.44 ± 0.42
Subthalamus4.66 ± 0.46
Temporal Lobe4.86 ± 0.47
Thalamus4.92 ± 0.52
White Matter6.35 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Bcl2l11CBCerebellum8.32
9.62
Bcl2l11CTXCerebral cortex10.6
7.51
Bcl2l11HIPHippocampal region7.88
7.79
Bcl2l11HPFHippocampal formation9.1
7.88
Bcl2l11HYHypothalamus6.5
5.78
Bcl2l11LSXLateral septal complex0.81
0.86
Bcl2l11MBMidbrain3.54
4.06
Bcl2l11MYMedulla11.42
13.19
Bcl2l11OLFOlfactory bulb18.47
13.92
Bcl2l11PPons5.03
5.94
Bcl2l11PALPallidum6.89
6.65
Bcl2l11RHPRetrohippocampal region15.52
11.15
Bcl2l11sAMYStriatum-like amygdalar nuclei6.25
4.38
Bcl2l11STRStriatum7.04
5.25
Bcl2l11STRdStriatum dorsal region6.13
4.33
Bcl2l11STRvStriatum ventral region15.77
12.1
Bcl2l11THThalamus5.15
4.58
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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