AutismKB 2.0

Annotation Detail for GNE


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Basic Information Top
Gene Symbol:GNE ( DMRV,GLCNE,IBM2,NM,Uae1 )
Gene Full Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Band: 9p13.3
Quick LinksEntrez ID:10020; OMIM: 603824; Uniprot ID:GLCNE_HUMAN; ENSEMBL ID: ENSG00000159921; HGNC ID: 23657
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus13 / 56401223
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor12 / 13630288
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal67 / 336030719
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain15 / 110098913
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine8 / 23447234
kidney1 / 2117774
larynx1 / 2414541
liver9 / 20774343
lung7 / 33697420
lymph0 / 442700 
lymph node1 / 9161010
mammary gland6 / 15327139
mouth8 / 67052119
muscle5 / 10771546
nerve0 / 157680 
ovary0 / 1020510 
pancreas7 / 21481232
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate5 / 18934526
salivary gland0 / 201550 
skin8 / 21057437
spleen1 / 5395218
stomach1 / 9661910
testis0 / 3304420 
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea21 / 52413400
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205042_at
Cell line Expression level Expression bar
721_B_lymphoblasts81.1
Adipocyte21.8
AdrenalCortex13
Adrenalgland10.4
Amygdala39.95
Appendix14.9
AtrioventricularNode9.6
BDCA4+_DentriticCells40.8
Bonemarrow10.15
BronchialEpithelialCells15.95
CD105+_Endothelial33.05
CD14+_Monocytes18.95
CD19+_BCells(neg._sel.)36.25
CD33+_Myeloid27.45
CD34+56.2
CD4+_Tcells33.8
CD56+_NKCells24.6
CD71+_EarlyErythroid15.95
CD8+_Tcells24.2
CardiacMyocytes17.85
Caudatenucleus17.1
Cerebellum23.45
CerebellumPeduncles23.3
CiliaryGanglion9.6
CingulateCortex14.35
Colorectaladenocarcinoma12.25
DorsalRootGanglion9.8
FetalThyroid15.4
Fetalbrain25.8
Fetalliver16.05
Fetallung15.9
GlobusPallidus15.1
Heart12.9
Hypothalamus42.6
Kidney10.7
Leukemia_chronicMyelogenousK-56229.3
Leukemia_promyelocytic-HL-6020.7
Leukemialymphoblastic(MOLT-4)28.55
Liver73.55
Lung20.2
Lymphnode17.15
Lymphoma_burkitts(Daudi)11.7
Lymphoma_burkitts(Raji)24.8
MedullaOblongata22.4
OccipitalLobe20.05
OlfactoryBulb24.95
Ovary10.7
Pancreas17.15
PancreaticIslet32.55
ParietalLobe21.55
Pituitary31
Placenta301.55
Pons18
PrefrontalCortex22.5
Prostate77.45
Salivarygland48.55
SkeletalMuscle10.7
Skin17.45
SmoothMuscle21.6
Spinalcord24.5
SubthalamicNucleus13.1
SuperiorCervicalGanglion16.45
TemporalLobe14.2
Testis6.75
TestisGermCell13.2
TestisIntersitial10.2
TestisLeydigCell6.05
TestisSeminiferousTubule12.55
Thalamus34.75
Thymus10.4
Thyroid28.15
Tongue16.4
Tonsil15.65
Trachea79.4
TrigeminalGanglion17.15
Uterus35.4
UterusCorpus15.2
WholeBlood11
Wholebrain26.1
colon148.6
pineal_day41.72
pineal_night43.22
retina39.425
small_intestine17.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P216489
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.37 ± 0.38
Basal Forebrain8.78 ± 0.04
Basal Part of Pons9 ± 0.21
Cerebellar Cortex9.15 ± 0.14
Cerebellar Nuclei9.22 ± 0.28
Claustrum8.43 ± 0.51
Epithalamus8.52 ± 0.38
Frontal Lobe8.95 ± 0.28
Globus Pallidus8.73 ± 0.18
Hypothalamus9 ± 0.25
Insula9 ± 0.31
Limbic Lobe8.64 ± 0.32
Mesencephalon8.77 ± 0.34
Myelencephalon8.78 ± 0.37
Occipital Lobe8.55 ± 0.35
Parietal Lobe8.76 ± 0.32
Pontine Tegmentum8.83 ± 0.27
Striatum8.43 ± 0.29
Subthalamus9.31 ± 0.27
Temporal Lobe8.87 ± 0.29
Thalamus8.82 ± 0.25
White Matter9.76 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GneCBCerebellum2.29
2.67
GneCTXCerebral cortex2.28
0.97
GneHIPHippocampal region3.86
3.31
GneHPFHippocampal formation2.98
2.19
GneHYHypothalamus1.3
0.55
GneLSXLateral septal complex0.1
0.08
GneMBMidbrain2.47
1.57
GneMYMedulla13.4
6.83
GneOLFOlfactory bulb4.32
3.35
GnePPons6.58
3.44
GnePALPallidum4.07
1.47
GneRHPRetrohippocampal region1.46
0.59
GnesAMYStriatum-like amygdalar nuclei0.81
0.23
GneSTRStriatum0.59
0.44
GneSTRdStriatum dorsal region0.43
0.44
GneSTRvStriatum ventral region1.28
0.54
GneTHThalamus2.22
2.66
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00006939 15 163 177 SAEQHLISMCEDHDR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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