AutismKB 2.0

Annotation Detail for CDH6


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Basic Information Top
Gene Symbol:CDH6 ( KCAD )
Gene Full Name: cadherin 6, type 2, K-cadherin (fetal kidney)
Band: 5p13.3
Quick LinksEntrez ID:1004; OMIM: 603007; Uniprot ID:CADH6_HUMAN; ENSEMBL ID: ENSG00000113361; HGNC ID: 1765
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst5 / 6231980
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult47 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor29 / 263845109
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal60 / 336030717
ovarian tumor14 / 76682182
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain18 / 110098916
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine2 / 2344728
kidney22 / 211777103
larynx0 / 241450 
liver0 / 2077430 
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth2 / 6705229
muscle4 / 10771537
nerve0 / 157680 
ovary18 / 102051176
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis21 / 33044263
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205533_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7
Adipocyte6.15
AdrenalCortex7.35
Adrenalgland5.6
Amygdala6.35
Appendix7.25
AtrioventricularNode5.85
BDCA4+_DentriticCells6.3
Bonemarrow6.8
BronchialEpithelialCells6.05
CD105+_Endothelial6.2
CD14+_Monocytes6.65
CD19+_BCells(neg._sel.)6.6
CD33+_Myeloid7.7
CD34+7.75
CD4+_Tcells6.4
CD56+_NKCells7.05
CD71+_EarlyErythroid6.05
CD8+_Tcells5.7
CardiacMyocytes9.4
Caudatenucleus5.65
Cerebellum5.2
CerebellumPeduncles7.55
CiliaryGanglion5.3
CingulateCortex6.55
Colorectaladenocarcinoma6.3
DorsalRootGanglion5.65
FetalThyroid6.25
Fetalbrain6.2
Fetalliver5.6
Fetallung5
GlobusPallidus5
Heart9.65
Hypothalamus6.6
Kidney5.65
Leukemia_chronicMyelogenousK-5625.7
Leukemia_promyelocytic-HL-605.6
Leukemialymphoblastic(MOLT-4)4.85
Liver9.35
Lung6.8
Lymphnode5.2
Lymphoma_burkitts(Daudi)8.3
Lymphoma_burkitts(Raji)9.65
MedullaOblongata5.7
OccipitalLobe5.6
OlfactoryBulb5
Ovary4.5
Pancreas5.25
PancreaticIslet6.8
ParietalLobe7
Pituitary7.3
Placenta6.2
Pons6.25
PrefrontalCortex7.65
Prostate7.25
Salivarygland5.25
SkeletalMuscle8.8
Skin5.55
SmoothMuscle7.1
Spinalcord6.75
SubthalamicNucleus5.95
SuperiorCervicalGanglion8.8
TemporalLobe5.95
Testis5.4
TestisGermCell5.05
TestisIntersitial5.35
TestisLeydigCell6.55
TestisSeminiferousTubule5.35
Thalamus6.55
Thymus4.8
Thyroid7.65
Tongue6.75
Tonsil6.25
Trachea5.2
TrigeminalGanglion7.25
Uterus5.05
UterusCorpus6.2
WholeBlood6.85
Wholebrain5.1
colon6.35
pineal_day7.68
pineal_night7.54
retina7.625
small_intestine6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P214011
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.05 ± 0.67
Basal Forebrain5.84 ± 0.42
Basal Part of Pons4.63 ± 0.84
Cerebellar Cortex4.84 ± 0.51
Cerebellar Nuclei6.26 ± 0.37
Claustrum4.9 ± 0.94
Epithalamus5.5 ± 0.78
Frontal Lobe5.98 ± 0.75
Globus Pallidus5.93 ± 0.36
Hypothalamus5.59 ± 0.34
Insula5.7 ± 0.27
Limbic Lobe5.18 ± 0.79
Mesencephalon6.1 ± 0.61
Myelencephalon5.91 ± 0.77
Occipital Lobe5.97 ± 0.69
Parietal Lobe5.75 ± 0.61
Pontine Tegmentum6.11 ± 0.63
Striatum7.49 ± 0.58
Subthalamus5.26 ± 0.79
Temporal Lobe5.49 ± 0.48
Thalamus6.76 ± 0.62
White Matter4.66 ± 0.9
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cdh6CBCerebellum0.48
1.04
Cdh6CTXCerebral cortex0.85
0.97
Cdh6HIPHippocampal region0.25
0.36
Cdh6HPFHippocampal formation0.22
0.28
Cdh6HYHypothalamus0.4
0.28
Cdh6LSXLateral septal complex0.31
0.34
Cdh6MBMidbrain0.59
0.57
Cdh6MYMedulla1.25
2.17
Cdh6OLFOlfactory bulb3.17
2.89
Cdh6PPons0.86
1.18
Cdh6PALPallidum0.49
0.45
Cdh6RHPRetrohippocampal region0.12
0.13
Cdh6sAMYStriatum-like amygdalar nuclei0.11
0.08
Cdh6STRStriatum0.32
0.3
Cdh6STRdStriatum dorsal region0.32
0.28
Cdh6STRvStriatum ventral region0.48
0.52
Cdh6THThalamus0.74
0.64
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00092978 13 149 161 IHDINDNEPIFTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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