AutismKB 2.0

Annotation Detail for NR1H3


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Basic Information Top
Gene Symbol:NR1H3 ( LXR-a,LXRA,RLD-1 )
Gene Full Name: nuclear receptor subfamily 1, group H, member 3
Band: 11p11.2
Quick LinksEntrez ID:10062; OMIM: 602423; Uniprot ID:NR1H3_HUMAN; ENSEMBL ID: ENSG00000025434; HGNC ID: 7966
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus24 / 56401242
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult71 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor6 / 34366174
chondrosarcoma1 / 8282312
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor17 / 26384564
glioma10 / 10688393
head and neck tumor2 / 13630214
kidney tumor4 / 6895958
leukemia4 / 9584241
liver tumor5 / 9635951
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia6 / 9725061
normal166 / 336030749
ovarian tumor7 / 7668291
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue9 / 13106686
adrenal gland1 / 3319730
ascites2 / 4001549
bladder1 / 2975733
blood7 / 12347856
bone3 / 7165541
bone marrow0 / 488010 
brain21 / 110098919
cervix10 / 48171207
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart8 / 8962689
intestine12 / 23447251
kidney13 / 21177761
larynx0 / 241450 
liver9 / 20774343
lung19 / 33697456
lymph0 / 442700 
lymph node2 / 9161021
mammary gland4 / 15327126
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary10 / 10205197
pancreas2 / 2148129
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate8 / 18934542
salivary gland1 / 2015549
skin0 / 2105740 
spleen11 / 53952203
stomach3 / 9661931
testis9 / 33044227
thymus5 / 8113161
thyroid1 / 4747321
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203920_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.55
Adipocyte384.05
AdrenalCortex10.05
Adrenalgland7.1
Amygdala7.9
Appendix9.65
AtrioventricularNode6.35
BDCA4+_DentriticCells8.45
Bonemarrow7.5
BronchialEpithelialCells7.85
CD105+_Endothelial7.55
CD14+_Monocytes8.35
CD19+_BCells(neg._sel.)8.35
CD33+_Myeloid10.2
CD34+10.35
CD4+_Tcells8.2
CD56+_NKCells9.75
CD71+_EarlyErythroid7.15
CD8+_Tcells7.3
CardiacMyocytes10.2
Caudatenucleus7.15
Cerebellum6.45
CerebellumPeduncles8.95
CiliaryGanglion7.2
CingulateCortex8.05
Colorectaladenocarcinoma7.9
DorsalRootGanglion6.05
FetalThyroid7.85
Fetalbrain7.8
Fetalliver12.95
Fetallung12.4
GlobusPallidus5.75
Heart15.2
Hypothalamus8.75
Kidney6.6
Leukemia_chronicMyelogenousK-5627.25
Leukemia_promyelocytic-HL-606.95
Leukemialymphoblastic(MOLT-4)6.3
Liver170.3
Lung12.55
Lymphnode31.6
Lymphoma_burkitts(Daudi)10
Lymphoma_burkitts(Raji)10.9
MedullaOblongata7.25
OccipitalLobe7.05
OlfactoryBulb48.65
Ovary5.2
Pancreas7.75
PancreaticIslet9.65
ParietalLobe7.8
Pituitary9.25
Placenta19.15
Pons7.2
PrefrontalCortex9.7
Prostate9.7
Salivarygland6.3
SkeletalMuscle10.25
Skin6.2
SmoothMuscle9.1
Spinalcord8.5
SubthalamicNucleus7.15
SuperiorCervicalGanglion10.05
TemporalLobe7.2
Testis47.15
TestisGermCell10.8
TestisIntersitial8.8
TestisLeydigCell9.9
TestisSeminiferousTubule11.55
Thalamus8.05
Thymus12.15
Thyroid14
Tongue7.8
Tonsil9.15
Trachea6.55
TrigeminalGanglion13.4
Uterus6.65
UterusCorpus9.95
WholeBlood7.9
Wholebrain7.05
colon7.95
pineal_day9.74
pineal_night9.68
retina9.8
small_intestine10.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P47135
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.28 ± 0.28
Basal Forebrain9.35 ± 0.14
Basal Part of Pons9.24 ± 0.24
Cerebellar Cortex8.96 ± 0.08
Cerebellar Nuclei9.65 ± 0.25
Claustrum9.27 ± 0.21
Epithalamus9.38 ± 0.18
Frontal Lobe9.19 ± 0.24
Globus Pallidus9.97 ± 0.19
Hypothalamus9.24 ± 0.17
Insula9.23 ± 0.26
Limbic Lobe9.06 ± 0.36
Mesencephalon9.34 ± 0.26
Myelencephalon9.25 ± 0.24
Occipital Lobe8.98 ± 0.23
Parietal Lobe9.2 ± 0.29
Pontine Tegmentum9.21 ± 0.24
Striatum9.66 ± 0.27
Subthalamus9.49 ± 0.19
Temporal Lobe9.21 ± 0.26
Thalamus9.29 ± 0.24
White Matter9.58 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nr1h3CBCerebellum2.45
1.95
Nr1h3CTXCerebral cortex1.14
0.82
Nr1h3HIPHippocampal region1.55
0.8
Nr1h3HPFHippocampal formation1.66
1.01
Nr1h3HYHypothalamus1.11
0.9
Nr1h3LSXLateral septal complex0.16
0.11
Nr1h3MBMidbrain0.96
1.22
Nr1h3MYMedulla0.9
0.74
Nr1h3OLFOlfactory bulb3.31
1.82
Nr1h3PPons1.09
1.24
Nr1h3PALPallidum0.38
0.24
Nr1h3RHPRetrohippocampal region1.91
1.38
Nr1h3sAMYStriatum-like amygdalar nuclei0.67
0.39
Nr1h3STRStriatum0.48
0.3
Nr1h3STRdStriatum dorsal region0.35
0.26
Nr1h3STRvStriatum ventral region0.96
0.43
Nr1h3THThalamus1
0.59
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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