AutismKB 2.0

Annotation Detail for PTPRU


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Basic Information Top
Gene Symbol:PTPRU ( FLJ37530,FMI,GLEPP1,PCP-2,PTP,PTP-J,PTP-PI,PTPPSI,PTPRO,PTPU2,R-PTP-PSI,hPTP-J )
Gene Full Name: protein tyrosine phosphatase, receptor type, U
Band: 1p35.3
Quick LinksEntrez ID:10076; OMIM: 602454; Uniprot ID:PTPRU_HUMAN; ENSEMBL ID: ENSG00000060656; HGNC ID: 9683
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst7 / 62319112
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult45 / 193912123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor13 / 26384549
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal85 / 336030725
ovarian tumor1 / 7668213
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma4 / 4635686
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow2 / 4880140
brain17 / 110098915
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus0 / 202090 
eye19 / 21105490
heart0 / 896260 
intestine2 / 2344728
kidney4 / 21177718
larynx0 / 241450 
liver2 / 2077439
lung13 / 33697438
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle5 / 10771546
nerve0 / 157680 
ovary4 / 10205139
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate3 / 18934515
salivary gland1 / 2015549
skin2 / 2105749
spleen0 / 539520 
stomach2 / 9661920
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211320_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.9
Adipocyte34.8
AdrenalCortex22.35
Adrenalgland16.3
Amygdala24.15
Appendix20.1
AtrioventricularNode17.25
BDCA4+_DentriticCells11.8
Bonemarrow25.45
BronchialEpithelialCells21.85
CD105+_Endothelial14.35
CD14+_Monocytes9.7
CD19+_BCells(neg._sel.)12.1
CD33+_Myeloid16.8
CD34+8.35
CD4+_Tcells9.75
CD56+_NKCells10.05
CD71+_EarlyErythroid14.15
CD8+_Tcells13.15
CardiacMyocytes16.05
Caudatenucleus27.35
Cerebellum27.55
CerebellumPeduncles48.1
CiliaryGanglion14.8
CingulateCortex30.7
Colorectaladenocarcinoma43.8
DorsalRootGanglion12.6
FetalThyroid26.55
Fetalbrain24.15
Fetalliver18.25
Fetallung16.1
GlobusPallidus14.3
Heart46.55
Hypothalamus25.95
Kidney19
Leukemia_chronicMyelogenousK-56217.45
Leukemia_promyelocytic-HL-6018.5
Leukemialymphoblastic(MOLT-4)21.5
Liver43.4
Lung30.15
Lymphnode18.35
Lymphoma_burkitts(Daudi)26.7
Lymphoma_burkitts(Raji)29.95
MedullaOblongata30
OccipitalLobe25.95
OlfactoryBulb39.85
Ovary15.05
Pancreas17
PancreaticIslet23.15
ParietalLobe33.5
Pituitary28.05
Placenta27.9
Pons39.75
PrefrontalCortex45.35
Prostate26.9
Salivarygland18.8
SkeletalMuscle37
Skin11.75
SmoothMuscle25.55
Spinalcord24.75
SubthalamicNucleus37.7
SuperiorCervicalGanglion20.8
TemporalLobe31.3
Testis19
TestisGermCell17.55
TestisIntersitial16.2
TestisLeydigCell20.7
TestisSeminiferousTubule19.05
Thalamus30.2
Thymus15.05
Thyroid21.75
Tongue26.8
Tonsil18.3
Trachea17.55
TrigeminalGanglion19.4
Uterus14.15
UterusCorpus30.25
WholeBlood11.7
Wholebrain34.6
colon23.55
pineal_day21.4
pineal_night15.86
retina64.475
small_intestine17.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8071_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.82 ± 0.93
Basal Forebrain3.28 ± 0.37
Basal Part of Pons4.65 ± 0.27
Cerebellar Cortex3.75 ± 0.76
Cerebellar Nuclei3.78 ± 0.53
Claustrum5.11 ± 0.74
Epithalamus3.22 ± 0.46
Frontal Lobe3.78 ± 0.76
Globus Pallidus3.89 ± 1.27
Hypothalamus3.48 ± 0.45
Insula3.84 ± 0.45
Limbic Lobe3.95 ± 0.9
Mesencephalon3.91 ± 0.76
Myelencephalon3.77 ± 0.85
Occipital Lobe2.92 ± 0.8
Parietal Lobe3.8 ± 0.79
Pontine Tegmentum3.17 ± 0.72
Striatum2.39 ± 0.73
Subthalamus3.82 ± 0.51
Temporal Lobe3.74 ± 0.72
Thalamus3.29 ± 0.94
White Matter5.26 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PtpruCBCerebellum2.02
2.2
PtpruCTXCerebral cortex16.56
12.62
PtpruHIPHippocampal region14.08
20.66
PtpruHPFHippocampal formation18.62
21.63
PtpruHYHypothalamus4.17
3.55
PtpruLSXLateral septal complex2.71
2.12
PtpruMBMidbrain5.32
5.47
PtpruMYMedulla4.68
4.52
PtpruOLFOlfactory bulb4.51
3.54
PtpruPPons7.17
6.44
PtpruPALPallidum3.48
2.35
PtpruRHPRetrohippocampal region26.11
22.53
PtprusAMYStriatum-like amygdalar nuclei4.09
3.39
PtpruSTRStriatum4.71
3.63
PtpruSTRdStriatum dorsal region5.17
4.06
PtpruSTRvStriatum ventral region3.24
2.13
PtpruTHThalamus1.55
1.19
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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