AutismKB 2.0

Annotation Detail for GPC6


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Basic Information Top
Gene Symbol:GPC6 ( MGC126288,OMIMD1 )
Gene Full Name: glypican 6
Band: 13q31.3-q32.1
Quick LinksEntrez ID:10082; OMIM: 604404; Uniprot ID:GPC6_HUMAN; ENSEMBL ID: ENSG00000183098; HGNC ID: 4454
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst3 / 6231948
fetus40 / 56401270
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor11 / 94178116
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor21 / 26384579
glioma6 / 10688356
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal110 / 336030732
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow1 / 4880120
brain21 / 110098919
cervix0 / 481710 
connective tissue16 / 149255107
ear2 / 16212123
embryonic tissue26 / 215722120
esophagus0 / 202090 
eye9 / 21105442
heart2 / 8962622
intestine3 / 23447212
kidney11 / 21177751
larynx0 / 241450 
liver5 / 20774324
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland11 / 15327171
mouth1 / 6705214
muscle6 / 10771555
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate4 / 18934521
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach1 / 9661910
testis10 / 33044230
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus1 / 2328784
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P97169
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.18 ± 0.56
Basal Forebrain5.79 ± 0.79
Basal Part of Pons5.82 ± 0.41
Cerebellar Cortex5.44 ± 0.57
Cerebellar Nuclei5.26 ± 0.67
Claustrum5.21 ± 1.01
Epithalamus6.09 ± 0.64
Frontal Lobe5.98 ± 0.63
Globus Pallidus6.12 ± 0.44
Hypothalamus6.06 ± 0.5
Insula6.14 ± 0.31
Limbic Lobe5.37 ± 0.78
Mesencephalon5.9 ± 0.73
Myelencephalon5.87 ± 0.62
Occipital Lobe5.23 ± 0.53
Parietal Lobe5.54 ± 0.66
Pontine Tegmentum5.75 ± 0.62
Striatum6.29 ± 0.58
Subthalamus6.01 ± 0.77
Temporal Lobe5.73 ± 0.52
Thalamus6.09 ± 0.56
White Matter4.22 ± 0.83
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gpc6CBCerebellum16.59
16.63
Gpc6CTXCerebral cortex1.2
0.92
Gpc6HIPHippocampal region1.47
0.91
Gpc6HPFHippocampal formation1.92
1.32
Gpc6HYHypothalamus1.2
0.66
Gpc6LSXLateral septal complex0.4
0.19
Gpc6MBMidbrain0.77
1.03
Gpc6MYMedulla3.24
2.23
Gpc6OLFOlfactory bulb2.94
3.51
Gpc6PPons2.5
2.49
Gpc6PALPallidum0.22
0.16
Gpc6RHPRetrohippocampal region2.58
1.94
Gpc6sAMYStriatum-like amygdalar nuclei4.32
2.64
Gpc6STRStriatum1.03
0.67
Gpc6STRdStriatum dorsal region0.82
0.57
Gpc6STRvStriatum ventral region0.5
0.34
Gpc6THThalamus0.78
0.47
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018