AutismKB 2.0

Annotation Detail for ARPC5


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Basic Information Top
Gene Symbol:ARPC5 ( ARC16,MGC88523,dJ127C7.3,p16-Arc )
Gene Full Name: actin related protein 2/3 complex, subunit 5, 16kDa
Band: 1q25.3
Quick LinksEntrez ID:10092; OMIM: 604227; Uniprot ID:ARPC5_HUMAN; ENSEMBL ID: ENSG00000162704; HGNC ID: 708
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body27 / 70761381
blastocyst7 / 62319112
fetus103 / 564012182
neonate19 / 31097610
infant12 / 23620508
juvenile17 / 55556305
adult335 / 1939121172
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma9 / 17475515
breast (mammary gland) tumor9 / 9417895
cervical tumor8 / 34366232
chondrosarcoma16 / 82823193
colorectal tumor9 / 11424678
esophageal tumor14 / 17290809
gastrointestinal tumor30 / 119369251
germ cell tumor87 / 263845329
glioma18 / 106883168
head and neck tumor13 / 13630295
kidney tumor13 / 68959188
leukemia25 / 95842260
liver tumor23 / 96359238
lung tumor14 / 103127135
lymphoma20 / 71755278
non-neoplasia37 / 97250380
normal783 / 3360307233
ovarian tumor10 / 76682130
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS33 / 125680262
prostate cancer11 / 102680107
retinoblastoma6 / 46356129
skin tumor22 / 124949176
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor20 / 90257221
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland12 / 33197361
ascites17 / 40015424
bladder13 / 29757436
blood55 / 123478445
bone18 / 71655251
bone marrow10 / 48801204
brain237 / 1100989215
cervix13 / 48171269
connective tissue44 / 149255294
ear0 / 162120 
embryonic tissue54 / 215722250
esophagus14 / 20209692
eye25 / 211054118
heart20 / 89626223
intestine63 / 234472268
kidney37 / 211777174
larynx1 / 2414541
liver34 / 207743163
lung56 / 336974166
lymph10 / 44270225
lymph node13 / 91610141
mammary gland12 / 15327178
mouth7 / 67052104
muscle2 / 10771518
nerve3 / 15768190
ovary21 / 102051205
pancreas21 / 21481297
parathyroid2 / 2053997
pharynx4 / 4132896
pituitary gland2 / 16585120
placenta90 / 280825320
prostate20 / 189345105
salivary gland3 / 20155148
skin32 / 210574151
spleen26 / 53952481
stomach18 / 96619186
testis61 / 330442184
thymus28 / 81131345
thyroid7 / 47473147
tonsil1 / 1699958
trachea5 / 5241395
umbilical cord12 / 13680877
uterus72 / 232878309
vascular43 / 51780830
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211963_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1923.6
Adipocyte259.85
AdrenalCortex67.75
Adrenalgland99.3
Amygdala281.55
Appendix107.45
AtrioventricularNode71.05
BDCA4+_DentriticCells1528.55
Bonemarrow570.1
BronchialEpithelialCells813.85
CD105+_Endothelial239.65
CD14+_Monocytes1589
CD19+_BCells(neg._sel.)683.45
CD33+_Myeloid2051
CD34+808.9
CD4+_Tcells813
CD56+_NKCells1642.45
CD71+_EarlyErythroid200.15
CD8+_Tcells888.3
CardiacMyocytes611.25
Caudatenucleus113.7
Cerebellum49.85
CerebellumPeduncles89.4
CiliaryGanglion58.05
CingulateCortex91.4
Colorectaladenocarcinoma124.35
DorsalRootGanglion97.65
FetalThyroid133
Fetalbrain413.55
Fetalliver115.1
Fetallung356.7
GlobusPallidus47.45
Heart53.5
Hypothalamus211.85
Kidney46.85
Leukemia_chronicMyelogenousK-562125.3
Leukemia_promyelocytic-HL-60275
Leukemialymphoblastic(MOLT-4)329.2
Liver73.5
Lung431.2
Lymphnode396.9
Lymphoma_burkitts(Daudi)343.9
Lymphoma_burkitts(Raji)161
MedullaOblongata129.65
OccipitalLobe133.25
OlfactoryBulb203.6
Ovary78.35
Pancreas98.15
PancreaticIslet213
ParietalLobe127
Pituitary208.8
Placenta924.8
Pons98.3
PrefrontalCortex162
Prostate238.25
Salivarygland97.1
SkeletalMuscle78.85
Skin62.8
SmoothMuscle902.7
Spinalcord376.7
SubthalamicNucleus50.9
SuperiorCervicalGanglion155.7
TemporalLobe103.9
Testis131.4
TestisGermCell183
TestisIntersitial95.65
TestisLeydigCell98.3
TestisSeminiferousTubule111.85
Thalamus100.1
Thymus449.65
Thyroid256.35
Tongue84.35
Tonsil512
Trachea131.3
TrigeminalGanglion91.8
Uterus295
UterusCorpus105.4
WholeBlood2516.35
Wholebrain247.15
colon487.1
pineal_day174.02
pineal_night159.48
retina215.05
small_intestine427.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7785_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.84 ± 0.4
Basal Forebrain9.8 ± 0.29
Basal Part of Pons9.87 ± 0.23
Cerebellar Cortex9.73 ± 0.19
Cerebellar Nuclei10.05 ± 0.4
Claustrum9.75 ± 0.38
Epithalamus9.76 ± 0.37
Frontal Lobe10.1 ± 0.32
Globus Pallidus10.27 ± 0.24
Hypothalamus10.11 ± 0.2
Insula10.09 ± 0.26
Limbic Lobe10.07 ± 0.49
Mesencephalon9.79 ± 0.38
Myelencephalon9.96 ± 0.4
Occipital Lobe9.57 ± 0.36
Parietal Lobe9.82 ± 0.32
Pontine Tegmentum10.03 ± 0.35
Striatum9.86 ± 0.26
Subthalamus9.83 ± 0.29
Temporal Lobe10.04 ± 0.33
Thalamus9.85 ± 0.3
White Matter11.46 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Arpc5CBCerebellum3.64
5.53
Arpc5CTXCerebral cortex40.47
32.6
Arpc5HIPHippocampal region83.7
100
Arpc5HPFHippocampal formation69.72
100
Arpc5HYHypothalamus5.55
5.23
Arpc5LSXLateral septal complex46.53
54.57
Arpc5MBMidbrain4.55
4.42
Arpc5MYMedulla8.6
9.38
Arpc5OLFOlfactory bulb28.3
25.59
Arpc5PPons6.03
5.74
Arpc5PALPallidum4.36
3.69
Arpc5RHPRetrohippocampal region49.83
48.45
Arpc5sAMYStriatum-like amygdalar nuclei10.94
8.14
Arpc5STRStriatum18.21
14.83
Arpc5STRdStriatum dorsal region17.56
12.79
Arpc5STRvStriatum ventral region9.71
5.8
Arpc5THThalamus9.69
9.54
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ARPC5_HUMAN_0 0 0 0 ALAAGGVGSIVR PRIDE
ARPC5_HUMAN_0 0 0 0 QGNMTAALQAALK PRIDE
ARPC5_HUMAN_0 0 0 0 QGNMTAALQAALKNPPINTK PRIDE
ARPC5_HUMAN_1 9 1 9 SKNTVSSAR PRIDE
ARPC5_HUMAN_108 23 108 130 YIYKGFESPSDNSSAMLLQWHEK PRIDE
ARPC5_HUMAN_112 19 112 130 GFESPSDNSSAMLLQWHEK PRIDE
ARPC5_HUMAN_12 35 12 46 KVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLR PRIDE
ARPC5_HUMAN_131 12 131 142 ALAAGGVGSIVR PRIDE
ARPC5_HUMAN_2 9 2 10 SKNTVSSAR PRIDE
ARPC5_HUMAN_47 13 47 59 QGNMTAALQAALK PRIDE
ARPC5_HUMAN_47 20 47 66 QGNMTAALQAALKNPPINTK PRIDE
ARPC5_HUMAN_81 12 81 92 VLISFKANDIEK PRIDE
ARPC5_HUMAN_93 15 93 107 AVQSLDKNGVDLLMK PRIDE
PAp00004608 18 13 30 KVDVDEYDENKFVDEEDG Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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