AutismKB 2.0

Annotation Detail for ARPC4


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Basic Information Top
Gene Symbol:ARPC4 ( ARC20,MGC13544,p20-Arc )
Gene Full Name: actin related protein 2/3 complex, subunit 4, 20kDa
Band: 3p25.3
Quick LinksEntrez ID:10093; OMIM: 604226; Uniprot ID:ARPC4_HUMAN; ENSEMBL ID: ENSG00000214021,ENSG00000241553; HGNC ID: 707
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body14 / 70761197
blastocyst8 / 62319128
fetus37 / 56401265
neonate1 / 3109732
infant1 / 2362042
juvenile7 / 55556125
adult189 / 193912197
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor8 / 9417884
cervical tumor8 / 34366232
chondrosarcoma11 / 82823132
colorectal tumor30 / 114246262
esophageal tumor3 / 17290173
gastrointestinal tumor12 / 119369100
germ cell tumor21 / 26384579
glioma15 / 106883140
head and neck tumor6 / 13630244
kidney tumor4 / 6895958
leukemia15 / 95842156
liver tumor10 / 96359103
lung tumor8 / 10312777
lymphoma10 / 71755139
non-neoplasia5 / 9725051
normal263 / 336030778
ovarian tumor3 / 7668239
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS24 / 125680190
prostate cancer31 / 102680301
retinoblastoma3 / 4635664
skin tumor21 / 124949168
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood23 / 123478186
bone13 / 71655181
bone marrow7 / 48801143
brain89 / 110098980
cervix12 / 48171249
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue35 / 215722162
esophagus4 / 20209197
eye16 / 21105475
heart4 / 8962644
intestine38 / 234472162
kidney12 / 21177756
larynx0 / 241450 
liver13 / 20774362
lung24 / 33697471
lymph2 / 4427045
lymph node5 / 9161054
mammary gland13 / 15327184
mouth1 / 6705214
muscle3 / 10771527
nerve2 / 15768126
ovary6 / 10205158
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta29 / 280825103
prostate33 / 189345174
salivary gland2 / 2015599
skin23 / 210574109
spleen5 / 5395292
stomach17 / 96619175
testis11 / 33044233
thymus13 / 81131160
thyroid4 / 4747384
tonsil3 / 16999176
trachea4 / 5241376
umbilical cord1 / 1368073
uterus21 / 23287890
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217818_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts23
Adipocyte2.9
AdrenalCortex2.95
Adrenalgland2.4
Amygdala3
Appendix3
AtrioventricularNode2.2
BDCA4+_DentriticCells128.35
Bonemarrow3.5
BronchialEpithelialCells3.15
CD105+_Endothelial12
CD14+_Monocytes219.35
CD19+_BCells(neg._sel.)62
CD33+_Myeloid100.95
CD34+21.6
CD4+_Tcells22.5
CD56+_NKCells174.8
CD71+_EarlyErythroid3.75
CD8+_Tcells24.7
CardiacMyocytes3.55
Caudatenucleus2.55
Cerebellum2.3
CerebellumPeduncles3.35
CiliaryGanglion2
CingulateCortex2.9
Colorectaladenocarcinoma2.9
DorsalRootGanglion2.15
FetalThyroid2.75
Fetalbrain2.9
Fetalliver2.45
Fetallung2.4
GlobusPallidus2.05
Heart8
Hypothalamus3.15
Kidney2.25
Leukemia_chronicMyelogenousK-5622.55
Leukemia_promyelocytic-HL-602.5
Leukemialymphoblastic(MOLT-4)2.25
Liver5.75
Lung4.95
Lymphnode2.5
Lymphoma_burkitts(Daudi)3.65
Lymphoma_burkitts(Raji)3.95
MedullaOblongata2.55
OccipitalLobe2.55
OlfactoryBulb2.25
Ovary2.25
Pancreas2.25
PancreaticIslet3.05
ParietalLobe2.95
Pituitary3.35
Placenta3
Pons2.7
PrefrontalCortex3.5
Prostate3.4
Salivarygland2.35
SkeletalMuscle3.15
Skin2.3
SmoothMuscle3.25
Spinalcord3.05
SubthalamicNucleus2.6
SuperiorCervicalGanglion3.2
TemporalLobe2.6
Testis2.45
TestisGermCell2.4
TestisIntersitial2.4
TestisLeydigCell2.8
TestisSeminiferousTubule2.45
Thalamus2.9
Thymus2.65
Thyroid3.6
Tongue2.75
Tonsil2.85
Trachea2.35
TrigeminalGanglion2.85
Uterus2.4
UterusCorpus2.55
WholeBlood125.3
Wholebrain10.05
colon2.9
pineal_day3.56
pineal_night3.52
retina3.525
small_intestine2.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P29566
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.63 ± 0.46
Basal Forebrain4.98 ± 0.54
Basal Part of Pons5.49 ± 0.33
Cerebellar Cortex5.15 ± 0.46
Cerebellar Nuclei5.2 ± 0.46
Claustrum5.42 ± 0.35
Epithalamus4.9 ± 0.44
Frontal Lobe5.53 ± 0.38
Globus Pallidus5.06 ± 0.5
Hypothalamus5.17 ± 0.38
Insula5.38 ± 0.3
Limbic Lobe5.57 ± 0.53
Mesencephalon5.25 ± 0.46
Myelencephalon5.4 ± 0.55
Occipital Lobe4.87 ± 0.5
Parietal Lobe5.39 ± 0.41
Pontine Tegmentum5.27 ± 0.56
Striatum5.07 ± 0.63
Subthalamus5.51 ± 0.34
Temporal Lobe5.59 ± 0.42
Thalamus5.2 ± 0.5
White Matter5.43 ± 0.4
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ARPC4_HUMAN_0 0 0 0 ELLLQPVTISR PRIDE
ARPC4_HUMAN_1 12 1 12 TATLRPYLSAVR PRIDE
ARPC4_HUMAN_105 23 105 127 RKPVEGYDISFLITNFHTEQMYK PRIDE
ARPC4_HUMAN_106 22 106 127 KPVEGYDISFLITNFHTEQMYK PRIDE
ARPC4_HUMAN_13 19 13 31 ATLQAALCLENFSSQVVER PRIDE
ARPC4_HUMAN_130 14 130 143 LVDFVIHFMEEIDK PRIDE
ARPC4_HUMAN_158 10 158 167 IVAEEFLKNF PRIDE
ARPC4_HUMAN_158 8 158 165 IVAEEFLK PRIDE
ARPC4_HUMAN_2 12 2 13 TATLRPYLSAVR PRIDE
ARPC4_HUMAN_32 9 32 40 HNKPEVEVR PRIDE
ARPC4_HUMAN_41 14 41 54 SSKELLLQPVTISR PRIDE
ARPC4_HUMAN_42 14 42 55 SSKELLLQPVTISR PRIDE
ARPC4_HUMAN_44 11 44 54 ELLLQPVTISR PRIDE
ARPC4_HUMAN_60 11 60 70 VLIEGSINSVR PRIDE
ARPC4_HUMAN_97 8 97 104 AENFFILR PRIDE
PAp00006699 23 16 38 RKPVEGYDISFLITNFHTEQMYK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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