AutismKB 2.0

Annotation Detail for PREB


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Basic Information Top
Gene Symbol:PREB ( MGC3467,SEC12 )
Gene Full Name: prolactin regulatory element binding
Band: 2p23.3
Quick LinksEntrez ID:10113; OMIM: 606395; Uniprot ID:PREB_HUMAN; ENSEMBL ID: ENSG00000138073; HGNC ID: 9356
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst5 / 6231980
fetus21 / 56401237
neonate4 / 31097128
infant4 / 23620169
juvenile20 / 55556359
adult221 / 1939121113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor9 / 9417895
cervical tumor3 / 3436687
chondrosarcoma10 / 82823120
colorectal tumor11 / 11424696
esophageal tumor4 / 17290231
gastrointestinal tumor24 / 119369201
germ cell tumor54 / 263845204
glioma32 / 106883299
head and neck tumor11 / 13630280
kidney tumor8 / 68959116
leukemia18 / 95842187
liver tumor15 / 96359155
lung tumor14 / 103127135
lymphoma30 / 71755418
non-neoplasia8 / 9725082
normal351 / 3360307104
ovarian tumor14 / 76682182
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS45 / 125680358
prostate cancer17 / 102680165
retinoblastoma3 / 4635664
skin tumor31 / 124949248
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites16 / 40015399
bladder4 / 29757134
blood20 / 123478161
bone6 / 7165583
bone marrow4 / 4880181
brain168 / 1100989152
cervix7 / 48171145
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus4 / 20209197
eye17 / 21105480
heart11 / 89626122
intestine32 / 234472136
kidney20 / 21177794
larynx3 / 24145124
liver18 / 20774386
lung39 / 336974115
lymph11 / 44270248
lymph node9 / 9161098
mammary gland13 / 15327184
mouth3 / 6705244
muscle4 / 10771537
nerve1 / 1576863
ovary22 / 102051215
pancreas12 / 21481255
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta32 / 280825113
prostate32 / 189345169
salivary gland6 / 20155297
skin40 / 210574189
spleen10 / 53952185
stomach10 / 96619103
testis47 / 330442142
thymus18 / 81131221
thyroid3 / 4747363
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord1 / 1368073
uterus31 / 232878133
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217861_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts93.25
Adipocyte58.85
AdrenalCortex23.5
Adrenalgland31.55
Amygdala20.75
Appendix19.95
AtrioventricularNode12.45
BDCA4+_DentriticCells148.3
Bonemarrow29.55
BronchialEpithelialCells57.85
CD105+_Endothelial27.85
CD14+_Monocytes49.65
CD19+_BCells(neg._sel.)64.25
CD33+_Myeloid71.8
CD34+79
CD4+_Tcells47.85
CD56+_NKCells60.85
CD71+_EarlyErythroid35
CD8+_Tcells53.85
CardiacMyocytes32.55
Caudatenucleus15.25
Cerebellum22.15
CerebellumPeduncles24.1
CiliaryGanglion12.2
CingulateCortex22.35
Colorectaladenocarcinoma87.65
DorsalRootGanglion13.65
FetalThyroid29.3
Fetalbrain19.45
Fetalliver17.9
Fetallung33.15
GlobusPallidus11.2
Heart83.7
Hypothalamus23.55
Kidney19.75
Leukemia_chronicMyelogenousK-56222.3
Leukemia_promyelocytic-HL-6035.9
Leukemialymphoblastic(MOLT-4)62.75
Liver103.3
Lung44.55
Lymphnode41.7
Lymphoma_burkitts(Daudi)59.3
Lymphoma_burkitts(Raji)48.7
MedullaOblongata17.55
OccipitalLobe14.8
OlfactoryBulb17.7
Ovary15.65
Pancreas50.9
PancreaticIslet43.2
ParietalLobe21.4
Pituitary37.8
Placenta35.25
Pons19.25
PrefrontalCortex25.95
Prostate31.05
Salivarygland18.45
SkeletalMuscle31.5
Skin14
SmoothMuscle45.2
Spinalcord25.65
SubthalamicNucleus12.2
SuperiorCervicalGanglion18.65
TemporalLobe21.9
Testis37.1
TestisGermCell22.3
TestisIntersitial26.9
TestisLeydigCell30.55
TestisSeminiferousTubule20.3
Thalamus21
Thymus54.7
Thyroid60.75
Tongue21.45
Tonsil20
Trachea19.05
TrigeminalGanglion15.85
Uterus22.4
UterusCorpus20
WholeBlood34.8
Wholebrain32.45
colon18.35
pineal_day26.26
pineal_night22.14
retina23.725
small_intestine18.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9811_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.48 ± 0.43
Basal Forebrain4.43 ± 0.41
Basal Part of Pons4.39 ± 0.41
Cerebellar Cortex4.78 ± 0.38
Cerebellar Nuclei4.26 ± 0.57
Claustrum4.44 ± 0.61
Epithalamus4.32 ± 0.35
Frontal Lobe4.46 ± 0.44
Globus Pallidus4.55 ± 0.36
Hypothalamus4.47 ± 0.36
Insula4.45 ± 0.34
Limbic Lobe4.59 ± 0.5
Mesencephalon4.46 ± 0.49
Myelencephalon4.53 ± 0.47
Occipital Lobe4.4 ± 0.5
Parietal Lobe4.39 ± 0.46
Pontine Tegmentum4.41 ± 0.51
Striatum4.42 ± 0.47
Subthalamus4.59 ± 0.64
Temporal Lobe4.56 ± 0.51
Thalamus4.48 ± 0.48
White Matter4.85 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PrebCBCerebellum32.81
43.21
PrebCTXCerebral cortex75.59
59.26
PrebHIPHippocampal region49.02
71.12
PrebHPFHippocampal formation53.48
61.52
PrebHYHypothalamus18.64
15.05
PrebLSXLateral septal complex23.74
16.78
PrebMBMidbrain34.41
30.96
PrebMYMedulla41.59
47.02
PrebOLFOlfactory bulb54.52
46.54
PrebPPons31.59
34.96
PrebPALPallidum19.03
18.14
PrebRHPRetrohippocampal region62.15
50.36
PrebsAMYStriatum-like amygdalar nuclei25.34
18.62
PrebSTRStriatum26.83
18.97
PrebSTRdStriatum dorsal region29.55
21.18
PrebSTRvStriatum ventral region21.88
14.58
PrebTHThalamus34.19
28.28
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000395 16 194 209 AHEGEIEDLALGPDGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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