AutismKB 2.0

Annotation Detail for ACTR1B


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACTR1B ( ARP1B,CTRN2,PC3 )
Gene Full Name: ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
Band: 2q11.2
Quick LinksEntrez ID:10120; OMIM: 605144; Uniprot ID:ACTY_HUMAN; ENSEMBL ID: ENSG00000115073; HGNC ID: 168
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult140 / 193912172
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor15 / 94178159
cervical tumor5 / 34366145
chondrosarcoma8 / 8282396
colorectal tumor12 / 114246105
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor12 / 26384545
glioma16 / 106883149
head and neck tumor5 / 13630236
kidney tumor5 / 6895972
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma9 / 71755125
non-neoplasia5 / 9725051
normal156 / 336030746
ovarian tumor7 / 7668291
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS27 / 125680214
prostate cancer1 / 1026809
retinoblastoma8 / 46356172
skin tumor11 / 12494988
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites7 / 40015174
bladder0 / 297570 
blood7 / 12347856
bone8 / 71655111
bone marrow1 / 4880120
brain56 / 110098950
cervix11 / 48171228
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye30 / 211054142
heart10 / 89626111
intestine18 / 23447276
kidney13 / 21177761
larynx0 / 241450 
liver5 / 20774324
lung21 / 33697462
lymph5 / 44270112
lymph node2 / 9161021
mammary gland16 / 153271104
mouth0 / 670520 
muscle5 / 10771546
nerve3 / 15768190
ovary14 / 102051137
pancreas4 / 21481218
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta13 / 28082546
prostate8 / 18934542
salivary gland3 / 20155148
skin11 / 21057452
spleen0 / 539520 
stomach3 / 9661931
testis2 / 3304426
thymus1 / 8113112
thyroid2 / 4747342
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202135_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts274.5
Adipocyte76.6
AdrenalCortex162.9
Adrenalgland175.35
Amygdala202.55
Appendix70.2
AtrioventricularNode45.95
BDCA4+_DentriticCells160.8
Bonemarrow111
BronchialEpithelialCells73.9
CD105+_Endothelial118.05
CD14+_Monocytes161.05
CD19+_BCells(neg._sel.)314.1
CD33+_Myeloid191
CD34+205.55
CD4+_Tcells337.35
CD56+_NKCells264.15
CD71+_EarlyErythroid44.25
CD8+_Tcells296.15
CardiacMyocytes113.35
Caudatenucleus145.55
Cerebellum166.75
CerebellumPeduncles211.7
CiliaryGanglion42.75
CingulateCortex200.1
Colorectaladenocarcinoma349.3
DorsalRootGanglion67.6
FetalThyroid137.1
Fetalbrain123.1
Fetalliver93.4
Fetallung90.35
GlobusPallidus133.9
Heart292.8
Hypothalamus183.7
Kidney116.55
Leukemia_chronicMyelogenousK-562109.25
Leukemia_promyelocytic-HL-60130.35
Leukemialymphoblastic(MOLT-4)263.55
Liver256
Lung185.7
Lymphnode125.6
Lymphoma_burkitts(Daudi)185.9
Lymphoma_burkitts(Raji)237.7
MedullaOblongata205.6
OccipitalLobe200.6
OlfactoryBulb84.1
Ovary78.15
Pancreas158.65
PancreaticIslet161.65
ParietalLobe177.75
Pituitary127.2
Placenta81.65
Pons172.65
PrefrontalCortex353.45
Prostate251.15
Salivarygland98
SkeletalMuscle128.15
Skin113.1
SmoothMuscle119.95
Spinalcord131.2
SubthalamicNucleus152.4
SuperiorCervicalGanglion81.55
TemporalLobe197.4
Testis87.8
TestisGermCell77.5
TestisIntersitial59.25
TestisLeydigCell68.3
TestisSeminiferousTubule49.3
Thalamus175.5
Thymus167.65
Thyroid263.05
Tongue117.75
Tonsil123.3
Trachea102.7
TrigeminalGanglion114.7
Uterus122.15
UterusCorpus161.7
WholeBlood141.55
Wholebrain457.65
colon109.65
pineal_day283.64
pineal_night276.54
retina207.425
small_intestine92.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6537_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.9 ± 0.24
Basal Forebrain8.48 ± 0.14
Basal Part of Pons9.02 ± 0.3
Cerebellar Cortex8.54 ± 0.19
Cerebellar Nuclei8.57 ± 0.35
Claustrum9.11 ± 0.3
Epithalamus8.14 ± 0.18
Frontal Lobe8.69 ± 0.37
Globus Pallidus8.17 ± 0.28
Hypothalamus8.42 ± 0.26
Insula8.63 ± 0.26
Limbic Lobe8.87 ± 0.34
Mesencephalon8.48 ± 0.32
Myelencephalon8.67 ± 0.33
Occipital Lobe8.95 ± 0.25
Parietal Lobe8.94 ± 0.3
Pontine Tegmentum8.65 ± 0.25
Striatum8.58 ± 0.34
Subthalamus8.55 ± 0.18
Temporal Lobe8.77 ± 0.29
Thalamus8.54 ± 0.27
White Matter8.32 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Actr1bCBCerebellum97.27
100
Actr1bCTXCerebral cortex100
100
Actr1bHIPHippocampal region100
100
Actr1bHPFHippocampal formation100
100
Actr1bHYHypothalamus100
100
Actr1bLSXLateral septal complex100
100
Actr1bMBMidbrain100
100
Actr1bMYMedulla100
100
Actr1bOLFOlfactory bulb100
100
Actr1bPPons96.97
100
Actr1bPALPallidum100
100
Actr1bRHPRetrohippocampal region100
100
Actr1bsAMYStriatum-like amygdalar nuclei100
100
Actr1bSTRStriatum100
100
Actr1bSTRdStriatum dorsal region100
100
Actr1bSTRvStriatum ventral region100
100
Actr1bTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ACTY_HUMAN_152 30 152 181 TTGVVLDSGDGVTHAVPIYEGFAMPHSIMR PRIDE
ACTY_HUMAN_320 5 320 324 KLAPK PRIDE
ACTY_HUMAN_336 19 336 354 LYSTWIGGSILASLDTFKK PRIDE
ACTY_HUMAN_46 15 46 60 VMAGALEGDLFIGPK PRIDE
ACTY_HUMAN_73 9 73 81 YPMEHGVVR PRIDE
ACTY_HUMAN_82 7 82 88 DWNDMER PRIDE
PAp00007990 30 153 182 TTGVVLDSGDGVTHAVPIYEGFAMPHSIMR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved