AutismKB 2.0

Annotation Detail for RASGRP1


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Basic Information Top
Gene Symbol:RASGRP1 ( CALDAG-GEFI,CALDAG-GEFII,MGC129998,MGC129999,RASGRP,V,hRasGRP1 )
Gene Full Name: RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Band: 15q14
Quick LinksEntrez ID:10125; OMIM: 603962; Uniprot ID:GRP1_HUMAN; ENSEMBL ID: ENSG00000172575; HGNC ID: 9878
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal106 / 336030731
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain40 / 110098936
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine1 / 2344724
kidney3 / 21177714
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph1 / 4427022
lymph node23 / 91610251
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen4 / 5395274
stomach2 / 9661920
testis3 / 3304429
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205590_at
Cell line Expression level Expression bar
721_B_lymphoblasts125.8
Adipocyte5.5
AdrenalCortex6.15
Adrenalgland4.75
Amygdala68.9
Appendix6.15
AtrioventricularNode4.7
BDCA4+_DentriticCells48.45
Bonemarrow5.6
BronchialEpithelialCells5.55
CD105+_Endothelial6.25
CD14+_Monocytes6.05
CD19+_BCells(neg._sel.)206.7
CD33+_Myeloid7.15
CD34+7
CD4+_Tcells1018.8
CD56+_NKCells689.75
CD71+_EarlyErythroid5.35
CD8+_Tcells989.4
CardiacMyocytes7.8
Caudatenucleus40.8
Cerebellum19.6
CerebellumPeduncles42.25
CiliaryGanglion4.25
CingulateCortex25.7
Colorectaladenocarcinoma5.6
DorsalRootGanglion4.5
FetalThyroid5.8
Fetalbrain7.25
Fetalliver4.85
Fetallung4.6
GlobusPallidus6.85
Heart7.7
Hypothalamus7
Kidney4.6
Leukemia_chronicMyelogenousK-5625
Leukemia_promyelocytic-HL-6031.7
Leukemialymphoblastic(MOLT-4)70.45
Liver7.6
Lung6.15
Lymphnode103.15
Lymphoma_burkitts(Daudi)10.15
Lymphoma_burkitts(Raji)64.7
MedullaOblongata5.5
OccipitalLobe23.45
OlfactoryBulb4.35
Ovary3.8
Pancreas4.55
PancreaticIslet6.05
ParietalLobe6.5
Pituitary6.5
Placenta6.1
Pons5.75
PrefrontalCortex53.7
Prostate6.55
Salivarygland4.8
SkeletalMuscle7
Skin4.65
SmoothMuscle6.4
Spinalcord6.1
SubthalamicNucleus6.3
SuperiorCervicalGanglion6.9
TemporalLobe6
Testis4.85
TestisGermCell4.55
TestisIntersitial4.7
TestisLeydigCell5.6
TestisSeminiferousTubule4.9
Thalamus15.05
Thymus42.55
Thyroid6.8
Tongue5.7
Tonsil20.45
Trachea4.7
TrigeminalGanglion5.9
Uterus4.55
UterusCorpus5.1
WholeBlood276.85
Wholebrain20.55
colon5.6
pineal_day6.84
pineal_night6.78
retina6.725
small_intestine5.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P113258
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.52 ± 0.72
Basal Forebrain6.67 ± 0.78
Basal Part of Pons8.26 ± 0.33
Cerebellar Cortex6.74 ± 0.18
Cerebellar Nuclei5.06 ± 0.72
Claustrum8.07 ± 0.32
Epithalamus5.92 ± 1.15
Frontal Lobe6.78 ± 0.62
Globus Pallidus2.87 ± 1.51
Hypothalamus5.32 ± 0.81
Insula6.6 ± 0.35
Limbic Lobe6.71 ± 0.87
Mesencephalon5.63 ± 0.98
Myelencephalon6.32 ± 1.07
Occipital Lobe5.62 ± 1.01
Parietal Lobe6.29 ± 0.71
Pontine Tegmentum5.99 ± 0.75
Striatum6.69 ± 0.78
Subthalamus5.12 ± 0.58
Temporal Lobe6.4 ± 0.66
Thalamus6.65 ± 0.79
White Matter3.62 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rasgrp1CBCerebellum66.92
72.12
Rasgrp1CTXCerebral cortex100
100
Rasgrp1HIPHippocampal region93.43
100
Rasgrp1HPFHippocampal formation100
100
Rasgrp1HYHypothalamus54.23
53.36
Rasgrp1LSXLateral septal complex64.13
60.11
Rasgrp1MBMidbrain55.19
54.24
Rasgrp1MYMedulla58.36
57.97
Rasgrp1OLFOlfactory bulb100
100
Rasgrp1PPons55.08
54.55
Rasgrp1PALPallidum61.76
61.77
Rasgrp1RHPRetrohippocampal region100
100
Rasgrp1sAMYStriatum-like amygdalar nuclei89.94
85.44
Rasgrp1STRStriatum100
100
Rasgrp1STRdStriatum dorsal region100
100
Rasgrp1STRvStriatum ventral region95.57
90.57
Rasgrp1THThalamus81.2
84.64
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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