AutismKB 2.0

Annotation Detail for DNAL4


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Basic Information Top
Gene Symbol:DNAL4 ( PIG27 )
Gene Full Name: dynein, axonemal, light chain 4
Band: 22q13.1
Quick LinksEntrez ID:10126; OMIM: 610565; Uniprot ID:DNAL4_HUMAN; ENSEMBL ID: ENSG00000100246; HGNC ID: 2955
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus34 / 56401260
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult45 / 193912123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor2 / 2638457
glioma7 / 10688365
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal122 / 336030736
ovarian tumor3 / 7668239
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer1 / 1026809
retinoblastoma3 / 4635664
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow1 / 4880120
brain60 / 110098954
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus1 / 2020949
eye11 / 21105452
heart4 / 8962644
intestine6 / 23447225
kidney7 / 21177733
larynx0 / 241450 
liver1 / 2077434
lung14 / 33697441
lymph0 / 442700 
lymph node2 / 9161021
mammary gland2 / 15327113
mouth0 / 670520 
muscle2 / 10771518
nerve1 / 1576863
ovary7 / 10205168
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate1 / 1893455
salivary gland0 / 201550 
skin5 / 21057423
spleen2 / 5395237
stomach0 / 966190 
testis22 / 33044266
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204008_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.95
Adipocyte4.85
AdrenalCortex4.95
Adrenalgland4.3
Amygdala7.25
Appendix4.85
AtrioventricularNode3.7
BDCA4+_DentriticCells5.6
Bonemarrow4.85
BronchialEpithelialCells4.95
CD105+_Endothelial5
CD14+_Monocytes5.3
CD19+_BCells(neg._sel.)5.65
CD33+_Myeloid6.35
CD34+6.25
CD4+_Tcells5.4
CD56+_NKCells6.55
CD71+_EarlyErythroid4.6
CD8+_Tcells4.8
CardiacMyocytes6.15
Caudatenucleus4.4
Cerebellum4
CerebellumPeduncles5.55
CiliaryGanglion3.4
CingulateCortex5
Colorectaladenocarcinoma4.9
DorsalRootGanglion3.7
FetalThyroid4.85
Fetalbrain4.95
Fetalliver4.15
Fetallung4.15
GlobusPallidus3.6
Heart6.65
Hypothalamus5.4
Kidney4
Leukemia_chronicMyelogenousK-5624.45
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)4
Liver6.4
Lung5.5
Lymphnode4.1
Lymphoma_burkitts(Daudi)6.25
Lymphoma_burkitts(Raji)6.8
MedullaOblongata4.5
OccipitalLobe4.45
OlfactoryBulb3.8
Ovary3.25
Pancreas3.9
PancreaticIslet5.25
ParietalLobe5.1
Pituitary6.1
Placenta5
Pons4.6
PrefrontalCortex6.25
Prostate6.6
Salivarygland3.9
SkeletalMuscle5.95
Skin3.65
SmoothMuscle5.55
Spinalcord5.3
SubthalamicNucleus4.45
SuperiorCervicalGanglion5.45
TemporalLobe4.6
Testis24.65
TestisGermCell6.7
TestisIntersitial9.25
TestisLeydigCell5.55
TestisSeminiferousTubule4.3
Thalamus5
Thymus3.95
Thyroid11.75
Tongue4.75
Tonsil4.75
Trachea4.15
TrigeminalGanglion4.75
Uterus4.1
UterusCorpus4.35
WholeBlood5.4
Wholebrain10.45
colon4.95
pineal_day6.2
pineal_night6.08
retina6.05
small_intestine4.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10566_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.1 ± 0.83
Basal Forebrain3.04 ± 0.34
Basal Part of Pons3.14 ± 0.89
Cerebellar Cortex3.02 ± 0.65
Cerebellar Nuclei3.11 ± 0.56
Claustrum3.94 ± 0.9
Epithalamus3.22 ± 0.78
Frontal Lobe3.47 ± 0.73
Globus Pallidus3.09 ± 0.66
Hypothalamus3.39 ± 0.81
Insula3.64 ± 0.42
Limbic Lobe3.73 ± 0.78
Mesencephalon3.56 ± 0.76
Myelencephalon3.42 ± 0.77
Occipital Lobe3.19 ± 0.62
Parietal Lobe3.27 ± 0.77
Pontine Tegmentum3.54 ± 0.71
Striatum3.71 ± 0.73
Subthalamus3.21 ± 0.38
Temporal Lobe3.68 ± 0.77
Thalamus3.33 ± 0.73
White Matter2.26 ± 0.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dnalc4CBCerebellum46.99
74.28
Dnalc4CTXCerebral cortex100
100
Dnalc4HIPHippocampal region100
100
Dnalc4HPFHippocampal formation100
100
Dnalc4HYHypothalamus65.29
55.92
Dnalc4LSXLateral septal complex100
100
Dnalc4MBMidbrain75.4
71.14
Dnalc4MYMedulla44.2
47.07
Dnalc4OLFOlfactory bulb100
100
Dnalc4PPons58.41
59.65
Dnalc4PALPallidum58.46
53.73
Dnalc4RHPRetrohippocampal region100
100
Dnalc4sAMYStriatum-like amygdalar nuclei99.21
86.1
Dnalc4STRStriatum100
100
Dnalc4STRdStriatum dorsal region100
100
Dnalc4STRvStriatum ventral region100
100
Dnalc4THThalamus75.08
69.88
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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