AutismKB 2.0

Annotation Detail for SORBS3


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Basic Information Top
Gene Symbol:SORBS3 ( SCAM-1,SCAM1,SH3D4,VINEXIN )
Gene Full Name: sorbin and SH3 domain containing 3
Band: 8p21.3
Quick LinksEntrez ID:10174; OMIM: 610795; Uniprot ID:VINEX_HUMAN; ENSEMBL ID: ENSG00000120896; HGNC ID: 30907
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst3 / 6231948
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult172 / 193912188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma11 / 82823132
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor6 / 26384522
glioma17 / 106883159
head and neck tumor15 / 136302110
kidney tumor8 / 68959116
leukemia4 / 9584241
liver tumor7 / 9635972
lung tumor10 / 10312796
lymphoma8 / 71755111
non-neoplasia6 / 9725061
normal207 / 336030761
ovarian tumor11 / 76682143
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS19 / 125680151
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood6 / 12347848
bone7 / 7165597
bone marrow1 / 4880120
brain51 / 110098946
cervix2 / 4817141
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus1 / 2020949
eye20 / 21105494
heart4 / 8962644
intestine11 / 23447246
kidney17 / 21177780
larynx2 / 2414582
liver9 / 20774343
lung27 / 33697480
lymph1 / 4427022
lymph node0 / 916100 
mammary gland6 / 15327139
mouth2 / 6705229
muscle1 / 1077159
nerve3 / 15768190
ovary15 / 102051146
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta22 / 28082578
prostate16 / 18934584
salivary gland10 / 20155496
skin8 / 21057437
spleen9 / 53952166
stomach1 / 9661910
testis17 / 33044251
thymus0 / 811310 
thyroid6 / 47473126
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus9 / 23287838
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207788_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.95
Adipocyte38.25
AdrenalCortex16.4
Adrenalgland13.15
Amygdala17.2
Appendix13.15
AtrioventricularNode8.8
BDCA4+_DentriticCells9.6
Bonemarrow11.85
BronchialEpithelialCells14.75
CD105+_Endothelial10.45
CD14+_Monocytes14.1
CD19+_BCells(neg._sel.)10.9
CD33+_Myeloid14.25
CD34+5.9
CD4+_Tcells10.35
CD56+_NKCells10.2
CD71+_EarlyErythroid6.9
CD8+_Tcells8.75
CardiacMyocytes66.6
Caudatenucleus12.3
Cerebellum17.7
CerebellumPeduncles26.35
CiliaryGanglion9.25
CingulateCortex13.8
Colorectaladenocarcinoma33.15
DorsalRootGanglion9.2
FetalThyroid19.15
Fetalbrain13
Fetalliver13.1
Fetallung14.75
GlobusPallidus9.5
Heart17.95
Hypothalamus16.05
Kidney33.25
Leukemia_chronicMyelogenousK-56211.5
Leukemia_promyelocytic-HL-6011.05
Leukemialymphoblastic(MOLT-4)28.9
Liver36.15
Lung24.45
Lymphnode11.7
Lymphoma_burkitts(Daudi)17.25
Lymphoma_burkitts(Raji)16.9
MedullaOblongata11.95
OccipitalLobe11.65
OlfactoryBulb10.75
Ovary20.45
Pancreas9.2
PancreaticIslet14
ParietalLobe19.75
Pituitary15.85
Placenta14.9
Pons19.95
PrefrontalCortex23.4
Prostate25.6
Salivarygland9.3
SkeletalMuscle38.6
Skin10.1
SmoothMuscle62
Spinalcord15.65
SubthalamicNucleus12.6
SuperiorCervicalGanglion15.6
TemporalLobe15.05
Testis15.65
TestisGermCell29.2
TestisIntersitial33.85
TestisLeydigCell15.65
TestisSeminiferousTubule24.3
Thalamus13.3
Thymus9.55
Thyroid86.05
Tongue19.75
Tonsil13.05
Trachea13.85
TrigeminalGanglion12.35
Uterus22.05
UterusCorpus27.15
WholeBlood11.8
Wholebrain10.85
colon13.25
pineal_day14.64
pineal_night13.24
retina43.1
small_intestine11.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16831_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.39 ± 0.56
Basal Forebrain5.27 ± 0.23
Basal Part of Pons5.2 ± 0.41
Cerebellar Cortex5.23 ± 0.37
Cerebellar Nuclei5.47 ± 0.45
Claustrum5.71 ± 0.53
Epithalamus4.75 ± 0.39
Frontal Lobe5.11 ± 0.43
Globus Pallidus5.71 ± 0.38
Hypothalamus5.19 ± 0.41
Insula5.05 ± 0.32
Limbic Lobe5.23 ± 0.46
Mesencephalon5.35 ± 0.41
Myelencephalon5.3 ± 0.48
Occipital Lobe5.36 ± 0.47
Parietal Lobe5.23 ± 0.44
Pontine Tegmentum5.11 ± 0.41
Striatum5.33 ± 0.58
Subthalamus5.07 ± 0.94
Temporal Lobe5.14 ± 0.45
Thalamus5.38 ± 0.35
White Matter5.63 ± 0.18
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00137533 13 364 376 DPSASNGGGSPAR Peptide Atlas
VINEX_HUMAN_550 15 550 564 SPADPTDLGGQTSPR PRIDE
VINEX_HUMAN_578 17 578 594 PQTQNLGTPGPALSHSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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