AutismKB 2.0

Annotation Detail for TNK2


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Basic Information Top
Gene Symbol:TNK2 ( ACK,ACK1,FLJ44758,FLJ45547,p21cdc42Hs )
Gene Full Name: tyrosine kinase, non-receptor, 2
Band: 3q29
Quick LinksEntrez ID:10188; OMIM: 606994; Uniprot ID:ACK1_HUMAN; ENSEMBL ID: ENSG00000061938; HGNC ID: 19297
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst6 / 6231996
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult90 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma0 / 828230 
colorectal tumor7 / 11424661
esophageal tumor4 / 17290231
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma39 / 106883364
head and neck tumor8 / 13630258
kidney tumor2 / 6895929
leukemia14 / 95842146
liver tumor2 / 9635920
lung tumor6 / 10312758
lymphoma7 / 7175597
non-neoplasia2 / 9725020
normal159 / 336030747
ovarian tumor2 / 7668226
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer11 / 102680107
retinoblastoma1 / 4635621
skin tumor10 / 12494980
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood6 / 12347848
bone0 / 716550 
bone marrow3 / 4880161
brain99 / 110098989
cervix2 / 4817141
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus4 / 20209197
eye6 / 21105428
heart2 / 8962622
intestine7 / 23447229
kidney6 / 21177728
larynx5 / 24145207
liver2 / 2077439
lung15 / 33697444
lymph3 / 4427067
lymph node19 / 91610207
mammary gland6 / 15327139
mouth2 / 6705229
muscle1 / 1077159
nerve4 / 15768253
ovary2 / 10205119
pancreas18 / 21481283
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate16 / 18934584
salivary gland2 / 2015599
skin11 / 21057452
spleen3 / 5395255
stomach4 / 9661941
testis6 / 33044218
thymus7 / 8113186
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203839_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts99.25
Adipocyte33.2
AdrenalCortex40.25
Adrenalgland23.5
Amygdala222.55
Appendix36.85
AtrioventricularNode24.8
BDCA4+_DentriticCells209.35
Bonemarrow41.95
BronchialEpithelialCells26
CD105+_Endothelial108.8
CD14+_Monocytes283.25
CD19+_BCells(neg._sel.)246.7
CD33+_Myeloid305.7
CD34+309
CD4+_Tcells262.45
CD56+_NKCells145.7
CD71+_EarlyErythroid177.85
CD8+_Tcells218.55
CardiacMyocytes81.75
Caudatenucleus152.9
Cerebellum42.35
CerebellumPeduncles77.1
CiliaryGanglion23.2
CingulateCortex186.75
Colorectaladenocarcinoma430.45
DorsalRootGanglion23.6
FetalThyroid27.95
Fetalbrain64.45
Fetalliver31.8
Fetallung31.45
GlobusPallidus69.8
Heart54.55
Hypothalamus163.35
Kidney23.3
Leukemia_chronicMyelogenousK-56230.15
Leukemia_promyelocytic-HL-6031.5
Leukemialymphoblastic(MOLT-4)33.8
Liver38.1
Lung36.55
Lymphnode84.15
Lymphoma_burkitts(Daudi)53.7
Lymphoma_burkitts(Raji)105.05
MedullaOblongata68.4
OccipitalLobe82.7
OlfactoryBulb45.7
Ovary24.35
Pancreas29.65
PancreaticIslet30.25
ParietalLobe62.45
Pituitary46.55
Placenta31.2
Pons69.65
PrefrontalCortex373.05
Prostate62.2
Salivarygland33.75
SkeletalMuscle50.8
Skin32.7
SmoothMuscle26.25
Spinalcord98.65
SubthalamicNucleus108.85
SuperiorCervicalGanglion33.45
TemporalLobe70.85
Testis26.85
TestisGermCell39
TestisIntersitial26.8
TestisLeydigCell32.6
TestisSeminiferousTubule29.9
Thalamus109.05
Thymus27.05
Thyroid57.05
Tongue35.75
Tonsil54.05
Trachea24.5
TrigeminalGanglion35.85
Uterus30.5
UterusCorpus27.8
WholeBlood80.35
Wholebrain108.35
colon38.75
pineal_day233.42
pineal_night186.4
retina69.25
small_intestine36.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P180741
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.66 ± 0.57
Basal Forebrain6.56 ± 0.27
Basal Part of Pons6.2 ± 0.66
Cerebellar Cortex5.75 ± 0.3
Cerebellar Nuclei6.14 ± 0.29
Claustrum6.95 ± 0.75
Epithalamus5.18 ± 0.58
Frontal Lobe5.93 ± 0.54
Globus Pallidus6.85 ± 0.24
Hypothalamus5.83 ± 0.73
Insula6.01 ± 0.59
Limbic Lobe6.28 ± 0.66
Mesencephalon6.35 ± 0.56
Myelencephalon6.27 ± 0.6
Occipital Lobe6.63 ± 0.64
Parietal Lobe6.29 ± 0.59
Pontine Tegmentum6.11 ± 0.55
Striatum6.73 ± 0.62
Subthalamus5.9 ± 0.42
Temporal Lobe6.07 ± 0.53
Thalamus6.12 ± 0.52
White Matter6.18 ± 0.69
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnk2CBCerebellum4.59
5.5
Tnk2CTXCerebral cortex16.24
11.05
Tnk2HIPHippocampal region13.07
13.18
Tnk2HPFHippocampal formation12.74
11.4
Tnk2HYHypothalamus4.79
3.76
Tnk2LSXLateral septal complex0.96
0.67
Tnk2MBMidbrain6.69
6.6
Tnk2MYMedulla16.04
20.06
Tnk2OLFOlfactory bulb14.15
9.78
Tnk2PPons13.27
15.1
Tnk2PALPallidum5.43
4.92
Tnk2RHPRetrohippocampal region12.55
9.12
Tnk2sAMYStriatum-like amygdalar nuclei7.35
4.81
Tnk2STRStriatum3.42
2.42
Tnk2STRdStriatum dorsal region2.79
2
Tnk2STRvStriatum ventral region4.86
3.39
Tnk2THThalamus3.29
2.85
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ACK1_HUMAN_1004 31 1004 1034 GECHKVLEMFDWNLEQAGCHLLGSWGPAHHK PRIDE
ACK1_HUMAN_349 33 349 381 LPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALR PRIDE
PAp01144158 11 192 202 LYGVVLTPPMK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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