Annotation Detail for ADAM10
Basic Information Top
| Gene Symbol: | ADAM10 ( AD10,CD156c,HsT18717,MADM,kuz ) |
|---|---|
| Gene Full Name: | ADAM metallopeptidase domain 10 |
| Band: | 15q21.3 |
| Quick Links | Entrez ID:102; OMIM: 602192; Uniprot ID:ADA10_HUMAN; ENSEMBL ID: ENSG00000137845; HGNC ID: 188 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.578508
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 5 / 70761 | 70 |  |
| blastocyst | 6 / 62319 | 96 | |
| fetus | 66 / 564012 | 117 | |
| neonate | 3 / 31097 | 96 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 15 / 55556 | 269 |  |
| adult | 103 / 1939121 | 53 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 3 / 17475 | 171 | |
| breast (mammary gland) tumor | 4 / 94178 | 42 |  |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 4 / 82823 | 48 | |
| colorectal tumor | 7 / 114246 | 61 | |
| esophageal tumor | 3 / 17290 | 173 | |
| gastrointestinal tumor | 11 / 119369 | 92 | |
| germ cell tumor | 16 / 263845 | 60 | |
| glioma | 1 / 106883 | 9 |  |
| head and neck tumor | 15 / 136302 | 110 | |
| kidney tumor | 3 / 68959 | 43 | |
| leukemia | 1 / 95842 | 10 | |
| liver tumor | 15 / 96359 | 155 | |
| lung tumor | 1 / 103127 | 9 | |
| lymphoma | 2 / 71755 | 27 | |
| non-neoplasia | 4 / 97250 | 41 | |
| normal | 225 / 3360307 | 66 | |
| ovarian tumor | 2 / 76682 | 26 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 4 / 125680 | 31 | |
| prostate cancer | 4 / 102680 | 38 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 5 / 124949 | 40 | |
| soft tissue/muscle tissue tumor | 3 / 125191 | 23 | |
| uterine tumor | 4 / 90257 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 10 / 40015 | 249 | |
| bladder | 2 / 29757 | 67 | |
| blood | 2 / 123478 | 16 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 65 / 1100989 | 59 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 9 / 149255 | 60 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 15 / 215722 | 69 | |
| esophagus | 3 / 20209 | 148 | |
| eye | 7 / 211054 | 33 | |
| heart | 3 / 89626 | 33 | |
| intestine | 12 / 234472 | 51 | |
| kidney | 5 / 211777 | 23 | |
| larynx | 1 / 24145 | 41 | |
| liver | 17 / 207743 | 81 | |
| lung | 6 / 336974 | 17 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 1 / 91610 | 10 | |
| mammary gland | 6 / 153271 | 39 | |
| mouth | 11 / 67052 | 164 | |
| muscle | 13 / 107715 | 120 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 5 / 102051 | 48 | |
| pancreas | 2 / 214812 | 9 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 26 / 280825 | 92 | |
| prostate | 7 / 189345 | 36 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 16 / 210574 | 75 | |
| spleen | 3 / 53952 | 55 | |
| stomach | 1 / 96619 | 10 | |
| testis | 24 / 330442 | 72 | |
| thymus | 22 / 81131 | 271 | |
| thyroid | 4 / 47473 | 84 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 15 / 52413 | 286 | |
| umbilical cord | 1 / 13680 | 73 | |
| uterus | 13 / 232878 | 55 | |
| vascular | 13 / 51780 | 251 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 202604_x_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 7.5 | |
| Adipocyte | 5 | |
| AdrenalCortex | 5.45 | |
| Adrenalgland | 4.2 | |
| Amygdala | 5.2 | |
| Appendix | 5.05 | |
| AtrioventricularNode | 3.85 | |
| BDCA4+_DentriticCells | 22.85 | |
| Bonemarrow | 4.95 | |
| BronchialEpithelialCells | 7 | |
| CD105+_Endothelial | 4.95 | |
| CD14+_Monocytes | 25.9 | |
| CD19+_BCells(neg._sel.) | 5.35 | |
| CD33+_Myeloid | 41.55 | |
| CD34+ | 7.75 | |
| CD4+_Tcells | 6.55 | |
| CD56+_NKCells | 43.85 | |
| CD71+_EarlyErythroid | 4.6 | |
| CD8+_Tcells | 8.55 | |
| CardiacMyocytes | 34.3 | |
| Caudatenucleus | 4.55 | |
| Cerebellum | 4.1 | |
| CerebellumPeduncles | 5.75 | |
| CiliaryGanglion | 3.7 | |
| CingulateCortex | 5.1 | |
| Colorectaladenocarcinoma | 5 | |
| DorsalRootGanglion | 5 | |
| FetalThyroid | 5 | |
| Fetalbrain | 4.95 | |
| Fetalliver | 4.3 | |
| Fetallung | 4.3 | |
| GlobusPallidus | 3.7 | |
| Heart | 6.7 | |
| Hypothalamus | 5.35 | |
| Kidney | 4.15 | |
| Leukemia_chronicMyelogenousK-562 | 4.55 | |
| Leukemia_promyelocytic-HL-60 | 4.4 | |
| Leukemialymphoblastic(MOLT-4) | 4.8 | |
| Liver | 6.65 | |
| Lung | 5.35 | |
| Lymphnode | 4.35 | |
| Lymphoma_burkitts(Daudi) | 6.35 | |
| Lymphoma_burkitts(Raji) | 7 | |
| MedullaOblongata | 4.7 | |
| OccipitalLobe | 4.4 | |
| OlfactoryBulb | 4.05 | |
| Ovary | 3.3 | |
| Pancreas | 4.1 | |
| PancreaticIslet | 5.3 | |
| ParietalLobe | 5.35 | |
| Pituitary | 5.85 | |
| Placenta | 5.5 | |
| Pons | 4.75 | |
| PrefrontalCortex | 6.1 | |
| Prostate | 5.75 | |
| Salivarygland | 4 | |
| SkeletalMuscle | 6.05 | |
| Skin | 3.9 | |
| SmoothMuscle | 18.35 | |
| Spinalcord | 5.3 | |
| SubthalamicNucleus | 4.6 | |
| SuperiorCervicalGanglion | 5.8 | |
| TemporalLobe | 4.6 | |
| Testis | 4.25 | |
| TestisGermCell | 4 | |
| TestisIntersitial | 4.2 | |
| TestisLeydigCell | 4.95 | |
| TestisSeminiferousTubule | 4.25 | |
| Thalamus | 5.1 | |
| Thymus | 3.8 | |
| Thyroid | 6.25 | |
| Tongue | 4.95 | |
| Tonsil | 4.9 | |
| Trachea | 4.2 | |
| TrigeminalGanglion | 5 | |
| Uterus | 4.1 | |
| UterusCorpus | 4.5 | |
| WholeBlood | 14.75 | |
| Wholebrain | 4.15 | |
| colon | 5.05 | |
| pineal_day | 6.2 | |
| pineal_night | 6.08 | |
| retina | 6.025 | |
| small_intestine | 4.8 | |
- Probe name: A_23_P48886
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.1 ± 0.46 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.08 ± 0.2 | |
| Basal Part of Pons | 4.87 ± 0.48 | |
| Cerebellar Cortex | 5.52 ± 0.29 | |
| Cerebellar Nuclei | 5.51 ± 0.53 | |
| Claustrum | 5.37 ± 0.41 | |
| Epithalamus | 5.4 ± 0.35 | |
| Frontal Lobe | 5.13 ± 0.43 | |
| Globus Pallidus | 5.59 ± 0.42 | |
| Hypothalamus | 4.68 ± 0.47 | |
| Insula | 5.23 ± 0.42 | |
| Limbic Lobe | 5.18 ± 0.44 | |
| Mesencephalon | 5.23 ± 0.45 | |
| Myelencephalon | 5.23 ± 0.45 | |
| Occipital Lobe | 5.44 ± 0.4 | |
| Parietal Lobe | 5.14 ± 0.42 | |
| Pontine Tegmentum | 5.34 ± 0.46 | |
| Striatum | 5.32 ± 0.38 | |
| Subthalamus | 5.22 ± 0.44 | |
| Temporal Lobe | 5.17 ± 0.35 | |
| Thalamus | 5.4 ± 0.41 | |
| White Matter | 6.43 ± 0.24 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Adam10 | CB | Cerebellum | 44.36 | |
| 51.45 | | |||
| Adam10 | CTX | Cerebral cortex | 92.65 | |
| 76.06 | | |||
| Adam10 | HIP | Hippocampal region | 38.78 | |
| 59.44 | | |||
| Adam10 | HPF | Hippocampal formation | 47.32 | |
| 57.91 | | |||
| Adam10 | HY | Hypothalamus | 24.78 | |
| 20.53 | | |||
| Adam10 | LSX | Lateral septal complex | 51.55 | |
| 45.03 | | |||
| Adam10 | MB | Midbrain | 20.82 | |
| 17.82 | | |||
| Adam10 | MY | Medulla | 20.7 | |
| 20.37 | | |||
| Adam10 | OLF | Olfactory bulb | 62.13 | |
| 56.53 | | |||
| Adam10 | P | Pons | 18.26 | |
| 16.87 | | |||
| Adam10 | PAL | Pallidum | 18.59 | |
| 15.75 | | |||
| Adam10 | RHP | Retrohippocampal region | 63.05 | |
| 57.23 | | |||
| Adam10 | sAMY | Striatum-like amygdalar nuclei | 33.27 | |
| 25.85 | | |||
| Adam10 | STR | Striatum | 29.95 | |
| 23.1 | | |||
| Adam10 | STRd | Striatum dorsal region | 28.28 | |
| 21.66 | | |||
| Adam10 | STRv | Striatum ventral region | 25.6 | |
| 18.05 | | |||
| Adam10 | TH | Thalamus | 21.29 | |
| 16.99 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00009796 | 25 | 322 | 346 | DFDDGVLGLAWVGAPSGSSGGICEK | Peptide Atlas |