AutismKB 2.0

Annotation Detail for CDK5


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Basic Information Top
Gene Symbol:CDK5 ( PSSALRE )
Gene Full Name: cyclin-dependent kinase 5
Band: 7q36.1
Quick LinksEntrez ID:1020; OMIM: 123831; Uniprot ID:CDK5_HUMAN; ENSEMBL ID: ENSG00000164885; HGNC ID: 1774
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult35 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor2 / 2638457
glioma5 / 10688346
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal71 / 336030721
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer6 / 10268058
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites2 / 4001549
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow4 / 4880181
brain57 / 110098951
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye9 / 21105442
heart2 / 8962622
intestine1 / 2344724
kidney6 / 21177728
larynx0 / 241450 
liver4 / 20774319
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary4 / 10205139
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate9 / 18934547
salivary gland1 / 2015549
skin5 / 21057423
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus0 / 811310 
thyroid2 / 4747342
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204247_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts58
Adipocyte32.4
AdrenalCortex19.55
Adrenalgland16.5
Amygdala115.3
Appendix19.4
AtrioventricularNode14.7
BDCA4+_DentriticCells30.35
Bonemarrow19.6
BronchialEpithelialCells19.4
CD105+_Endothelial17.45
CD14+_Monocytes32.25
CD19+_BCells(neg._sel.)15.05
CD33+_Myeloid27.15
CD34+24.85
CD4+_Tcells20
CD56+_NKCells24
CD71+_EarlyErythroid17.05
CD8+_Tcells14.95
CardiacMyocytes27.35
Caudatenucleus51.75
Cerebellum48.9
CerebellumPeduncles54.1
CiliaryGanglion12.25
CingulateCortex65.3
Colorectaladenocarcinoma19.3
DorsalRootGanglion13.15
FetalThyroid20
Fetalbrain53.45
Fetalliver14.75
Fetallung14.25
GlobusPallidus23.25
Heart25.3
Hypothalamus79.25
Kidney16.1
Leukemia_chronicMyelogenousK-56217.8
Leukemia_promyelocytic-HL-6017.2
Leukemialymphoblastic(MOLT-4)41
Liver39.2
Lung28.4
Lymphnode15.7
Lymphoma_burkitts(Daudi)25.25
Lymphoma_burkitts(Raji)36.25
MedullaOblongata81.85
OccipitalLobe57.1
OlfactoryBulb14
Ovary12.65
Pancreas15.25
PancreaticIslet20.2
ParietalLobe87.15
Pituitary26.35
Placenta17.55
Pons34.05
PrefrontalCortex73.15
Prostate22.25
Salivarygland15.5
SkeletalMuscle32.15
Skin14.5
SmoothMuscle22.85
Spinalcord34.4
SubthalamicNucleus65
SuperiorCervicalGanglion22.45
TemporalLobe95.05
Testis17.15
TestisGermCell12.85
TestisIntersitial12.05
TestisLeydigCell18.95
TestisSeminiferousTubule15.7
Thalamus55.3
Thymus17.1
Thyroid24.75
Tongue17.45
Tonsil19.05
Trachea15.4
TrigeminalGanglion19.3
Uterus14.45
UterusCorpus17.6
WholeBlood20.8
Wholebrain439.1
colon17.8
pineal_day52.28
pineal_night69.02
retina23.5
small_intestine18.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15042_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.88 ± 0.65
Basal Forebrain5.47 ± 0.82
Basal Part of Pons6.67 ± 0.63
Cerebellar Cortex6.08 ± 0.55
Cerebellar Nuclei6.1 ± 0.62
Claustrum5.35 ± 0.71
Epithalamus5.76 ± 0.64
Frontal Lobe6.35 ± 0.62
Globus Pallidus4.28 ± 0.71
Hypothalamus6.31 ± 0.52
Insula6.37 ± 0.43
Limbic Lobe5.9 ± 0.97
Mesencephalon5.67 ± 0.73
Myelencephalon5.84 ± 0.91
Occipital Lobe5.02 ± 0.98
Parietal Lobe5.96 ± 0.69
Pontine Tegmentum5.92 ± 0.67
Striatum5.12 ± 0.87
Subthalamus6.12 ± 0.87
Temporal Lobe6.31 ± 0.63
Thalamus5.75 ± 0.57
White Matter4.15 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cdk5CBCerebellum44.6
50
Cdk5CTXCerebral cortex50
50
Cdk5HIPHippocampal region50
50
Cdk5HPFHippocampal formation50
50
Cdk5HYHypothalamus50
50
Cdk5LSXLateral septal complex50
50
Cdk5MBMidbrain50
50
Cdk5MYMedulla50
50
Cdk5OLFOlfactory bulb50
50
Cdk5PPons50
50
Cdk5PALPallidum50
50
Cdk5RHPRetrohippocampal region50
50
Cdk5sAMYStriatum-like amygdalar nuclei50
50
Cdk5STRStriatum50
50
Cdk5STRdStriatum dorsal region50
50
Cdk5STRvStriatum ventral region50
50
Cdk5THThalamus50
50
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CDK5_HUMAN_1 24 1 24 MQKYEKLEKIGEGTYGTVFKAKNR PRIDE
CDK5_HUMAN_201 14 201 214 PLFPGNDVDDQLKR PRIDE
PAp00466138 9 66 74 LHDVLHSDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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