AutismKB 2.0

Annotation Detail for CDK6


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CDK6 ( MGC59692,PLSTIRE )
Gene Full Name: cyclin-dependent kinase 6
Band: 7q21.2
Quick LinksEntrez ID:1021; OMIM: 603368; Uniprot ID:CDK6_HUMAN; ENSEMBL ID: ENSG00000105810; HGNC ID: 1777
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body24 / 70761339
blastocyst1 / 6231916
fetus75 / 564012132
neonate0 / 310970 
infant0 / 236200 
juvenile10 / 55556179
adult109 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor20 / 119369167
germ cell tumor65 / 263845246
glioma7 / 10688365
head and neck tumor12 / 13630288
kidney tumor6 / 6895987
leukemia15 / 95842156
liver tumor7 / 9635972
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia6 / 9725061
normal264 / 336030778
ovarian tumor2 / 7668226
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor8 / 12494964
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites3 / 4001574
bladder1 / 2975733
blood14 / 123478113
bone4 / 7165555
bone marrow9 / 48801184
brain34 / 110098930
cervix0 / 481710 
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue30 / 215722139
esophagus1 / 2020949
eye10 / 21105447
heart8 / 8962689
intestine17 / 23447272
kidney18 / 21177784
larynx2 / 2414582
liver19 / 20774391
lung23 / 33697468
lymph1 / 4427022
lymph node21 / 91610229
mammary gland8 / 15327152
mouth8 / 67052119
muscle8 / 10771574
nerve0 / 157680 
ovary2 / 10205119
pancreas9 / 21481241
parathyroid6 / 20539292
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate4 / 18934521
salivary gland2 / 2015599
skin22 / 210574104
spleen0 / 539520 
stomach22 / 96619227
testis16 / 33044248
thymus18 / 81131221
thyroid0 / 474730 
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord0 / 136800 
uterus3 / 23287812
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207143_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.8
Adipocyte4.55
AdrenalCortex4.85
Adrenalgland3.9
Amygdala4.85
Appendix4.7
AtrioventricularNode3.6
BDCA4+_DentriticCells4.9
Bonemarrow4.55
BronchialEpithelialCells4.6
CD105+_Endothelial4.7
CD14+_Monocytes4.85
CD19+_BCells(neg._sel.)4.8
CD33+_Myeloid6
CD34+9.05
CD4+_Tcells5
CD56+_NKCells5.4
CD71+_EarlyErythroid4.25
CD8+_Tcells4.45
CardiacMyocytes6.3
Caudatenucleus4.1
Cerebellum3.75
CerebellumPeduncles5.2
CiliaryGanglion3.25
CingulateCortex4.7
Colorectaladenocarcinoma4.6
DorsalRootGanglion3.55
FetalThyroid4.5
Fetalbrain4.55
Fetalliver4.1
Fetallung3.85
GlobusPallidus3.4
Heart6.25
Hypothalamus4.95
Kidney3.8
Leukemia_chronicMyelogenousK-5624.25
Leukemia_promyelocytic-HL-604.1
Leukemialymphoblastic(MOLT-4)3.7
Liver6.15
Lung5.05
Lymphnode3.95
Lymphoma_burkitts(Daudi)5.9
Lymphoma_burkitts(Raji)6.6
MedullaOblongata4.25
OccipitalLobe4.15
OlfactoryBulb3.6
Ovary3.05
Pancreas3.7
PancreaticIslet4.95
ParietalLobe5.05
Pituitary5.4
Placenta4.75
Pons4.4
PrefrontalCortex5.6
Prostate5.3
Salivarygland3.65
SkeletalMuscle5.55
Skin3.55
SmoothMuscle5.25
Spinalcord4.9
SubthalamicNucleus4.2
SuperiorCervicalGanglion5.4
TemporalLobe4.2
Testis4.05
TestisGermCell3.85
TestisIntersitial3.9
TestisLeydigCell4.6
TestisSeminiferousTubule3.95
Thalamus4.65
Thymus3.85
Thyroid5.8
Tongue4.5
Tonsil4.5
Trachea3.85
TrigeminalGanglion4.6
Uterus3.75
UterusCorpus4.15
WholeBlood5.05
Wholebrain3.95
colon4.6
pineal_day5.58
pineal_night5.5
retina5.5
small_intestine4.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P168651
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.07 ± 0.6
Basal Forebrain5.5 ± 0.46
Basal Part of Pons5.32 ± 0.6
Cerebellar Cortex4.78 ± 0.32
Cerebellar Nuclei5.9 ± 0.32
Claustrum5.15 ± 0.78
Epithalamus4.97 ± 0.6
Frontal Lobe5.2 ± 0.62
Globus Pallidus6.84 ± 0.31
Hypothalamus4.32 ± 1.02
Insula5.22 ± 0.53
Limbic Lobe5.45 ± 0.47
Mesencephalon5.37 ± 0.7
Myelencephalon5.39 ± 0.69
Occipital Lobe5.61 ± 0.47
Parietal Lobe5.32 ± 0.59
Pontine Tegmentum5.51 ± 0.72
Striatum6.44 ± 0.57
Subthalamus5.39 ± 0.61
Temporal Lobe5.22 ± 0.51
Thalamus5.66 ± 0.6
White Matter7.44 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cdk6CBCerebellum3.46
4.56
Cdk6CTXCerebral cortex2.92
2.09
Cdk6HIPHippocampal region2.09
1.9
Cdk6HPFHippocampal formation1.93
1.55
Cdk6HYHypothalamus0.06
0.05
Cdk6LSXLateral septal complex0.61
0.78
Cdk6MBMidbrain1.43
1.87
Cdk6MYMedulla3.56
4.4
Cdk6OLFOlfactory bulb3.68
3.13
Cdk6PPons0.88
0.8
Cdk6PALPallidum0.08
0.08
Cdk6RHPRetrohippocampal region1.76
1.14
Cdk6sAMYStriatum-like amygdalar nuclei0.14
0.11
Cdk6STRStriatum0.49
0.5
Cdk6STRdStriatum dorsal region0.52
0.53
Cdk6STRvStriatum ventral region0.34
0.35
Cdk6THThalamus1.35
1.14
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CDK6_HUMAN_1 8 1 8 MEKDGLCR PRIDE
CDK6_HUMAN_47 14 47 60 VQTGEEGMPLSTIR PRIDE
PAp00009200 18 9 26 ADQQYECVAEIGEGAYGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved