AutismKB 2.0

Annotation Detail for MSLN


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Basic Information Top
Gene Symbol:MSLN ( MPF,SMRP )
Gene Full Name: mesothelin
Band: 16p13.3
Quick LinksEntrez ID:10232; OMIM: 601051; Uniprot ID:MSLN_HUMAN; ENSEMBL ID: ENSG00000102854; HGNC ID: 7371
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor4 / 34366116
chondrosarcoma1 / 8282312
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor4 / 26384515
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal34 / 336030710
ovarian tumor22 / 76682286
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor28 / 90257310
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain3 / 11009892
cervix14 / 48171290
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine8 / 23447234
kidney0 / 2117770 
larynx0 / 241450 
liver2 / 2077439
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary32 / 102051313
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta20 / 28082571
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach4 / 9661941
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus30 / 232878128
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204885_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.25
Adipocyte6.45
AdrenalCortex7.65
Adrenalgland5.6
Amygdala6.45
Appendix6.9
AtrioventricularNode5.45
BDCA4+_DentriticCells6.5
Bonemarrow6.95
BronchialEpithelialCells6.25
CD105+_Endothelial6.3
CD14+_Monocytes6.85
CD19+_BCells(neg._sel.)6.75
CD33+_Myeloid7.95
CD34+7.7
CD4+_Tcells6.5
CD56+_NKCells7.15
CD71+_EarlyErythroid6.1
CD8+_Tcells5.9
CardiacMyocytes9.3
Caudatenucleus5.8
Cerebellum5.35
CerebellumPeduncles7.6
CiliaryGanglion4.95
CingulateCortex6.8
Colorectaladenocarcinoma10.45
DorsalRootGanglion5.3
FetalThyroid6.3
Fetalbrain6.25
Fetalliver5.65
Fetallung14.95
GlobusPallidus4.9
Heart9
Hypothalamus7
Kidney5.7
Leukemia_chronicMyelogenousK-5625.9
Leukemia_promyelocytic-HL-605.7
Leukemialymphoblastic(MOLT-4)5.15
Liver9
Lung159.15
Lymphnode5.45
Lymphoma_burkitts(Daudi)8.45
Lymphoma_burkitts(Raji)9.5
MedullaOblongata5.8
OccipitalLobe5.7
OlfactoryBulb5.1
Ovary4.6
Pancreas6.8
PancreaticIslet6.95
ParietalLobe7.05
Pituitary7.6
Placenta6.6
Pons6.3
PrefrontalCortex7.75
Prostate7.55
Salivarygland5.25
SkeletalMuscle8.95
Skin5.5
SmoothMuscle7.25
Spinalcord6.9
SubthalamicNucleus6.05
SuperiorCervicalGanglion8.1
TemporalLobe6.05
Testis5.6
TestisGermCell5.25
TestisIntersitial5.55
TestisLeydigCell6.55
TestisSeminiferousTubule5.55
Thalamus6.7
Thymus4.9
Thyroid7.85
Tongue6.6
Tonsil6.55
Trachea6.75
TrigeminalGanglion6.8
Uterus5.15
UterusCorpus6
WholeBlood6.95
Wholebrain5.25
colon6.35
pineal_day7.78
pineal_night7.74
retina7.725
small_intestine6.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14990_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.74 ± 0.65
Basal Forebrain4.33 ± 0.55
Basal Part of Pons4.46 ± 0.47
Cerebellar Cortex4.34 ± 0.53
Cerebellar Nuclei4.48 ± 0.47
Claustrum4.7 ± 0.74
Epithalamus3.46 ± 0.59
Frontal Lobe4.27 ± 0.54
Globus Pallidus4.32 ± 1.07
Hypothalamus4.18 ± 0.49
Insula4.12 ± 0.68
Limbic Lobe4.42 ± 0.59
Mesencephalon4.28 ± 0.58
Myelencephalon4.36 ± 0.62
Occipital Lobe4.48 ± 0.69
Parietal Lobe4.39 ± 0.6
Pontine Tegmentum4.24 ± 0.64
Striatum4.39 ± 0.59
Subthalamus4.01 ± 0.51
Temporal Lobe4.32 ± 0.67
Thalamus4.39 ± 0.58
White Matter3.88 ± 0.59
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MslnCBCerebellum0.87
1.56
MslnCTXCerebral cortex1.88
1.6
MslnHIPHippocampal region4.32
6.77
MslnHPFHippocampal formation2.95
4.08
MslnHYHypothalamus18.47
7.28
MslnLSXLateral septal complex8.23
2.53
MslnMBMidbrain0.49
0.34
MslnMYMedulla2.34
1.21
MslnOLFOlfactory bulb7.47
5.04
MslnPPons3.79
2.42
MslnPALPallidum7.41
3.03
MslnRHPRetrohippocampal region0.59
0.39
MslnsAMYStriatum-like amygdalar nuclei0.64
0.21
MslnSTRStriatum2.01
0.79
MslnSTRdStriatum dorsal region0.14
0.17
MslnSTRvStriatum ventral region6.84
2.45
MslnTHThalamus0.94
0.4
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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