AutismKB 2.0

Annotation Detail for DCAF7


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Basic Information Top
Gene Symbol:DCAF7 ( AN11,HAN11,SWAN-1,WDR68 )
Gene Full Name: DDB1 and CUL4 associated factor 7
Band: 17q23.3
Quick LinksEntrez ID:10238; OMIM: 605973; Uniprot ID:DCAF7_HUMAN; ENSEMBL ID: ENSG00000136485; HGNC ID: 30915
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body15 / 70761211
blastocyst9 / 62319144
fetus87 / 564012154
neonate0 / 310970 
infant4 / 23620169
juvenile10 / 55556179
adult217 / 1939121111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma2 / 17475114
breast (mammary gland) tumor20 / 94178212
cervical tumor6 / 34366174
chondrosarcoma9 / 82823108
colorectal tumor20 / 114246175
esophageal tumor1 / 1729057
gastrointestinal tumor8 / 11936967
germ cell tumor26 / 26384598
glioma14 / 106883130
head and neck tumor13 / 13630295
kidney tumor9 / 68959130
leukemia12 / 95842125
liver tumor12 / 96359124
lung tumor16 / 103127155
lymphoma6 / 7175583
non-neoplasia7 / 9725071
normal374 / 3360307111
ovarian tumor8 / 76682104
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS19 / 125680151
prostate cancer19 / 102680185
retinoblastoma18 / 46356388
skin tumor17 / 124949136
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland4 / 33197120
ascites1 / 4001524
bladder3 / 29757100
blood15 / 123478121
bone8 / 71655111
bone marrow3 / 4880161
brain91 / 110098982
cervix6 / 48171124
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue44 / 215722203
esophagus1 / 2020949
eye46 / 211054217
heart7 / 8962678
intestine38 / 234472162
kidney18 / 21177784
larynx3 / 24145124
liver17 / 20774381
lung54 / 336974160
lymph2 / 4427045
lymph node27 / 91610294
mammary gland24 / 153271156
mouth10 / 67052149
muscle10 / 10771592
nerve0 / 157680 
ovary12 / 102051117
pancreas32 / 214812148
parathyroid1 / 2053948
pharynx4 / 4132896
pituitary gland1 / 1658560
placenta33 / 280825117
prostate25 / 189345132
salivary gland0 / 201550 
skin22 / 210574104
spleen4 / 5395274
stomach10 / 96619103
testis22 / 33044266
thymus3 / 8113136
thyroid2 / 4747342
tonsil3 / 16999176
trachea2 / 5241338
umbilical cord2 / 13680146
uterus22 / 23287894
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221744_at
Cell line Expression level Expression bar
721_B_lymphoblasts138.35
Adipocyte40.9
AdrenalCortex57.15
Adrenalgland40.9
Amygdala48.9
Appendix44.75
AtrioventricularNode44.65
BDCA4+_DentriticCells66.9
Bonemarrow81.5
BronchialEpithelialCells49.3
CD105+_Endothelial125.6
CD14+_Monocytes172.7
CD19+_BCells(neg._sel.)81.4
CD33+_Myeloid158.75
CD34+110.85
CD4+_Tcells75.65
CD56+_NKCells125.2
CD71+_EarlyErythroid47
CD8+_Tcells97.65
CardiacMyocytes101.75
Caudatenucleus39.45
Cerebellum55.7
CerebellumPeduncles81.7
CiliaryGanglion47.25
CingulateCortex55.35
Colorectaladenocarcinoma139.6
DorsalRootGanglion38.5
FetalThyroid55.5
Fetalbrain57.95
Fetalliver38.5
Fetallung36.6
GlobusPallidus42.1
Heart85.15
Hypothalamus45.9
Kidney49.65
Leukemia_chronicMyelogenousK-56277.05
Leukemia_promyelocytic-HL-6046.95
Leukemialymphoblastic(MOLT-4)96.65
Liver92.1
Lung57.35
Lymphnode35.7
Lymphoma_burkitts(Daudi)89.9
Lymphoma_burkitts(Raji)78.9
MedullaOblongata38.55
OccipitalLobe45.55
OlfactoryBulb39.2
Ovary35.6
Pancreas52.05
PancreaticIslet44.85
ParietalLobe60.2
Pituitary57.6
Placenta48.8
Pons49.15
PrefrontalCortex45.85
Prostate78.55
Salivarygland52.65
SkeletalMuscle78.15
Skin47.05
SmoothMuscle55.65
Spinalcord38
SubthalamicNucleus46.65
SuperiorCervicalGanglion77.6
TemporalLobe42.5
Testis35
TestisGermCell44.45
TestisIntersitial38.85
TestisLeydigCell48.55
TestisSeminiferousTubule47.5
Thalamus55.7
Thymus60.95
Thyroid46.35
Tongue55.9
Tonsil69.8
Trachea42.1
TrigeminalGanglion61.6
Uterus33.55
UterusCorpus35.75
WholeBlood61.25
Wholebrain36.5
colon42.05
pineal_day106.4
pineal_night103.68
retina80.775
small_intestine40.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P422268
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.27 ± 0.43
Basal Forebrain5.36 ± 0.2
Basal Part of Pons5.21 ± 0.31
Cerebellar Cortex5.45 ± 0.33
Cerebellar Nuclei5.04 ± 0.56
Claustrum5.13 ± 0.65
Epithalamus5.28 ± 0.39
Frontal Lobe5.33 ± 0.36
Globus Pallidus5.47 ± 0.27
Hypothalamus5.28 ± 0.3
Insula5.33 ± 0.29
Limbic Lobe5.32 ± 0.35
Mesencephalon5.24 ± 0.37
Myelencephalon5.35 ± 0.33
Occipital Lobe5.11 ± 0.32
Parietal Lobe5.2 ± 0.35
Pontine Tegmentum5.3 ± 0.51
Striatum5.31 ± 0.3
Subthalamus5.12 ± 0.26
Temporal Lobe5.38 ± 0.3
Thalamus5.27 ± 0.42
White Matter5.62 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wdr68CBCerebellum18.9
26.49
Wdr68CTXCerebral cortex65.6
66.89
Wdr68HIPHippocampal region80.06
100
Wdr68HPFHippocampal formation84.27
100
Wdr68HYHypothalamus54.37
55.06
Wdr68LSXLateral septal complex7.2
6.92
Wdr68MBMidbrain23.2
24.81
Wdr68MYMedulla15.28
19.74
Wdr68OLFOlfactory bulb78.51
89.46
Wdr68PPons25.93
31.95
Wdr68PALPallidum38.95
45
Wdr68RHPRetrohippocampal region95.92
100
Wdr68sAMYStriatum-like amygdalar nuclei100
100
Wdr68STRStriatum44
39.75
Wdr68STRdStriatum dorsal region35.13
29.52
Wdr68STRvStriatum ventral region54.37
48.67
Wdr68THThalamus23.43
24.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00069537 19 208 226 HLEHSTIIYEDPQHHPLLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018