AutismKB 2.0

Annotation Detail for CDK8


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Basic Information Top
Gene Symbol:CDK8 ( K35,MGC126074,MGC126075 )
Gene Full Name: cyclin-dependent kinase 8
Band: 13q12.13
Quick LinksEntrez ID:1024; OMIM: 603184; Uniprot ID:CDK8_HUMAN; ENSEMBL ID: ENSG00000132964; HGNC ID: 1779
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus7 / 56401212
neonate1 / 3109732
infant4 / 23620169
juvenile0 / 555560 
adult28 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal51 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow1 / 4880120
brain19 / 110098917
cervix0 / 481710 
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye3 / 21105414
heart1 / 8962611
intestine3 / 23447212
kidney2 / 2117779
larynx1 / 2414541
liver2 / 2077439
lung8 / 33697423
lymph1 / 4427022
lymph node0 / 916100 
mammary gland4 / 15327126
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta6 / 28082521
prostate2 / 18934510
salivary gland3 / 20155148
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis5 / 33044215
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204831_at
Cell line Expression level Expression bar
721_B_lymphoblasts101.75
Adipocyte12
AdrenalCortex18.9
Adrenalgland11.85
Amygdala19.45
Appendix20.45
AtrioventricularNode15.8
BDCA4+_DentriticCells23.05
Bonemarrow15.7
BronchialEpithelialCells13.55
CD105+_Endothelial123.15
CD14+_Monocytes18.7
CD19+_BCells(neg._sel.)15.3
CD33+_Myeloid38.9
CD34+72.8
CD4+_Tcells17.35
CD56+_NKCells52.55
CD71+_EarlyErythroid14.55
CD8+_Tcells32.35
CardiacMyocytes27.2
Caudatenucleus12.1
Cerebellum10.8
CerebellumPeduncles17.55
CiliaryGanglion20.05
CingulateCortex14.1
Colorectaladenocarcinoma285.5
DorsalRootGanglion14.7
FetalThyroid13.6
Fetalbrain20.45
Fetalliver11.65
Fetallung9
GlobusPallidus11.6
Heart25.2
Hypothalamus13.15
Kidney12.9
Leukemia_chronicMyelogenousK-56235
Leukemia_promyelocytic-HL-6012.1
Leukemialymphoblastic(MOLT-4)10.9
Liver21.9
Lung13.1
Lymphnode9.3
Lymphoma_burkitts(Daudi)17.5
Lymphoma_burkitts(Raji)22.65
MedullaOblongata11
OccipitalLobe11.5
OlfactoryBulb9.85
Ovary11.3
Pancreas61.85
PancreaticIslet15
ParietalLobe16.15
Pituitary15.9
Placenta11.3
Pons13.2
PrefrontalCortex16.1
Prostate16.65
Salivarygland14.5
SkeletalMuscle23.25
Skin16.75
SmoothMuscle15.45
Spinalcord13.2
SubthalamicNucleus13.55
SuperiorCervicalGanglion23.15
TemporalLobe12.75
Testis10.95
TestisGermCell10.55
TestisIntersitial13.8
TestisLeydigCell15.25
TestisSeminiferousTubule11.15
Thalamus14.05
Thymus8.55
Thyroid15
Tongue17.05
Tonsil12.9
Trachea9.45
TrigeminalGanglion18.75
Uterus18.25
UterusCorpus14.3
WholeBlood13.45
Wholebrain10.4
colon62.25
pineal_day47.42
pineal_night25.58
retina16.075
small_intestine24.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12054_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.75 ± 0.48
Basal Forebrain7.01 ± 0.25
Basal Part of Pons6.4 ± 0.29
Cerebellar Cortex7.08 ± 0.3
Cerebellar Nuclei6.31 ± 0.27
Claustrum6.6 ± 0.65
Epithalamus6.26 ± 0.47
Frontal Lobe6.54 ± 0.43
Globus Pallidus7.48 ± 0.52
Hypothalamus6.44 ± 0.61
Insula6.47 ± 0.5
Limbic Lobe6.7 ± 0.37
Mesencephalon6.84 ± 0.46
Myelencephalon6.69 ± 0.5
Occipital Lobe6.72 ± 0.37
Parietal Lobe6.79 ± 0.46
Pontine Tegmentum6.73 ± 0.5
Striatum6.9 ± 0.66
Subthalamus6.14 ± 0.97
Temporal Lobe6.54 ± 0.35
Thalamus6.86 ± 0.38
White Matter7.07 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cdk8CBCerebellum3.66
3.83
Cdk8CTXCerebral cortex10.28
7.12
Cdk8HIPHippocampal region9.96
9.36
Cdk8HPFHippocampal formation9.32
8.07
Cdk8HYHypothalamus1.48
1.08
Cdk8LSXLateral septal complex2.82
1.76
Cdk8MBMidbrain2.38
2.13
Cdk8MYMedulla4.74
4.81
Cdk8OLFOlfactory bulb9.23
6.5
Cdk8PPons2.4
2.33
Cdk8PALPallidum4.12
3.35
Cdk8RHPRetrohippocampal region8.67
6.54
Cdk8sAMYStriatum-like amygdalar nuclei8.13
4.92
Cdk8STRStriatum5.81
3.89
Cdk8STRdStriatum dorsal region6.47
4.55
Cdk8STRvStriatum ventral region3.8
2.34
Cdk8THThalamus4.62
3.67
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CDK8_HUMAN_151 16 151 166 DLKPANILVMGEGPER PRIDE
PAp00010005 13 14 26 ERVEDLFEYEGCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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