AutismKB 2.0

Annotation Detail for KCNMB2


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Basic Information Top
Gene Symbol:KCNMB2 ( MGC22431 )
Gene Full Name: potassium large conductance calcium-activated channel, subfamily M, beta member 2
Band: 3q26.32
Quick LinksEntrez ID:10242; OMIM: 605214; Uniprot ID:KCMB2_HUMAN; ENSEMBL ID: ENSG00000197584; HGNC ID: 6286
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult11 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal42 / 336030712
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain15 / 110098913
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney6 / 21177728
larynx0 / 241450 
liver1 / 2077434
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221097_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.65
Adipocyte5.6
AdrenalCortex6.5
Adrenalgland5.1
Amygdala5.95
Appendix7.25
AtrioventricularNode8.8
BDCA4+_DentriticCells5.8
Bonemarrow7.75
BronchialEpithelialCells5.45
CD105+_Endothelial7
CD14+_Monocytes6.05
CD19+_BCells(neg._sel.)5.9
CD33+_Myeloid7.2
CD34+7
CD4+_Tcells5.9
CD56+_NKCells6.65
CD71+_EarlyErythroid5.4
CD8+_Tcells5.25
CardiacMyocytes7.35
Caudatenucleus5.3
Cerebellum5.25
CerebellumPeduncles6.65
CiliaryGanglion4.7
CingulateCortex6.25
Colorectaladenocarcinoma5.7
DorsalRootGanglion8.3
FetalThyroid5.5
Fetalbrain5.5
Fetalliver5.5
Fetallung4.55
GlobusPallidus5.45
Heart7.35
Hypothalamus6
Kidney5.6
Leukemia_chronicMyelogenousK-5625.15
Leukemia_promyelocytic-HL-604.9
Leukemialymphoblastic(MOLT-4)4.55
Liver7.9
Lung6.2
Lymphnode4.9
Lymphoma_burkitts(Daudi)7.45
Lymphoma_burkitts(Raji)8.05
MedullaOblongata5.2
OccipitalLobe6.2
OlfactoryBulb4.85
Ovary4.2
Pancreas4.6
PancreaticIslet11.45
ParietalLobe6.95
Pituitary7.6
Placenta5.7
Pons6.25
PrefrontalCortex6.95
Prostate6.55
Salivarygland4.7
SkeletalMuscle7.45
Skin5.3
SmoothMuscle6.25
Spinalcord6.2
SubthalamicNucleus5.3
SuperiorCervicalGanglion8.35
TemporalLobe5.4
Testis4.95
TestisGermCell4.65
TestisIntersitial4.8
TestisLeydigCell5.9
TestisSeminiferousTubule5
Thalamus5.9
Thymus4.6
Thyroid7
Tongue5.8
Tonsil5.9
Trachea4.85
TrigeminalGanglion8.05
Uterus4.5
UterusCorpus5.4
WholeBlood6
Wholebrain4.85
colon5.65
pineal_day7.04
pineal_night6.88
retina6.925
small_intestine5.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P170072
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.71 ± 0.85
Basal Forebrain3.74 ± 0.41
Basal Part of Pons4.9 ± 0.66
Cerebellar Cortex4.29 ± 0.67
Cerebellar Nuclei4.42 ± 0.69
Claustrum5.33 ± 0.51
Epithalamus4.91 ± 0.46
Frontal Lobe5.12 ± 0.44
Globus Pallidus4.17 ± 0.84
Hypothalamus4.02 ± 0.69
Insula5.28 ± 0.41
Limbic Lobe5.26 ± 0.67
Mesencephalon4.43 ± 0.59
Myelencephalon4.64 ± 0.76
Occipital Lobe4 ± 0.87
Parietal Lobe4.79 ± 0.58
Pontine Tegmentum4.57 ± 0.69
Striatum3.46 ± 1.07
Subthalamus7 ± 0.24
Temporal Lobe4.87 ± 0.5
Thalamus4.45 ± 0.67
White Matter3.1 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kcnmb2CBCerebellum2
2.99
Kcnmb2CTXCerebral cortex2.04
2.15
Kcnmb2HIPHippocampal region2.36
2.65
Kcnmb2HPFHippocampal formation2.14
2.76
Kcnmb2HYHypothalamus0.18
0.16
Kcnmb2LSXLateral septal complex0.41
0.46
Kcnmb2MBMidbrain1.19
1.58
Kcnmb2MYMedulla3.77
5
Kcnmb2OLFOlfactory bulb1.23
1.17
Kcnmb2PPons2.53
2.78
Kcnmb2PALPallidum1.14
0.96
Kcnmb2RHPRetrohippocampal region1.71
2.78
Kcnmb2sAMYStriatum-like amygdalar nuclei0.87
0.85
Kcnmb2STRStriatum0.78
0.68
Kcnmb2STRdStriatum dorsal region0.83
0.75
Kcnmb2STRvStriatum ventral region0.8
0.56
Kcnmb2THThalamus1.9
1.95
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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